 Gene Rearrangement, B-Lymphocyte
"Gene Rearrangement, B-Lymphocyte" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ordered rearrangement of B-lymphocyte variable gene regions coding for the IMMUNOGLOBULIN CHAINS, thereby contributing to antibody diversity. It occurs during the differentiation of the IMMATURE B-LYMPHOCYTES.
| Descriptor ID |
D015322
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| MeSH Number(s) |
G05.344.401 G12.500.274
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| Concept/Terms |
Gene Rearrangement, B-Lymphocyte- Gene Rearrangement, B-Lymphocyte
- Gene Rearrangement, B Lymphocyte
- B-Lymphocyte Gene Rearrangement
- B Lymphocyte Gene Rearrangement
- B-Lymphocyte Gene Rearrangements
- Gene Rearrangements, B-Lymphocyte
- Rearrangement, B-Lymphocyte Gene
- Rearrangements, B-Lymphocyte Gene
- Gene Rearrangement, B-Cell
- B-Cell Gene Rearrangements
- Gene Rearrangement, B Cell
- Gene Rearrangements, B-Cell
- Rearrangement, B-Cell Gene
- Rearrangements, B-Cell Gene
- B-Cell Gene Rearrangement
- B Cell Gene Rearrangement
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Below are MeSH descriptors whose meaning is more general than "Gene Rearrangement, B-Lymphocyte".
Below are MeSH descriptors whose meaning is more specific than "Gene Rearrangement, B-Lymphocyte".
This graph shows the total number of publications written about "Gene Rearrangement, B-Lymphocyte" by people in this website by year, and whether "Gene Rearrangement, B-Lymphocyte" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2007 | 3 | 0 | 3 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gene Rearrangement, B-Lymphocyte" by people in Profiles.
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Benhamou D, Labi V, Getahun A, Benchetrit E, Dowery R, Rajewsky K, Cambier JC, Melamed D. The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development. Front Immunol. 2018; 9:2715.
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Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 2009 Jul 09; 460(7252):231-6.
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Wang JH, Alt FW, Gostissa M, Datta A, Murphy M, Alimzhanov MB, Coakley KM, Rajewsky K, Manis JP, Yan CT. Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. J Exp Med. 2008 Dec 22; 205(13):3079-90.
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Matthews AG, Kuo AJ, Ram?n-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature. 2007 Dec 13; 450(7172):1106-10.
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Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y. Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nat Immunol. 2007 Jul; 8(7):715-22.
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Liu H, Schmidt-Supprian M, Shi Y, Hobeika E, Barteneva N, Jumaa H, Pelanda R, Reth M, Skok J, Rajewsky K, Shi Y. Yin Yang 1 is a critical regulator of B-cell development. Genes Dev. 2007 May 15; 21(10):1179-89.
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Liu S, Velez MG, Humann J, Rowland S, Conrad FJ, Halverson R, Torres RM, Pelanda R. Receptor editing can lead to allelic inclusion and development of B cells that retain antibodies reacting with high avidity autoantigens. J Immunol. 2005 Oct 15; 175(8):5067-76.
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Shapiro GS, Wysocki LJ. DNA target motifs of somatic mutagenesis in antibody genes. Crit Rev Immunol. 2002; 22(3):183-200.
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Buhl AM, Nemazee D, Cambier JC, Rickert R, Hertz M. B-cell antigen receptor competence regulates B-lymphocyte selection and survival. Immunol Rev. 2000 Aug; 176:141-53.
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Papavasiliou F, Casellas R, Suh H, Qin XF, Besmer E, Pelanda R, Nemazee D, Rajewsky K, Nussenzweig MC. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science. 1997 Oct 10; 278(5336):298-301.
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