Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Roberta Pelanda

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/724-8666

    Collapse Research 
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    R01AI181854     (PELANDA, ROBERTA)May 10, 2024 - Mar 31, 2029
    NIH
    Contribution and interplay of CXCR4 and integrins in central B cell tolerance
    Role: Principal Investigator

    R21AI156232     (PELANDA, ROBERTA)Jan 28, 2021 - Jun 30, 2023
    NIH
    Contribution of c-Maf to regulatory B cells and antibody-secreting cells
    Role: Principal Investigator

    R01AI152535     (PELANDA, ROBERTA)Feb 25, 2020 - Jan 31, 2025
    NIH
    Role and mechanisms of the PI3K pathway in B cell tolerance
    Role: Principal Investigator

    R21AI131639     (PELANDA, ROBERTA)Feb 10, 2017 - Jan 31, 2020
    NIH
    Testing an alternative model of central B cell tolerance
    Role: Principal Investigator

    R01AI124474     (PELANDA, ROBERTA)Feb 5, 2016 - Jan 31, 2021
    NIH
    Studies of human B cell tolerance, from a humanized mouse model to human beings
    Role: Principal Investigator

    R21AI122670     (PELANDA, ROBERTA)Jan 1, 2016 - Jun 30, 2018
    NIH
    Developing a new model for EBV-mediated T cell diseases
    Role: Principal Investigator

    R21AI105523     (PELANDA, ROBERTA)Jan 15, 2013 - Dec 31, 2015
    NIH
    Human B Cell Development and Function in Humanized Mice Expressing Human BAFF
    Role: Principal Investigator

    R21AI073629     (PELANDA, ROBERTA)Jun 5, 2008 - May 31, 2010
    NIH
    Analysis of Human B Cell Tolerance in Humanized Mice
    Role: Principal Investigator

    T32AI074491     (PELANDA, ROBERTA)Jul 1, 2007 - Jun 30, 2025
    NIH
    Molecular Mechanisms of Immune Tolerance
    Role: Principal Investigator

    R21AI063321     (PELANDA, ROBERTA)Jul 1, 2005 - Jun 30, 2008
    NIH
    Modulatory signaling motifs in B cell antigen receptor function
    Role: Principal Investigator

    R56AI052310     (PELANDA, ROBERTA)Jul 1, 2003 - Mar 31, 2008
    NIH
    Tolerance in Polyclonal and Oligoclonal Immune Systems
    Role: Principal Investigator

