 S-Phase Kinase-Associated Proteins
"S-Phase Kinase-Associated Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of structurally-related proteins that were originally identified by their ability to complex with cyclin proteins (CYCLINS). They share a common domain that binds specifically to F-BOX MOTIFS. They take part in SKP CULLIN F-BOX PROTEIN LIGASES, where they can bind to a variety of F-BOX PROTEINS.
| Descriptor ID |
D044786
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| MeSH Number(s) |
D12.776.157.743
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| Concept/Terms |
S-Phase Kinase-Associated Proteins- S-Phase Kinase-Associated Proteins
- Kinase-Associated Proteins, S-Phase
- Proteins, S-Phase Kinase-Associated
- S Phase Kinase Associated Proteins
- Skp Domain Protein
- S-Phase Kinase Associated Protein
- S Phase Kinase Associated Protein
- Skp Domain Proteins
Skp2 Proteins- Skp2 Proteins
- p45(SKP2) Protein
- p45(SKP2)
- Skp2 Protein
- p45 SKP2
- SKP2, p45
- SCF(SKP2)
Skp1 Proteins- Skp1 Proteins
- p19(SKP1) Protein
- Skp1 Protein
- p19 SKP1
- SKP1, p19
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Below are MeSH descriptors whose meaning is more general than "S-Phase Kinase-Associated Proteins".
Below are MeSH descriptors whose meaning is more specific than "S-Phase Kinase-Associated Proteins".
This graph shows the total number of publications written about "S-Phase Kinase-Associated Proteins" by people in this website by year, and whether "S-Phase Kinase-Associated Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2003 | 0 | 1 | 1 | | 2004 | 2 | 0 | 2 | | 2005 | 2 | 0 | 2 | | 2007 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 2 | 2 | | 2013 | 1 | 2 | 3 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "S-Phase Kinase-Associated Proteins" by people in Profiles.
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Sheikh MO, Thieker D, Chalmers G, Schafer CM, Ishihara M, Azadi P, Woods RJ, Glushka JN, Bendiak B, Prestegard JH, West CM. O2 sensing-associated glycosylation exposes the F-box-combining site of the Dictyostelium Skp1 subunit in E3 ubiquitin ligases. J Biol Chem. 2017 11 17; 292(46):18897-18915.
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Bikkavilli RK, Avasarala S, Van Scoyk M, Arcaroli J, Brzezinski C, Zhang W, Edwards MG, Rathinam MK, Zhou T, Tauler J, Borowicz S, Lussier YA, Parr BA, Cool CD, Winn RA. Wnt7a is a novel inducer of ?-catenin-independent tumor-suppressive cellular senescence in lung cancer. Oncogene. 2015 Oct 16; 34(42):5317-28.
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Overton KW, Spencer SL, Noderer WL, Meyer T, Wang CL. Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):E4386-93.
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Bargagna-Mohan P, Deokule SP, Thompson K, Wizeman J, Srinivasan C, Vooturi S, Kompella UB, Mohan R. Withaferin A effectively targets soluble vimentin in the glaucoma filtration surgical model of fibrosis. PLoS One. 2013; 8(5):e63881.
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Jackson SJ, Zhang Z, Feng D, Flagg M, O'Loughlin E, Wang D, Stokes N, Fuchs E, Yi R. Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation. Development. 2013 May; 140(9):1882-91.
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Ungermannova D, Lee J, Zhang G, Dallmann HG, McHenry CS, Liu X. High-throughput screening AlphaScreen assay for identification of small-molecule inhibitors of ubiquitin E3 ligase SCFSkp2-Cks1. J Biomol Screen. 2013 Sep; 18(8):910-20.
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Zhang Q, Spears E, Boone DN, Li Z, Gregory MA, Hann SR. Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):978-83.
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Sikka A, Kaur M, Agarwal C, Deep G, Agarwal R. Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation. Cell Cycle. 2012 Apr 01; 11(7):1374-82.
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Van Rechem C, Black JC, Abbas T, Allen A, Rinehart CA, Yuan GC, Dutta A, Whetstine JR. The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. J Biol Chem. 2011 Sep 02; 286(35):30462-30470.
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Cen B, Mahajan S, Zemskova M, Beharry Z, Lin YW, Cramer SD, Lilly MB, Kraft AS. Regulation of Skp2 levels by the Pim-1 protein kinase. J Biol Chem. 2010 Sep 17; 285(38):29128-37.
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