 Clonal Anergy
"Clonal Anergy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Functional inactivation of T- or B-lymphocytes rendering them incapable of eliciting an immune response to antigen. This occurs through different mechanisms in the two kinds of lymphocytes and can contribute to SELF TOLERANCE.
| Descriptor ID |
D017635
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| MeSH Number(s) |
G12.535.425.100
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| Concept/Terms |
Clonal Anergy- Clonal Anergy
- Anergies, Clonal
- Anergy, Clonal
- Clonal Anergies
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Below are MeSH descriptors whose meaning is more general than "Clonal Anergy".
Below are MeSH descriptors whose meaning is more specific than "Clonal Anergy".
This graph shows the total number of publications written about "Clonal Anergy" by people in this website by year, and whether "Clonal Anergy" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 1999 | 2 | 0 | 2 | | 2000 | 0 | 2 | 2 | | 2001 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 2005 | 2 | 1 | 3 | | 2006 | 2 | 0 | 2 | | 2007 | 2 | 0 | 2 | | 2009 | 1 | 1 | 2 | | 2010 | 2 | 1 | 3 | | 2011 | 1 | 1 | 2 | | 2012 | 2 | 2 | 4 | | 2013 | 1 | 0 | 1 | | 2014 | 2 | 0 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Clonal Anergy" by people in Profiles.
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Wemlinger SM, Parker Harp CR, Yu B, Hardy IR, Seefeldt M, Matsuda J, Mingueneau M, Spilker KA, Cameron TO, Larrick JW, Getahun A, Cambier JC. Preclinical Analysis of Candidate Anti-Human CD79 Therapeutic Antibodies Using a Humanized CD79 Mouse Model. J Immunol. 2022 04 01; 208(7):1566-1584.
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Chen Z, Krinsky A, Woolaver RA, Wang X, Chen SMY, Popolizio V, Xie P, Wang JH. TRAF3 Acts as a Checkpoint of B Cell Receptor Signaling to Control Antibody Class Switch Recombination and Anergy. J Immunol. 2020 08 01; 205(3):830-841.
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Franks SE, Cambier JC. Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy. Front Immunol. 2018; 9:665.
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Smith MJ, Rihanek M, Wasserfall C, Mathews CE, Atkinson MA, Gottlieb PA, Cambier JC. Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles. Diabetes. 2018 04; 67(4):697-703.
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Smith MJ, Rihanek M, Coleman BM, Gottlieb PA, Sarapura VD, Cambier JC. Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients. J Autoimmun. 2018 05; 89:82-89.
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Getahun A, Beavers NA, Larson SR, Shlomchik MJ, Cambier JC. Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells. J Exp Med. 2016 05 02; 213(5):751-69.
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Akerlund J, Getahun A, Cambier JC. B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens. J Autoimmun. 2015 Aug; 62:45-54.
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Smith MJ, Packard TA, O'Neill SK, Henry Dunand CJ, Huang M, Fitzgerald-Miller L, Stowell D, Hinman RM, Wilson PC, Gottlieb PA, Cambier JC. Loss of anergic B cells in prediabetic and new-onset type 1 diabetic patients. Diabetes. 2015 May; 64(5):1703-12.
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Hardy IR, Anceriz N, Rousseau F, Seefeldt MB, Hatterer E, Irla M, Buatois V, Chatel LE, Getahun A, Fletcher A, Cons L, Pontini G, Hertzberg NA, Magistrelli G, Malinge P, Smith MJ, Reith W, Kosco-Vilbois MH, Ferlin WG, Cambier JC. Anti-CD79 antibody induces B cell anergy that protects against autoimmunity. J Immunol. 2014 Feb 15; 192(4):1641-50.
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Kendall PL, Case JB, Sullivan AM, Holderness JS, Wells KS, Liu E, Thomas JW. Tolerant anti-insulin B cells are effective APCs. J Immunol. 2013 Mar 15; 190(6):2519-26.
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