    R01AI052310     (PELANDA, ROBERTA)Jul 1, 2002 - Nov 30, 2018
    NIH
    Tolerance in polyclonal and oligoclonal immune systems
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Castleman MJ, Santos AL, Lesteberg KE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Activation and pro-inflammatory cytokine production by unswitched memory B cells during SARS-CoV-2 infection. Front Immunol. 2023; 14:1213344. PMID: 37638016.
      View in: PubMed
    2. Turner JA, Fredrickson MA, D'Antonio M, Katsnelson E, MacBeth M, Van Gulick R, Chimed TS, McCarter M, D'Alessandro A, Robinson WA, Couts KL, Pelanda R, Klarquist J, Tobin RP, Torres RM. Lysophosphatidic acid modulates CD8 T cell immunosurveillance and metabolism to impair anti-tumor immunity. Nat Commun. 2023 06 03; 14(1):3214. PMID: 37270644.
      View in: PubMed
    3. Torres RM, Turner JA, D'Antonio M, Pelanda R, Kremer KN. Regulation of CD8 T-cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid. Immunol Rev. 2023 08; 317(1):203-222. PMID: 37096808.
      View in: PubMed
    4. McCaleb MR, Miranda AM, Ratliff KC, Torres RM, Pelanda R. CD19 Is Internalized Together with IgM in Proportion to B Cell Receptor Stimulation and Is Modulated by Phosphatidylinositol 3-Kinase in Bone Marrow Immature B Cells. Immunohorizons. 2023 01 01; 7(1):49-63. PMID: 36637517.
      View in: PubMed
    5. Lanis JM, Lewis MS, Strassburger H, Larsen K, Bagby SM, Dominguez ATA, Mar?n-Jim?nez JA, Pelanda R, Pitts TM, Lang J. Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors. J Vis Exp. 2022 12 16; (190). PMID: 36591990.
      View in: PubMed
    6. Lang J, Leal AD, Mar?n-Jim?nez JA, Hartman SJ, Shulman J, Navarro NM, Lewis MS, Capasso A, Bagby SM, Yacob BW, MacBeth M, Freed BM, Eckhardt SG, Jordan K, Blatchford PJ, Pelanda R, Lieu CH, Messersmith WA, Pitts TM. Cabozantinib sensitizes microsatellite stable colorectal cancer to immune checkpoint blockade by immune modulation in human immune system mouse models. Front Oncol. 2022; 12:877635. PMID: 36419897.
      View in: PubMed
    7. Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells. Front Immunol. 2022; 13:988125. PMID: 36131937.
      View in: PubMed
    8. Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. SARS-CoV-2 infection relaxes peripheral B cell tolerance. J Exp Med. 2022 06 06; 219(6). PMID: 35420627.
      View in: PubMed
    9. Kremer KN, Buser A, Thumkeo D, Narumiya S, Jacobelli J, Pelanda R, Torres RM. LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2118816119. PMID: 35394866.
      View in: PubMed
    10. Pelanda R, Zikherman J. Many Achilles' heels of B and T cell tolerance. Immunol Rev. 2022 05; 307(1):5-11. PMID: 35301733.
      View in: PubMed
    11. Peterson JN, Boackle SA, Taitano SH, Sang A, Lang J, Kelly M, Rahkola JT, Miranda AM, Sheridan RM, Thurman JM, Rao VK, Torres RM, Pelanda R. Elevated Detection of Dual Antibody B Cells Identifies Lupus Patients With B Cell-Reactive VH4-34 Autoantibodies. Front Immunol. 2022; 13:795209. PMID: 35185888.
      View in: PubMed
    12. Pelanda R, Greaves SA, Alves da Costa T, Cedrone LM, Campbell ML, Torres RM. B-cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells. Immunol Rev. 2022 05; 307(1):12-26. PMID: 34997597.
      View in: PubMed
    13. Alves da Costa T, Peterson JN, Lang J, Shulman J, Liang X, Freed BM, Boackle SA, Lauzurica P, Torres RM, Pelanda R. Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice. Proc Natl Acad Sci U S A. 2021 04 20; 118(16). PMID: 33850015.
      View in: PubMed
    14. Mar?n-Jim?nez JA, Capasso A, Lewis MS, Bagby SM, Hartman SJ, Shulman J, Navarro NM, Yu H, Rivard CJ, Wang X, Barkow JC, Geng D, Kar A, Yingst A, Tufa DM, Dolan JT, Blatchford PJ, Freed BM, Torres RM, Davila E, Slansky JE, Pelanda R, Eckhardt SG, Messersmith WA, Diamond JR, Lieu CH, Verneris MR, Wang JH, Kiseljak-Vassiliades K, Pitts TM, Lang J. Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes. Front Immunol. 2021; 12:607282. PMID: 33854497.
      View in: PubMed
