Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

Jordan Jacobelli

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/724-5630

    Collapse Research 
    Collapse research activities and funding
    R21CA280145     (JACOBELLI, JORDAN)Apr 1, 2024 - Mar 31, 2026
    NIH
    Engineered T cells for improved migration into solid tumor sites
    Role: Principal Investigator
    R01AI167943     (JACOBELLI, JORDAN)Sep 23, 2022 - Jul 31, 2027
    NIH
    Mechanisms of regulation of lymphocyte migration by actin cytoskeletal effectors
    Role: Principal Investigator
    R01AI125553     (JACOBELLI, JORDAN)Dec 1, 2016 - Nov 30, 2021
    NIH
    Regulation of T Cell Extravasation and Activation by Ena/Vasp Proteins
    Role: Principal Investigator
    R56AI105111     (JACOBELLI, JORDAN)May 1, 2014 - Apr 30, 2016
    NIH
    Regulation of T Cell Extravasation and Trafficking by the Actin Cytoskeleton
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Waldman MM, Rahkola JT, Sigler AL, Chung JW, Willett BAS, Kedl RM, Friedman RS, Jacobelli J. Ena/VASP Protein-Mediated Actin Polymerization Contributes to Na?ve CD8+ T Cell Activation and Expansion by Promoting T Cell-APC Interactions In Vivo. Front Immunol. 2022; 13:856977. PMID: 35757762.
      View in: PubMed
    2. Kremer KN, Buser A, Thumkeo D, Narumiya S, Jacobelli J, Pelanda R, Torres RM. LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2118816119. PMID: 35394866.
      View in: PubMed
    3. Jacobelli J, Buser AE, Heiden DL, Friedman RS. Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging. Immunol Rev. 2022 03; 306(1):181-199. PMID: 34825390.
      View in: PubMed
    4. Lindsay RS, Whitesell JC, Dew KE, Rodriguez E, Sandor AM, Tracy D, Yannacone SF, Basta BN, Jacobelli J, Friedman RS. MERTK on mononuclear phagocytes regulates T cell antigen recognition at autoimmune and tumor sites. J Exp Med. 2021 10 04; 218(10). PMID: 34415994.
      View in: PubMed
    5. Thompson SB, Waldman MM, Jacobelli J. Polymerization power: effectors of actin polymerization as?regulators of T lymphocyte migration through complex environments. FEBS J. 2022 10; 289(20):6154-6171. PMID: 34273243.
      View in: PubMed
    6. Jha V, Nicholson LK, Gardner EM, Rahkola JT, Pratap H, Scott J, Borgeson M, Jacobelli J, Janoff EN. Impact of HIV-1 Infection and Antigen Class on T Follicular Helper Cell Responses to Pneumococcal Polysaccharide-Protein Conjugate Vaccine-13. J Immunol. 2021 05 15; 206(10):2402-2411. PMID: 33931485.
      View in: PubMed
    7. Thompson SB, Sandor AM, Lui V, Chung JW, Waldman MM, Long RA, Estin ML, Matsuda JL, Friedman RS, Jacobelli J. Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity. Elife. 2020 06 08; 9. PMID: 32510333.
      View in: PubMed
    8. Sandor AM, Jacobelli J, Friedman RS. Immune cell trafficking to the islets during type 1 diabetes. Clin Exp Immunol. 2019 12; 198(3):314-325. PMID: 31343073.
      View in: PubMed
    9. Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS. CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes. Front Immunol. 2019; 10:99. PMID: 30766536.
      View in: PubMed
    10. Thompson SB, Wigton EJ, Krovi SH, Chung JW, Long RA, Jacobelli J. The Formin mDia1 Regulates Acute Lymphoblastic Leukemia Engraftment, Migration, and Progression in vivo. Front Oncol. 2018; 8:389. PMID: 30294591.
      View in: PubMed
    11. Dell'Aringa M, Reinhardt RL, Friedman RS, Jacobelli J. Live Imaging of IL-4-Expressing T Follicular Helper Cells in Explanted Lymph Nodes. Methods Mol Biol. 2018; 1799:225-235. PMID: 29956155.
      View in: PubMed
    12. Estin ML, Thompson SB, Traxinger B, Fisher MH, Friedman RS, Jacobelli J. Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2901-E2910. PMID: 28320969.
      View in: PubMed
    13. Desch AN, Gibbings SL, Goyal R, Kolde R, Bednarek J, Bruno T, Slansky JE, Jacobelli J, Mason R, Ito Y, Messier E, Randolph GJ, Prabagar M, Atif SM, Segura E, Xavier RJ, Bratton DL, Janssen WJ, Henson PM, Jakubzick CV. Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes. Am J Respir Crit Care Med. 2016 Mar 15; 193(6):614-26. PMID: 26551758.
