 Actin-Related Protein 2-3 Complex
"Actin-Related Protein 2-3 Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments.
| Descriptor ID |
D051376
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| MeSH Number(s) |
D05.750.078.730.246 D12.776.220.525.246
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| Concept/Terms |
Actin-Related Protein 2-3 Complex- Actin-Related Protein 2-3 Complex
- Actin Related Protein 2 3 Complex
- Arp2-3 Complex
- Arp2 3 Complex
- Arp2-3 Protein Complex
- Arp2 3 Protein Complex
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Below are MeSH descriptors whose meaning is more general than "Actin-Related Protein 2-3 Complex".
Below are MeSH descriptors whose meaning is more specific than "Actin-Related Protein 2-3 Complex".
This graph shows the total number of publications written about "Actin-Related Protein 2-3 Complex" by people in this website by year, and whether "Actin-Related Protein 2-3 Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2020 | 0 | 2 | 2 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Actin-Related Protein 2-3 Complex" by people in Profiles.
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Thompson SB, Waldman MM, Jacobelli J. Polymerization power: effectors of actin polymerization as?regulators of T lymphocyte migration through complex environments. FEBS J. 2022 10; 289(20):6154-6171.
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Walpole GFW, Plumb JD, Chung D, Tang B, Boulay B, Osborne DG, Piotrowski JT, Catz SD, Billadeau DD, Grinstein S, Jaumouill? V. Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation. Cell Rep. 2020 06 02; 31(9):107721.
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Musah AS, Brown TL, Jeffries MA, Shang Q, Hashimoto H, Evangelou AV, Kowalski A, Batish M, Macklin WB, Wood TL. Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination. J Neurosci. 2020 04 08; 40(15):2993-3007.
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Schaffer AE, Breuss MW, Caglayan AO, Al-Sanaa N, Al-Abdulwahed HY, Kaymak?alan H, Yilmaz C, Zaki MS, Rosti RO, Copeland B, Baek ST, Musaev D, Scott EC, Ben-Omran T, Kariminejad A, Kayserili H, Mojahedi F, Kara M, Cai N, Silhavy JL, Elsharif S, Fenercioglu E, Barshop BA, Kara B, Wang R, Stanley V, James KN, Nachnani R, Kalur A, Megahed H, Incecik F, Danda S, Alanay Y, Faqeih E, Melikishvili G, Mansour L, Miller I, Sukhudyan B, Chelly J, Dobyns WB, Bilguvar K, Jamra RA, Gunel M, Gleeson JG. Biallelic loss of human CTNNA2, encoding aN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migration. Nat Genet. 2018 08; 50(8):1093-1101.
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Thiam HR, Vargas P, Carpi N, Crespo CL, Raab M, Terriac E, King MC, Jacobelli J, Alberts AS, Stradal T, Lennon-Dumenil AM, Piel M. Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments. Nat Commun. 2016 Mar 15; 7:10997.
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Wegner AM, Nebhan CA, Hu L, Majumdar D, Meier KM, Weaver AM, Webb DJ. N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. J Biol Chem. 2008 Jun 06; 283(23):15912-20.
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Tomasevic N, Jia Z, Russell A, Fujii T, Hartman JJ, Clancy S, Wang M, Beraud C, Wood KW, Sakowicz R. Differential regulation of WASP and N-WASP by Cdc42, Rac1, Nck, and PI(4,5)P2. Biochemistry. 2007 Mar 20; 46(11):3494-502.
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Rothschild BL, Shim AH, Ammer AG, Kelley LC, Irby KB, Head JA, Chen L, Varella-Garcia M, Sacks PG, Frederick B, Raben D, Weed SA. Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification. Cancer Res. 2006 Aug 15; 66(16):8017-25.
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