    15. Zeng F, Chen Z, Chen R, Shufesky WJ, Bandyopadhyay M, Camirand G, Oberbarnscheidt MH, Sullivan MLG, Baty CJ, Yang MQ, Calderon M, Stolz DB, Erdos G, Pelanda R, Brennan TV, Catz SD, Watkins SC, Larregina AT, Morelli AE. Graft-derived extracellular vesicles transported across subcapsular sinus macrophages elicit B cell alloimmunity after transplantation. Sci Transl Med. 2021 03 17; 13(585). PMID: 33731430.
      View in: PubMed
    16. Tentler JJ, Lang J, Capasso A, Kim DJ, Benaim E, Lee YB, Eisen A, Bagby SM, Hartman SJ, Yacob BW, Gittleman B, Pitts TM, Pelanda R, Eckhardt SG, Diamond JR. RX-5902, a novel ?-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer. BMC Cancer. 2020 Nov 04; 20(1):1063. PMID: 33148223.
      View in: PubMed
    17. Agazio A, Cimons J, Shotts KM, Guo K, Santiago ML, Pelanda R, Torres RM. Histone H2A-Reactive B Cells Are Functionally Anergic in Healthy Mice With Potential to Provide Humoral Protection Against HIV-1. Front Immunol. 2020; 11:1565. PMID: 32849530.
      View in: PubMed
    18. Alves da Costa T, Lang J, Torres RM, Pelanda R. The development of human immune system mice and their use to study tolerance and autoimmunity. J Transl Autoimmun. 2019 Dec; 2:100021. PMID: 32743507.
      View in: PubMed
    19. Allen TM, Brehm MA, Bridges S, Ferguson S, Kumar P, Mirochnitchenko O, Palucka K, Pelanda R, Sanders-Beer B, Shultz LD, Su L, PrabhuDas M. Humanized immune system mouse models: progress, challenges and opportunities. Nat Immunol. 2019 07; 20(7):770-774. PMID: 31160798.
      View in: PubMed
    20. Mathew D, Kremer KN, Strauch P, Tigyi G, Pelanda R, Torres RM. LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling. Front Immunol. 2019; 10:1159. PMID: 31231367.
      View in: PubMed
    21. Greaves SA, Peterson JN, Strauch P, Torres RM, Pelanda R. Active PI3K abrogates central tolerance in high-avidity autoreactive B cells. J Exp Med. 2019 05 06; 216(5):1135-1153. PMID: 30948496.
      View in: PubMed
    22. Capasso A, Lang J, Pitts TM, Jordan KR, Lieu CH, Davis SL, Diamond JR, Kopetz S, Barbee J, Peterson J, Freed BM, Yacob BW, Bagby SM, Messersmith WA, Slansky JE, Pelanda R, Eckhardt SG. Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts. J Immunother Cancer. 2019 02 08; 7(1):37. PMID: 30736857.
      View in: PubMed
    23. Coleman CB, Lang J, Sweet LA, Smith NA, Freed BM, Pan Z, Haverkos B, Pelanda R, Rochford R. Epstein-Barr Virus Type 2 Infects T Cells and Induces B Cell Lymphomagenesis in Humanized Mice. J Virol. 2018 11 01; 92(21). PMID: 30089703.
      View in: PubMed
    24. Sang A, Danhorn T, Peterson JN, Rankin AL, O'Connor BP, Leach SM, Torres RM, Pelanda R. Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus. Nat Commun. 2018 09 28; 9(1):3973. PMID: 30266981.
      View in: PubMed
    25. Greaves SA, Peterson JN, Torres RM, Pelanda R. Corrigendum: Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance. Front Immunol. 2018; 9:2218. PMID: 30323810.
      View in: PubMed
    26. Agazio AE, Pelanda R, Torres RM. Silencing of TLM B cells by chronic HIV infection. Nat Immunol. 2018 09; 19(9):902-903. PMID: 30104630.
      View in: PubMed
    27. Hobeika E, Dautzenberg M, Levit-Zerdoun E, Pelanda R, Reth M. Conditional Selection of B Cells in Mice With an Inducible B Cell Development. Front Immunol. 2018; 9:1806. PMID: 30127788.
      View in: PubMed
    28. Bednarek J, Traxinger B, Brigham D, Roach J, Orlicky D, Wang D, Pelanda R, Mack CL. Cytokine-Producing B Cells Promote Immune-Mediated Bile Duct Injury in Murine Biliary Atresia. Hepatology. 2018 11; 68(5):1890-1904. PMID: 29679373.
      View in: PubMed
    29. Greaves SA, Peterson JN, Torres RM, Pelanda R. Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance. Front Immunol. 2018; 9:707. PMID: 29686680.
      View in: PubMed
    30. Lang J, Zhang B, Kelly M, Peterson JN, Barbee J, Freed BM, Di Santo JP, Matsuda JL, Torres RM, Pelanda R. Replacing mouse BAFF with human BAFF does not improve B-cell maturation in hematopoietic humanized mice. Blood Adv. 2017 Dec 26; 1(27):2729-2741. PMID: 29296925.
      View in: PubMed
    31. Schroeder KMS, Agazio A, Strauch PJ, Jones ST, Thompson SB, Harper MS, Pelanda R, Santiago ML, Torres RM. Breaching peripheral tolerance promotes the production of HIV-1-neutralizing antibodies. J Exp Med. 2017 Aug 07; 214(8):2283-2302. PMID: 28698284.
