 Protein Deglycase DJ-1
"Protein Deglycase DJ-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.
| Descriptor ID |
D000071617
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| MeSH Number(s) |
D08.811.277.785 D12.776.637.875
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| Concept/Terms |
Protein Deglycase DJ-1- Protein Deglycase DJ-1
- DJ-1, Protein Deglycase
- DJ-1-PARK7 Protein
- DJ 1 PARK7 Protein
- DJ-1 Protein
- DJ 1 Protein
- Parkinson Protein 7
- DJ1 Protein
- PARK7 Protein
- Parkinsonism Associated Deglycase
- Deglycase, Parkinsonism Associated
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Below are MeSH descriptors whose meaning is more general than "Protein Deglycase DJ-1".
Below are MeSH descriptors whose meaning is more specific than "Protein Deglycase DJ-1".
This graph shows the total number of publications written about "Protein Deglycase DJ-1" by people in this website by year, and whether "Protein Deglycase DJ-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Deglycase DJ-1" by people in Profiles.
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Bahmed K, Boukhenouna S, Karim L, Andrews T, Lin J, Powers R, Wilson MA, Lin CR, Messier E, Reisdorph N, Powell RL, Tang HY, Mason RJ, Criner GJ, Kosmider B. The effect of cysteine oxidation on DJ-1 cytoprotective function in human alveolar type II cells. Cell Death Dis. 2019 09 02; 10(9):638.
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Zhou W, Barkow JC, Freed CR. Running wheel exercise reduces a-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease. PLoS One. 2017; 12(12):e0190160.
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Bahmed K, Messier EM, Zhou W, Tuder RM, Freed CR, Chu HW, Kelsen SG, Bowler RP, Mason RJ, Kosmider B. DJ-1 Modulates Nuclear Erythroid 2-Related Factor-2-Mediated Protection in Human Primary Alveolar Type II Cells in Smokers. Am J Respir Cell Mol Biol. 2016 09; 55(3):439-49.
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Klawitter J, Klawitter J, Agardi E, Corby K, Leibfritz D, Lowes BD, Christians U, Seres T. Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy. Cardiovasc Res. 2013 Jan 01; 97(1):66-76.
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Zhou W, Bercury K, Cummiskey J, Luong N, Lebin J, Freed CR. Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease. J Biol Chem. 2011 Apr 29; 286(17):14941-51.
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Malhotra D, Thimmulappa R, Navas-Acien A, Sandford A, Elliott M, Singh A, Chen L, Zhuang X, Hogg J, Pare P, Tuder RM, Biswal S. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med. 2008 09 15; 178(6):592-604.
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Zhou W, Freed CR. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. J Biol Chem. 2005 Dec 30; 280(52):43150-8.
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