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Brian J Day

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
    Collapse research activities and funding
    R21ES032951     (BEBARTA, VIKHYAT S;DAY, BRIAN J)Aug 18, 2021 - Jul 31, 2023
    NIH
    Repurposing thiosulfate for chlorine gas exposure
    Role: Principal Investigator
    R01HL141146     (DAY, BRIAN J ;HONDAL, ROBERT J)Jan 1, 2019 - Nov 30, 2023
    NIH
    Selenocyanate as a novel treatment of cystic fibrosis lung disease
    Role: Principal Investigator
    U01ES029430     (DAY, BRIAN J)Sep 1, 2018 - May 31, 2024
    NIH
    Optimization of AEOL10150 treatment of sulfur mustard-induced lung toxidrome in a pig model
    Role: Principal Investigator
    R01ES017582     (DAY, BRIAN J)Jul 1, 2009 - Mar 31, 2015
    NIH
    Targeting Oxidative Stress in Chronic Beryllium Disease
    Role: Principal Investigator
    R01HL084469     (DAY, BRIAN J)Dec 1, 2007 - Nov 30, 2013
    NIH
    Adaptive glutathione responses to cigarette smoke in COPD
    Role: Principal Investigator
    R01HL075523     (DAY, BRIAN J)Dec 15, 2003 - Nov 30, 2008
    NIH
    Glutathione transport, oxidative stress and lung injury
    Role: Principal Investigator
    R01ES012504     (DAY, BRIAN J)Aug 4, 2003 - May 31, 2008
    NIH
    Role of Oxidatve Stress in Chronic Beryllium Disease
    Role: Principal Investigator
    R01HL059602     (DAY, BRIAN J)Sep 30, 1997 - Aug 31, 2002
    NIH
    SOMATIC MTDNA MUTATIONS AND PULMONARY FIBROSIS
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Liang LP, Pearson-Smith JN, Day BJ, Patel M. Novel Catalytic Antioxidant Formulation Decreases Oxidative Stress, Neuroinflammation and Cognitive Dysfunction in a Model of Nerve Agent Intoxication. J Pharmacol Exp Ther. 2024 01 17; 388(2):358-366. PMID: 37652711.
      View in: PubMed
    2. Cervantes D, Schaunaman N, Downey GP, Chu HW, Day BJ. Desert particulate matter from Afghanistan increases airway obstruction in human distal lungs exposed to type 2 cytokine IL-13. Front Med (Lausanne). 2023; 10:1177665. PMID: 37448802.
      View in: PubMed
    3. Crue T, Lee GY, Peng JY, Schaunaman N, Agraval H, Day BJ, Dimasuay KG, Cervantes D, Nouri H, Nichols T, Hartsoe P, Numata M, Petrache I, Chu HW. Single cell RNA-sequencing of human precision-cut lung slices: A novel approach to study the effect of vaping and viral infection on lung health. Innate Immun. 2023 07; 29(5):61-70. PMID: 37306239.
      View in: PubMed
    4. Agraval H, Crue T, Schaunaman N, Numata M, Day BJ, Chu HW. Electronic Cigarette Exposure Increases the Severity of Influenza a Virus Infection via TRAIL Dysregulation in Human Precision-Cut Lung Slices. Int J Mol Sci. 2023 Feb 21; 24(5). PMID: 36901724.
      View in: PubMed
    5. Day BJ, Min E, Huang J, Stanley C. The Use of Thiocyanate Formulations to Create Manganese Porphyrin Antioxidants That Supplement Innate Immunity. Antioxidants (Basel). 2022 Jun 25; 11(7). PMID: 35883743.
      View in: PubMed
    6. Schaunaman N, Crue T, Cervantes D, Schweitzer K, Robbins H, Day BJ, Numata M, Petrache I, Chu HW. Electronic cigarette vapor exposure exaggerates the pro-inflammatory response during influenza A viral infection in human distal airway epithelium. Arch Toxicol. 2022 08; 96(8):2319-2328. PMID: 35672461.
      View in: PubMed
    7. Berman R, Rose CS, Downey GP, Day BJ, Chu HW. Role of Particulate Matter from Afghanistan and Iraq in Deployment-Related Lung Disease. Chem Res Toxicol. 2021 12 20; 34(12):2408-2423. PMID: 34808040.
      View in: PubMed
    8. Berman R, Min E, Huang J, Kopf K, Downey GP, Riemondy K, Smith HA, Rose CS, Seibold MA, Chu HW, Day BJ. Single-Cell RNA Sequencing Reveals a Unique Monocyte Population in Bronchoalveolar Lavage Cells of Mice Challenged With Afghanistan Particulate Matter and Allergen. Toxicol Sci. 2021 08 03; 182(2):297-309. PMID: 34051097.
      View in: PubMed
    9. Liang LP, Fulton R, Bradshaw-Pierce EL, Pearson-Smith J, Day BJ, Patel M. Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism. J Pharmacol Exp Ther. 2021 04; 377(1):1-10. PMID: 33500265.
      View in: PubMed
    10. Berman R, Kopf KW, Min E, Huang J, Downey GP, Alam R, Chu HW, Day BJ. IL-33/ST2 signaling modulates Afghanistan particulate matter induced airway hyperresponsiveness in mice. Toxicol Appl Pharmacol. 2020 10 01; 404:115186. PMID: 32777237.
      View in: PubMed
    11. Gellatly S, Pavelka N, Crue T, Schweitzer KS, Day BJ, Min E, Numata M, Voelker DR, Scruggs A, Petrache I, Chu HW. Nicotine-Free e-Cigarette Vapor Exposure Stimulates IL6 and Mucin Production in Human Primary Small Airway Epithelial Cells. J Inflamm Res. 2020; 13:175-185. PMID: 32368126.