      View in: PubMed
    32. Lang J, Ota T, Kelly M, Strauch P, Freed BM, Torres RM, Nemazee D, Pelanda R. Receptor editing and genetic variability in human autoreactive B cells. J Exp Med. 2016 Jan 11; 213(1):93-108. PMID: 26694971.
      View in: PubMed
    33. Hobeika E, Levit-Zerdoun E, Anastasopoulou V, Pohlmeyer R, Altmeier S, Alsadeq A, Dobenecker MW, Pelanda R, Reth M. CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk. EMBO J. 2015 Apr 01; 34(7):925-39. PMID: 25630702.
      View in: PubMed
    34. Teodorovic LS, Babolin C, Rowland SL, Greaves SA, Baldwin DP, Torres RM, Pelanda R. Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):E2797-806. PMID: 24958853.
      View in: PubMed
    35. Hu J, Oda SK, Shotts K, Donovan EE, Strauch P, Pujanauski LM, Victorino F, Al-Shami A, Fujiwara Y, Tigyi G, Oravecz T, Pelanda R, Torres RM. Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response. J Immunol. 2014 Jul 01; 193(1):85-95. PMID: 24890721.
      View in: PubMed
    36. Pelanda R. Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity? Curr Opin Immunol. 2014 Apr; 27:53-9. PMID: 24549093.
      View in: PubMed
    37. Oda SK, Strauch P, Fujiwara Y, Al-Shami A, Oravecz T, Tigyi G, Pelanda R, Torres RM. Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression. Cancer Immunol Res. 2013 Oct; 1(4):245-55. PMID: 24455753.
      View in: PubMed
    38. Feldman AG, Tucker RM, Fenner EK, Pelanda R, Mack CL. B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia. PLoS One. 2013; 8(8):e73644. PMID: 23991203.
      View in: PubMed
    39. Fuquay R, Renner B, Kulik L, McCullough JW, Amura C, Strassheim D, Pelanda R, Torres R, Thurman JM. Renal ischemia-reperfusion injury amplifies the humoral immune response. J Am Soc Nephrol. 2013 Jun; 24(7):1063-72. PMID: 23641055.
      View in: PubMed
    40. Rowland SL, Tuttle K, Torres RM, Pelanda R. Antigen and cytokine receptor signals guide the development of the na?ve mature B cell repertoire. Immunol Res. 2013 Mar; 55(1-3):231-40. PMID: 22941591.
      View in: PubMed
    41. Swanson CL, Pelanda R, Torres RM. Division of labor during primary humoral immunity. Immunol Res. 2013 Mar; 55(1-3):277-86. PMID: 22945808.
      View in: PubMed
    42. Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, Pelanda R. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 2013 Mar 01; 190(5):2090-101. PMID: 23335750.
      View in: PubMed
    43. Pujanauski LM, Janoff EN, McCarter MD, Pelanda R, Torres RM. Mouse marginal zone B cells harbor specificities similar to human broadly neutralizing HIV antibodies. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1422-7. PMID: 23288906.
      View in: PubMed
    44. Fournier EM, Velez MG, Leahy K, Swanson CL, Rubtsov AV, Torres RM, Pelanda R. Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice. J Exp Med. 2012 Sep 24; 209(10):1797-812. PMID: 22927551.
      View in: PubMed
    45. Hartney JM, Chu H, Pelanda R, Torres RM. Sub-chronic exposure to second hand smoke induces airspace leukocyte infiltration and decreased lung elastance. Front Physiol. 2012; 3:300. PMID: 22934051.
      View in: PubMed
    46. Larson JD, Thurman JM, Rubtsov AV, Claypool D, Marrack P, van Dyk LF, Torres RM, Pelanda R. Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):E1092-100. PMID: 22474381.
      View in: PubMed
    47. Pelanda R, Torres RM. Central B-cell tolerance: where selection begins. Cold Spring Harb Perspect Biol. 2012 Apr 01; 4(4):a007146. PMID: 22378602.
      View in: PubMed
    48. Teodorovic LS, Riccardi C, Torres RM, Pelanda R. Murine B cell development and antibody responses to model antigens are not impaired in the absence of the TNF receptor GITR. PLoS One. 2012; 7(2):e31632. PMID: 22328941.
      View in: PubMed
    49. Hartney JM, Gustafson CE, Bowler RP, Pelanda R, Torres RM. Thromboxane receptor signaling is required for fibronectin-induced matrix metalloproteinase 9 production by human and murine macrophages and is attenuated by the Arhgef1 molecule. J Biol Chem. 2011 Dec 30; 286(52):44521-31. PMID: 22086927.