      View in: PubMed
    14. Thiam HR, Vargas P, Carpi N, Crespo CL, Raab M, Terriac E, King MC, Jacobelli J, Alberts AS, Stradal T, Lennon-Dumenil AM, Piel M. Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments. Nat Commun. 2016 Mar 15; 7:10997. PMID: 26975831.
      View in: PubMed
    15. Wigton EJ, Thompson SB, Long RA, Jacobelli J. Myosin-IIA regulates leukemia engraftment and brain infiltration in a mouse model of acute lymphoblastic leukemia. J Leukoc Biol. 2016 07; 100(1):143-53. PMID: 26792819.
      View in: PubMed
    16. Chabaud M, Heuz? ML, Bretou M, Vargas P, Maiuri P, Solanes P, Maurin M, Terriac E, Le Berre M, Lankar D, Piolot T, Adelstein RS, Zhang Y, Sixt M, Jacobelli J, B?nichou O, Voituriez R, Piel M, Lennon-Dum?nil AM. Corrigendum: Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells. Nat Commun. 2015 Aug 14; 6:8122. PMID: 26271903.
      View in: PubMed
    17. Chabaud M, Heuz? ML, Bretou M, Vargas P, Maiuri P, Solanes P, Maurin M, Terriac E, Le Berre M, Lankar D, Piolot T, Adelstein RS, Zhang Y, Sixt M, Jacobelli J, B?nichou O, Voituriez R, Piel M, Lennon-Dum?nil AM. Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells. Nat Commun. 2015 Jun 25; 6:7526. PMID: 26109323.
      View in: PubMed
    18. Rubtsov AV, Rubtsova K, Kappler JW, Jacobelli J, Friedman RS, Marrack P. CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs. J Immunol. 2015 Jul 01; 195(1):71-9. PMID: 26034175.
      View in: PubMed
    19. Lindsay RS, Corbin K, Mahne A, Levitt BE, Gebert MJ, Wigton EJ, Bradley BJ, Haskins K, Jacobelli J, Tang Q, Krummel MF, Friedman RS. Antigen recognition in the islets changes with progression of autoimmune islet infiltration. J Immunol. 2015 Jan 15; 194(2):522-30. PMID: 25505281.
      View in: PubMed
    20. Friedman RS, Lindsay RS, Lilly JK, Nguyen V, Sorensen CM, Jacobelli J, Krummel MF. An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9223-8. PMID: 24927530.
      View in: PubMed
    21. Krummel MF, Friedman RS, Jacobelli J. Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA. Curr Opin Cell Biol. 2014 Oct; 30:9-16. PMID: 24905977.
      View in: PubMed
    22. Jacobelli J, Estin Matthews M, Chen S, Krummel MF. Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers. PLoS One. 2013; 8(9):e75151. PMID: 24069389.
      View in: PubMed
    23. Jacobelli J, Lindsay RS, Friedman RS. Peripheral tolerance and autoimmunity: lessons from in vivo imaging. Immunol Res. 2013 Mar; 55(1-3):146-54. PMID: 22956468.
      View in: PubMed
    24. McKee AS, Burchill MA, Munks MW, Jin L, Kappler JW, Friedman RS, Jacobelli J, Marrack P. Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):E1122-31. PMID: 23447566.
      View in: PubMed
    25. G?rard A, Beemiller P, Friedman RS, Jacobelli J, Krummel MF. Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses. Immunol Rev. 2013 Jan; 251(1):80-96. PMID: 23278742.
      View in: PubMed
    26. Huang Y, Aydintug MK, Loomis J, Macleod MK, McKee AS, Kirchenbaum G, Jakubzick CV, Kedl RM, Sun D, Jacobelli J, O'Brien RL, Born WK. Antigen-specific regulation of IgE antibodies by non-antigen-specific ?d T cells. J Immunol. 2013 Feb 01; 190(3):913-21. PMID: 23275606.
      View in: PubMed
    27. Beemiller P, Jacobelli J, Krummel MF. Integration of the movement of signaling microclusters with cellular motility in immunological synapses. Nat Immunol. 2012 Jul 01; 13(8):787-95. PMID: 22751140.
      View in: PubMed
    28. Friedman RS, Beemiller P, Sorensen CM, Jacobelli J, Krummel MF. Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. J Exp Med. 2010 Nov 22; 207(12):2733-49. PMID: 21041455.
