 Autophagy-Related Protein 12
"Autophagy-Related Protein 12" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A UBIQUITIN-like modifier protein that functions in AUTOPHAGOSOME formation, CYTOPLASM to VACUOLE transport, MITOPHAGY, and nucleophagy. Conjugation with ATG5 PROTEIN or ATG10 is essential for its function. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme for lipid modification of ATG8 FAMILY PROTEINS and their localization to vesicle membranes.
| Descriptor ID |
D000071192
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| MeSH Number(s) |
D12.776.094.391 D12.776.947.125
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| Concept/Terms |
Autophagy-Related Protein 12- Autophagy-Related Protein 12
- Autophagy Related Protein 12
- ATG12 Protein
- Ubiquitin-Like Protein ATG12
- ATG12, Ubiquitin-Like Protein
- Ubiquitin Like Protein ATG12
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Below are MeSH descriptors whose meaning is more general than "Autophagy-Related Protein 12".
Below are MeSH descriptors whose meaning is more specific than "Autophagy-Related Protein 12".
This graph shows the total number of publications written about "Autophagy-Related Protein 12" by people in this website by year, and whether "Autophagy-Related Protein 12" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 | | 2012 | 0 | 2 | 2 | | 2015 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Autophagy-Related Protein 12" by people in Profiles.
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Atwood DJ, Brown CN, Holditch SJ, Pokhrel D, Thorburn A, Hopp K, Edelstein CL. The effect of trehalose on autophagy-related proteins and cyst growth in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease. Cell Signal. 2020 11; 75:109760.
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Bonet-Ponce L, Saez-Atienzar S, da Casa C, Flores-Bellver M, Barcia JM, Sancho-Pelluz J, Romero FJ, Jordan J, Galindo MF. On the mechanism underlying ethanol-induced mitochondrial dynamic disruption and autophagy response. Biochim Biophys Acta. 2015 Jul; 1852(7):1400-9.
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Macintosh RL, Timpson P, Thorburn J, Anderson KI, Thorburn A, Ryan KM. Inhibition of autophagy impairs tumor cell invasion in an organotypic model. Cell Cycle. 2012 May 15; 11(10):2022-9.
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Maycotte P, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Autophagy. 2012 Feb 01; 8(2):200-12.
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Levy JM, Thorburn A. Modulation of pediatric brain tumor autophagy and chemosensitivity. J Neurooncol. 2012 Jan; 106(2):281-90.
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