      View in: PubMed
    50. Eschbach C, Bach MP, Fidler I, Pelanda R, K?hler F, Rajewsky K, Jumaa H. Efficient generation of B lymphocytes by recognition of self-antigens. Eur J Immunol. 2011 Aug; 41(8):2397-403. PMID: 21604259.
      View in: PubMed
    51. Lang J, Weiss N, Freed BM, Torres RM, Pelanda R. Generation of hematopoietic humanized mice in the newborn BALB/c-Rag2null Il2r?null mouse model: a multivariable optimization approach. Clin Immunol. 2011 Jul; 140(1):102-16. PMID: 21536497.
      View in: PubMed
    52. Santiago ML, Smith DS, Barrett BS, Montano M, Benitez RL, Pelanda R, Hasenkrug KJ, Greene WC. Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor. J Virol. 2011 Jan; 85(1):189-99. PMID: 20980520.
      View in: PubMed
    53. Rowland SL, Leahy KF, Halverson R, Torres RM, Pelanda R. BAFF receptor signaling aids the differentiation of immature B cells into transitional B cells following tonic BCR signaling. J Immunol. 2010 Oct 15; 185(8):4570-81. PMID: 20861359.
      View in: PubMed
    54. Swanson CL, Wilson TJ, Strauch P, Colonna M, Pelanda R, Torres RM. Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response. J Exp Med. 2010 Jul 05; 207(7):1485-500. PMID: 20566717.
      View in: PubMed
    55. Donovan EE, Pelanda R, Torres RM. S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development. Eur J Immunol. 2010 Mar; 40(3):688-98. PMID: 20039302.
      View in: PubMed
    56. Rowland SL, DePersis CL, Torres RM, Pelanda R. Ras activation of Erk restores impaired tonic BCR signaling and rescues immature B cell differentiation. J Exp Med. 2010 Mar 15; 207(3):607-21. PMID: 20176802.
      View in: PubMed
    57. Hartney JM, Brown J, Chu HW, Chang LY, Pelanda R, Torres RM. Arhgef1 regulates alpha5beta1 integrin-mediated matrix metalloproteinase expression and is required for homeostatic lung immunity. Am J Pathol. 2010 Mar; 176(3):1157-68. PMID: 20093499.
      View in: PubMed
    58. Pelanda R, Piccirillo CA. Tolerance, immune regulation, and autoimmunity: cells and cytokines that make a difference. Curr Opin Immunol. 2008 Dec; 20(6):629-31. PMID: 18977298.
      View in: PubMed
    59. Rubtsov AV, Swanson CL, Troy S, Strauch P, Pelanda R, Torres RM. TLR agonists promote marginal zone B cell activation and facilitate T-dependent IgM responses. J Immunol. 2008 Mar 15; 180(6):3882-8. PMID: 18322196.
      View in: PubMed
    60. Hu J, Strauch P, Rubtsov A, Donovan EE, Pelanda R, Torres RM. Lsc activity is controlled by oligomerization and regulates integrin adhesion. Mol Immunol. 2008 Apr; 45(7):1825-36. PMID: 18157933.
      View in: PubMed
    61. Velez MG, Kane M, Liu S, Gauld SB, Cambier JC, Torres RM, Pelanda R. Ig allotypic inclusion does not prevent B cell development or response. J Immunol. 2007 Jul 15; 179(2):1049-57. PMID: 17617597.
      View in: PubMed
    62. Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y. Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nat Immunol. 2007 Jul; 8(7):715-22. PMID: 17546032.
      View in: PubMed
    63. Liu H, Schmidt-Supprian M, Shi Y, Hobeika E, Barteneva N, Jumaa H, Pelanda R, Reth M, Skok J, Rajewsky K, Shi Y. Yin Yang 1 is a critical regulator of B-cell development. Genes Dev. 2007 May 15; 21(10):1179-89. PMID: 17504937.
      View in: PubMed
    64. Brown JP, Taube C, Miyahara N, Koya T, Pelanda R, Gelfand EW, Torres RM. Arhgef1 is required by T cells for the development of airway hyperreactivity and inflammation. Am J Respir Crit Care Med. 2007 Jul 01; 176(1):10-9. PMID: 17463415.
      View in: PubMed
    65. Hobeika E, Thiemann S, Storch B, Jumaa H, Nielsen PJ, Pelanda R, Reth M. Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13789-94. PMID: 16940357.
      View in: PubMed
    66. Sasaki Y, Derudder E, Hobeika E, Pelanda R, Reth M, Rajewsky K, Schmidt-Supprian M. Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity. 2006 Jun; 24(6):729-739. PMID: 16782029.
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    67. Pelanda R, Torres RM. Receptor editing for better or for worse. Curr Opin Immunol. 2006 Apr; 18(2):184-90. PMID: 16460922.
      View in: PubMed
