 Immune Tolerance
"Immune Tolerance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
| Descriptor ID |
D007108
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| MeSH Number(s) |
G12.535.425
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Immune Tolerance".
Below are MeSH descriptors whose meaning is more specific than "Immune Tolerance".
This graph shows the total number of publications written about "Immune Tolerance" by people in this website by year, and whether "Immune Tolerance" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 1 | 3 | | 1997 | 2 | 4 | 6 | | 1998 | 1 | 2 | 3 | | 1999 | 0 | 3 | 3 | | 2000 | 2 | 3 | 5 | | 2001 | 3 | 1 | 4 | | 2002 | 3 | 1 | 4 | | 2003 | 1 | 3 | 4 | | 2004 | 4 | 3 | 7 | | 2005 | 2 | 3 | 5 | | 2006 | 5 | 3 | 8 | | 2007 | 3 | 1 | 4 | | 2008 | 9 | 2 | 11 | | 2009 | 4 | 4 | 8 | | 2010 | 4 | 5 | 9 | | 2011 | 5 | 5 | 10 | | 2012 | 7 | 7 | 14 | | 2013 | 3 | 3 | 6 | | 2014 | 5 | 5 | 10 | | 2015 | 4 | 4 | 8 | | 2016 | 1 | 6 | 7 | | 2017 | 5 | 8 | 13 | | 2018 | 5 | 6 | 11 | | 2019 | 3 | 7 | 10 | | 2020 | 1 | 3 | 4 | | 2021 | 3 | 6 | 9 | | 2022 | 1 | 3 | 4 | | 2023 | 0 | 3 | 3 | | 2024 | 1 | 3 | 4 | | 2025 | 3 | 2 | 5 | | 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immune Tolerance" by people in Profiles.
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Greenbaum CJ, Long SA, Gitelman SE, Gaglia JL, Daniels M, Brusko TM, Lord S, Bundy BN, Krischer JP, Haller MJ, Steck AK, DiMeglio LA, Evans-Molina C, Moran A, Prahalad P, Wilson DM, Russell WE, Sherr JL, Raskin P, Clements MA, Moore WV, Libman I, Wassermann K, von Herrath M, Bergholdt R, Hastrup H, Kobernat SE, Kus AM, Tung LW, Goland RS, Herold KC. Phase I Clinical Trial of Islet Antigen-Specific Plasmid Coexpressing Tolerogenic Proteins Demonstrates Safety in Adults With Type 1 Diabetes. Diabetes. 2026 Mar 01; 75(3):506-518.
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Nachod BE, Thatte AS, Palanki R, Mitchell MJ. Nanoparticle-Based Tolerogenic Vaccines: Next-Generation Strategies for Autoimmune and Allergic Disease Therapies. Angew Chem Int Ed Engl. 2026 Feb 02; 65(6):e24097.
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Bernstein J, Keller L, Pacheco K. Updates in Metal Allergy: A Review of New Pathways of Sensitization, Exposure, and Treatment. Curr Allergy Asthma Rep. 2025 Jun 19; 25(1):28.
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Elder AM, Fairchild HR, Kines KT, Cozzens LM, Becks AR, Slansky JE, Anderson SM, Lyons TR. Semaphorin7A and PD-L1 cooperatively drive immunosuppression during mammary involution and breast cancer. Cell Rep. 2025 May 27; 44(5):115676.
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Jha V, Freed BM, Sunderhaus ER, Lee JE, Prage EB, Miglani M, Rosloniec EF, Matsuda JL, Coulombe MG, McKee AS, Roark CL. Substitution of Glutamic Acid at Position 71 of DRß1*04:01 and Collagen-Specific Tolerance Without Alloreactivity. Arthritis Rheumatol. 2025 May; 77(5):526-535.
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Kremer KN, Khammash HA, Miranda AM, Rutt LN, Twardy SM, Anton PE, Campbell ML, Garza-Ortiz C, Orlicky DJ, Pelanda R, McCullough RL, Torres RM. Liver sinusoidal endothelial cells regulate the balance between hepatic immunosuppression and immunosurveillance. Front Immunol. 2024; 15:1497788.
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Blades CM, Huang CA, Mathes DW. The current state of tolerance induction in vascularized composite allotransplantation. Curr Opin Organ Transplant. 2024 Dec 01; 29(6):368-375.
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Anagnostou A, Mack DP, Johannes S, Shaker M, Abrams EM, DeSanto K, Greenhawt M. The Safety and Efficacy of Baked Egg and Milk Dietary Advancement Therapy: A Systematic Review and Meta-Analysis. J Allergy Clin Immunol Pract. 2024 Sep; 12(9):2468-2480.
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McCaleb MR, Miranda AM, Khammash HA, Torres RM, Pelanda R. Regulation of Foxo1 expression is critical for central B cell tolerance and allelic exclusion. Cell Rep. 2024 06 25; 43(6):114283.
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Smith JA, Yuen BTK, Purtha W, Balolong JM, Phipps JD, Crawford F, Bluestone JA, Kappler JW, Anderson MS. Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones. Proc Natl Acad Sci U S A. 2024 May 14; 121(20):e2320268121.
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