 Self Tolerance
"Self Tolerance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The normal lack of the ability to produce an immunological response to autologous (self) antigens. A breakdown of self tolerance leads to autoimmune diseases. The ability to recognize the difference between self and non-self is the prime function of the immune system.
| Descriptor ID |
D017634
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| MeSH Number(s) |
G12.535.425.800
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| Concept/Terms |
Self Tolerance- Self Tolerance
- Self Tolerances
- Tolerance, Self
- Tolerances, Self
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Below are MeSH descriptors whose meaning is more general than "Self Tolerance".
Below are MeSH descriptors whose meaning is more specific than "Self Tolerance".
This graph shows the total number of publications written about "Self Tolerance" by people in this website by year, and whether "Self Tolerance" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 2 | 2 | | 2008 | 2 | 1 | 3 | | 2009 | 0 | 2 | 2 | | 2010 | 2 | 0 | 2 | | 2011 | 1 | 1 | 2 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2017 | 0 | 2 | 2 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Self Tolerance" by people in Profiles.
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Slight-Webb S, Bourn RL, Holers VM, James JA. Shared and unique immune alterations in pre-clinical autoimmunity. Curr Opin Immunol. 2019 12; 61:60-68.
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Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM. Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins. J Immunol. 2018 01 01; 200(1):316-326.
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Vogel AL, Knier B, Lammens K, Kalluri SR, Kuhlmann T, Bennett JL, Korn T. Deletional tolerance prevents AQP4-directed autoimmunity in mice. Eur J Immunol. 2017 03; 47(3):458-469.
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Atkinson C, Qiao F, Yang X, Zhu P, Reaves N, Kulik L, Goddard M, Holers VM, Tomlinson S. Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury. Circulation. 2015 Mar 31; 131(13):1171-80.
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Galvin KC, Dyck L, Marshall NA, Stefanska AM, Walsh KP, Moran B, Higgins SC, Dungan LS, Mills KH. Blocking retinoic acid receptor-a enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells. Cancer Immunol Immunother. 2013 Jul; 62(7):1273-82.
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Verneris MR. Natural killer cells and regulatory T cells: how to manipulate a graft for optimal GVL. Hematology Am Soc Hematol Educ Program. 2013; 2013:335-41.
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Aviszus K, Macleod MK, Kirchenbaum GA, Detanico TO, Heiser RA, St Clair JB, Guo W, Wysocki LJ. Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells. J Immunol. 2012 Nov 01; 189(9):4275-83.
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Banninger GP, Cha S, Said MS, Pauley KM, Carter CJ, Onate M, Pauley BA, Anderson SM, Reyland ME. Loss of PKCd results in characteristics of Sj?gren's syndrome including salivary gland dysfunction. Oral Dis. 2011 Sep; 17(6):601-9.
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Detanico T, Heiser RA, Aviszus K, Bonorino C, Wysocki LJ. Self-tolerance checkpoints in CD4 T cells specific for a peptide derived from the B cell antigen receptor. J Immunol. 2011 Jul 01; 187(1):82-91.
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Gapin L. iNKT cell autoreactivity: what is 'self' and how is it recognized? Nat Rev Immunol. 2010 Apr; 10(4):272-7.
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