    68. Rubtsov A, Strauch P, Digiacomo A, Hu J, Pelanda R, Torres RM. Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response. Immunity. 2005 Nov; 23(5):527-38. PMID: 16286020.
      View in: PubMed
    69. Liu S, Velez MG, Humann J, Rowland S, Conrad FJ, Halverson R, Torres RM, Pelanda R. Receptor editing can lead to allelic inclusion and development of B cells that retain antibodies reacting with high avidity autoantigens. J Immunol. 2005 Oct 15; 175(8):5067-76. PMID: 16210610.
      View in: PubMed
    70. Novobrantseva T, Xu S, Tan JE, Maruyama M, Schwers S, Pelanda R, Lam KP. Stochastic pairing of Ig heavy and light chains frequently generates B cell antigen receptors that are subject to editing in vivo. Int Immunol. 2005 Apr; 17(4):343-50. PMID: 15710909.
      View in: PubMed
    71. Galler GR, Mundt C, Parker M, Pelanda R, M?rtensson IL, Winkler TH. Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components. J Exp Med. 2004 Jun 07; 199(11):1523-32. PMID: 15173209.
      View in: PubMed
    72. Halverson R, Torres RM, Pelanda R. Receptor editing is the main mechanism of B cell tolerance toward membrane antigens. Nat Immunol. 2004 Jun; 5(6):645-50. PMID: 15156139.
      View in: PubMed
    73. Heinrich AC, Pelanda R, Klingm?ller U. A mouse model for visualization and conditional mutations in the erythroid lineage. Blood. 2004 Aug 01; 104(3):659-66. PMID: 15090451.
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    74. Pelanda R, Braun U, Hobeika E, Nussenzweig MC, Reth M. B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta. J Immunol. 2002 Jul 15; 169(2):865-72. PMID: 12097390.
      View in: PubMed
    75. Pelanda R, Hobeika E, Kurokawa T, Zhang Y, Kuppig S, Reth M. Cre recombinase-controlled expression of the mb-1 allele. Genesis. 2002 Feb; 32(2):154-7. PMID: 11857807.
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    76. Braun U, Rajewsky K, Pelanda R. Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7429-34. PMID: 10829061.
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    77. Korganow AS, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, Degott C, Kikutani H, Rajewsky K, Pasquali JL, Benoist C, Mathis D. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity. 1999 Apr; 10(4):451-61. PMID: 10229188.
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    78. Novobrantseva TI, Martin VM, Pelanda R, M?ller W, Rajewsky K, Ehlich A. Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice. J Exp Med. 1999 Jan 04; 189(1):75-88. PMID: 9874565.
      View in: PubMed
    79. Mostoslavsky R, Singh N, Kirillov A, Pelanda R, Cedar H, Chess A, Bergman Y. Kappa chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 1998 Jun 15; 12(12):1801-11. PMID: 9637682.
      View in: PubMed
    80. Casellas R, Nussenzweig A, Wuerffel R, Pelanda R, Reichlin A, Suh H, Qin XF, Besmer E, Kenter A, Rajewsky K, Nussenzweig MC. Ku80 is required for immunoglobulin isotype switching. EMBO J. 1998 Apr 15; 17(8):2404-11. PMID: 9545251.
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    81. Pelanda R, Schwers S, Sonoda E, Torres RM, Nemazee D, Rajewsky K. Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity. 1997 Dec; 7(6):765-75. PMID: 9430222.
      View in: PubMed
    82. Papavasiliou F, Casellas R, Suh H, Qin XF, Besmer E, Pelanda R, Nemazee D, Rajewsky K, Nussenzweig MC. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science. 1997 Oct 10; 278(5336):298-301. PMID: 9323210.
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    83. Pelanda R, Schaal S, Torres RM, Rajewsky K. A prematurely expressed Ig(kappa) transgene, but not V(kappa)J(kappa) gene segment targeted into the Ig(kappa) locus, can rescue B cell development in lambda5-deficient mice. Immunity. 1996 Sep; 5(3):229-39. PMID: 8808678.
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    84. Pelanda R, Vanoni MA, Perego M, Piubelli L, Galizzi A, Curti B, Zanetti G. Glutamate synthase genes of the diazotroph Azospirillum brasilense. Cloning, sequencing, and analysis of functional domains. J Biol Chem. 1993 Feb 15; 268(5):3099-106. PMID: 8428988.
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