 Immunoglobulin Idiotypes
"Immunoglobulin Idiotypes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.
| Descriptor ID |
D007130
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| MeSH Number(s) |
D12.644.541.500.745 D12.776.124.486.485.680.745 D12.776.124.790.651.680.745 D12.776.377.715.548.680.745 D23.050.550.750 G02.111.570.060.425.580 G12.500.450
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| Concept/Terms |
Immunoglobulin Idiotypes- Immunoglobulin Idiotypes
- Idiotype, Immunoglobulin
- Immunoglobulin Idiotype
- Idiotypes, Immunoglobulin
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Idiotypes".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Idiotypes".
This graph shows the total number of publications written about "Immunoglobulin Idiotypes" by people in this website by year, and whether "Immunoglobulin Idiotypes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immunoglobulin Idiotypes" by people in Profiles.
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Phuan PW, Anderson MO, Tradtrantip L, Zhang H, Tan J, Lam C, Bennett JL, Verkman AS. A small-molecule screen yields idiotype-specific blockers of neuromyelitis optica immunoglobulin G binding to aquaporin-4. J Biol Chem. 2012 Oct 26; 287(44):36837-44.
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Basak S, Birebent B, Purev E, Somasundaram R, Maruyama H, Zaloudik J, Swoboda R, Strittmatter W, Li W, Luckenbach A, Song H, Li J, Sproesser K, Guerry D, Nair S, Furukawa K, Herlyn D. Induction of cellular immunity by anti-idiotypic antibodies mimicking GD2 ganglioside. Cancer Immunol Immunother. 2003 Mar; 52(3):145-54.
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Johnson SA, Rozzo SJ, Cambier JC. Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire. J Immunol. 2002 May 15; 168(10):5014-23.
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Birebent B, Koido T, Mitchell E, Li W, Somasundaram R, Purev E, Hoey D, Mastrangelo M, Maguire H, Harris DT, Nair S, Cai E, Herlyn D. Anti-idiotypic antibody (ab2) vaccines: coupling of Ab2 BR3E4 to KLH increases humoral and/or cellular immune responses in animals and colorectal cancer patients. J Cancer Res Clin Oncol. 2001 Oct; 127 Suppl 2:R27-33.
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Valderrama R, Eggers AE, Moomjy M, Kao PN, Michl J. Treatment of experimental myasthenia with autologous idiotypes linked to muramyl dipeptide. Clin Exp Immunol. 1988 Jul; 73(1):123-7.
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Gefter M, Marrack P. Immunology: development and modification of the lymphocyte repertoire. Nature. 1986 May 8-14; 321(6066):116-8.
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Foon KA, Schroff RW, Bunn PA. Clinical applications of monoclonal antibodies for patients with leukemia and lymphoma. Prog Clin Biol Res. 1986; 211:265-84.
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Kawahara DJ, Marrack P, Kappler JW. H-2-linked Ir gene control of VH determinant(s)-specific helper T cells. J Mol Cell Immunol. 1986; 2(5):255-64.
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Butler JE, Cambier JC, Klobasa F. Identification and characterization of a hapten-modifiable TEPC 15 cross-reactive idiotype in swine. Mol Immunol. 1985 Oct; 22(10):1159-68.
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Yag?e J, White J, Coleclough C, Kappler J, Palmer E, Marrack P. The T cell receptor: the alpha and beta chains define idiotype, and antigen and MHC specificity. Cell. 1985 Aug; 42(1):81-7.
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