      View in: PubMed
    29. Jacobelli J, Friedman RS, Conti MA, Lennon-Dumenil AM, Piel M, Sorensen CM, Adelstein RS, Krummel MF. Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol. 2010 Oct; 11(10):953-61. PMID: 20835229.
      View in: PubMed
    30. Jacobelli J, Bennett FC, Pandurangi P, Tooley AJ, Krummel MF. Myosin-IIA and ICAM-1 regulate the interchange between two distinct modes of T cell migration. J Immunol. 2009 Feb 15; 182(4):2041-50. PMID: 19201857.
      View in: PubMed
    31. Tooley AJ, Gilden J, Jacobelli J, Beemiller P, Trimble WS, Kinoshita M, Krummel MF. Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol. 2009 Jan; 11(1):17-26. PMID: 19043408.
      View in: PubMed
    32. Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May; 15(5):535-43. PMID: 17502099.
      View in: PubMed
    33. Friedman RS, Jacobelli J, Krummel MF. Surface-bound chemokines capture and prime T cells for synapse formation. Nat Immunol. 2006 Oct; 7(10):1101-8. PMID: 16964261.
      View in: PubMed
    34. Friedman RS, Jacobelli J, Krummel MF. Mechanisms of T cell motility and arrest: deciphering the relationship between intra- and extracellular determinants. Semin Immunol. 2005 Dec; 17(6):387-99. PMID: 16219473.
      View in: PubMed
    35. Tooley AJ, Jacobelli J, Moldovan MC, Douglas A, Krummel MF. T cell synapse assembly: proteins, motors and the underlying cell biology. Semin Immunol. 2005 Feb; 17(1):65-75. PMID: 15582489.
      View in: PubMed
    36. Jacobelli J, Andres PG, Boisvert J, Krummel MF. New views of the immunological synapse: variations in assembly and function. Curr Opin Immunol. 2004 Jun; 16(3):345-52. PMID: 15134784.
      View in: PubMed
    37. Jacobelli J, Chmura SA, Buxton DB, Davis MM, Krummel MF. A single class II myosin modulates T cell motility and stopping, but not synapse formation. Nat Immunol. 2004 May; 5(5):531-8. PMID: 15064761.
      View in: PubMed
    38. Gismondi A, Cifaldi L, Mazza C, Giliani S, Parolini S, Morrone S, Jacobelli J, Bandiera E, Notarangelo L, Santoni A. Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect. Blood. 2004 Jul 15; 104(2):436-43. PMID: 15001467.
      View in: PubMed
    39. Gismondi A, Jacobelli J, Strippoli R, Mainiero F, Soriani A, Cifaldi L, Piccoli M, Frati L, Santoni A. Proline-rich tyrosine kinase 2 and Rac activation by chemokine and integrin receptors controls NK cell transendothelial migration. J Immunol. 2003 Mar 15; 170(6):3065-73. PMID: 12626562.
      View in: PubMed
    40. Gismondi A, Jacobelli J, Mainiero F, Paolini R, Piccoli M, Frati L, Santoni A. Cutting edge: functional role for proline-rich tyrosine kinase 2 in NK cell-mediated natural cytotoxicity. J Immunol. 2000 Mar 01; 164(5):2272-6. PMID: 10679059.
      View in: PubMed
    41. Mainiero F, Soriani A, Strippoli R, Jacobelli J, Gismondi A, Piccoli M, Frati L, Santoni A. RAC1/P38 MAPK signaling pathway controls beta1 integrin-induced interleukin-8 production in human natural killer cells. Immunity. 2000 Jan; 12(1):7-16. PMID: 10661401.
      View in: PubMed
    42. Milella M, Jacobelli J, Cavallo F, Guarini A, Velotti F, Frati L, Fo? R, Forni G, Santoni A. Interleukin-2 gene transfer into human transitional cell carcinoma of the urinary bladder. Br J Cancer. 1999 Feb; 79(5-6):770-9. PMID: 10070868.
      View in: PubMed
    43. Mainiero F, Gismondi A, Soriani A, Cippitelli M, Palmieri G, Jacobelli J, Piccoli M, Frati L, Santoni A. Integrin-mediated ras-extracellular regulated kinase (ERK) signaling regulates interferon gamma production in human natural killer cells. J Exp Med. 1998 Oct 05; 188(7):1267-75. PMID: 9763606.
      View in: PubMed
    Jacobelli's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (245) concept(s)
    _
    Co-Authors Expand Description
    See all (22) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2024 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)