 Gene Rearrangement, B-Lymphocyte, Light Chain
"Gene Rearrangement, B-Lymphocyte, Light Chain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ordered rearrangement of B-lymphocyte variable gene regions coding for the kappa or lambda IMMUNOGLOBULIN LIGHT CHAINS, thereby contributing to antibody diversity. It occurs during the second stage of differentiation of the IMMATURE B-LYMPHOCYTES.
| Descriptor ID |
D015328
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| MeSH Number(s) |
G05.344.401.601 G12.500.274.601
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| Concept/Terms |
Gene Rearrangement, B-Lymphocyte, Light Chain- Gene Rearrangement, B-Lymphocyte, Light Chain
- B-Cell Light Chain Gene Rearrangement
- B-Lymphocyte Light Chain Gene Rearrangement
- B Cell Light Chain Gene Rearrangement
- B Lymphocyte Light Chain Gene Rearrangement
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Below are MeSH descriptors whose meaning is more general than "Gene Rearrangement, B-Lymphocyte, Light Chain".
Below are MeSH descriptors whose meaning is more specific than "Gene Rearrangement, B-Lymphocyte, Light Chain".
This graph shows the total number of publications written about "Gene Rearrangement, B-Lymphocyte, Light Chain" by people in this website by year, and whether "Gene Rearrangement, B-Lymphocyte, Light Chain" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 2 | 0 | 2 | | 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Gene Rearrangement, B-Lymphocyte, Light Chain" by people in Profiles.
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Owens GP, Ritchie AM, Burgoon MP, Williamson RA, Corboy JR, Gilden DH. Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid. J Immunol. 2003 Sep 01; 171(5):2725-33.
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Mostoslavsky R, Singh N, Kirillov A, Pelanda R, Cedar H, Chess A, Bergman Y. Kappa chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 1998 Jun 15; 12(12):1801-11.
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Casellas R, Nussenzweig A, Wuerffel R, Pelanda R, Reichlin A, Suh H, Qin XF, Besmer E, Kenter A, Rajewsky K, Nussenzweig MC. Ku80 is required for immunoglobulin isotype switching. EMBO J. 1998 Apr 15; 17(8):2404-11.
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Melamed D, Benschop RJ, Cambier JC, Nemazee D. Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell. 1998 Jan 23; 92(2):173-82.
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Gemma NW, Lovell MA, Bringelsen KA, Williams ME. Lineage alteration in precursor B cell acute lymphoblastic leukemia following T cell lymphoblastic lymphoma. Leukemia. 1992 Dec; 6(12):1305-9.
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