      View in: PubMed
    12. Dickerhof N, Huang J, Min E, Micha?lsson E, Lindstedt EL, Pearson JF, Kettle AJ, Day BJ. Myeloperoxidase inhibition decreases morbidity and oxidative stress in mice with cystic fibrosis-like lung inflammation. Free Radic Biol Med. 2020 05 20; 152:91-99. PMID: 32142878.
      View in: PubMed
    13. Day BJ, Bratcher PE, Chandler JD, Kilgore MB, Min E, LiPuma JJ, Hondal RJ, Nichols DP. The thiocyanate analog selenocyanate is a more potent antimicrobial pro-drug that also is selectively detoxified by the host. Free Radic Biol Med. 2020 01; 146:324-332. PMID: 31740228.
      View in: PubMed
    14. Day BJ. The science of licking your wounds: Function of oxidants in the innate immune system. Biochem Pharmacol. 2019 05; 163:451-457. PMID: 30876918.
      View in: PubMed
    15. Berman R, Downey GP, Dakhama A, Day BJ, Chu HW. Afghanistan Particulate Matter Enhances Pro-Inflammatory Responses in IL-13-Exposed Human Airway Epithelium via TLR2 Signaling. Toxicol Sci. 2018 Dec 01; 166(2):345-353. PMID: 30169750.
      View in: PubMed
    16. Liang LP, Pearson-Smith JN, Huang J, Day BJ, Patel M. Neuroprotective effects of a catalytic antioxidant in a rat nerve agent model. Redox Biol. 2019 01; 20:275-284. PMID: 30384261.
      View in: PubMed
    17. Liang LP, Pearson-Smith JN, Huang J, McElroy P, Day BJ, Patel M. Neuroprotective Effects of AEOL10150 in a Rat Organophosphate Model. Toxicol Sci. 2018 04 01; 162(2):611-621. PMID: 29272548.
      View in: PubMed
    18. Day BJ, Huang J, Barkes BQ, Gillespie M, Li L, Maier LA. 5-Aminosalicylic Acid Modulates the Immune Response in Chronic Beryllium Disease Subjects. Lung. 2018 02; 196(1):103-114. PMID: 29080069.
      View in: PubMed
    19. McElroy PB, Liang LP, Day BJ, Patel M. Scavenging reactive oxygen species inhibits status epilepticus-induced neuroinflammation. Exp Neurol. 2017 12; 298(Pt A):13-22. PMID: 28822838.
      View in: PubMed
    20. Pearson-Smith JN, Liang LP, Rowley SD, Day BJ, Patel M. Oxidative Stress Contributes to Status Epilepticus Associated Mortality. Neurochem Res. 2017 Jul; 42(7):2024-2032. PMID: 28462450.
      View in: PubMed
    21. Liang LP, Huang J, Fulton R, Pearson-Smith JN, Day BJ, Patel M. Pre-clinical therapeutic development of a series of metalloporphyrins for Parkinson's disease. Toxicol Appl Pharmacol. 2017 07 01; 326:34-42. PMID: 28400118.
      View in: PubMed
    22. McElroy PB, Sri Hari A, Day BJ, Patel M. Post-translational Activation of Glutamate Cysteine Ligase with Dimercaprol: A NOVEL MECHANISM OF INHIBITING NEUROINFLAMMATION IN VITRO. J Biol Chem. 2017 03 31; 292(13):5532-5545. PMID: 28202547.
      View in: PubMed
    23. McElroy CS, Min E, Huang J, Loader JE, Hendry-Hofer TB, Garlick RB, Rioux JS, Veress LA, Smith R, Osborne C, Anderson DR, Holmes WW, Paradiso DC, White CW, Day BJ. From the Cover: Catalytic Antioxidant Rescue of Inhaled Sulfur Mustard Toxicity. Toxicol Sci. 2016 12; 154(2):341-353. PMID: 27605419.
      View in: PubMed
    24. Hamzeh N, Li L, Barkes B, Huang J, Canono B, Gillespie M, Maier L, Day B. The effect of an oral anti-oxidant, N-Acetyl-cysteine, on inflammatory and oxidative markers in pulmonary sarcoidosis. Respir Med. 2016 Mar; 112:106-11. PMID: 26831541.
      View in: PubMed
    25. McElroy CS, Day BJ. Antioxidants as potential medical countermeasures for chemical warfare agents and toxic industrial chemicals. Biochem Pharmacol. 2016 Jan 15; 100:1-11. PMID: 26476351.
      View in: PubMed
    26. Chandler JD, Min E, Huang J, McElroy CS, Dickerhof N, Mocatta T, Fletcher AA, Evans CM, Liang L, Patel M, Kettle AJ, Nichols DP, Day BJ. Antiinflammatory and Antimicrobial Effects of Thiocyanate in a Cystic Fibrosis Mouse Model. Am J Respir Cell Mol Biol. 2015 Aug; 53(2):193-205. PMID: 25490247.
      View in: PubMed
    27. Pearson JN, Rowley S, Liang LP, White AM, Day BJ, Patel M. Reactive oxygen species mediate cognitive deficits in experimental temporal lobe epilepsy. Neurobiol Dis. 2015 Oct; 82:289-297. PMID: 26184893.
      View in: PubMed
    28. Gould NS, Min E, Huang J, Chu HW, Good J, Martin RJ, Day BJ. Glutathione Depletion Accelerates Cigarette Smoke-Induced Inflammation and Airspace Enlargement. Toxicol Sci. 2015 Oct; 147(2):466-74. PMID: 26149495.
      View in: PubMed
    29. Ahmad S, Ahmad A, Hendry-Hofer TB, Loader JE, Claycomb WC, Mozziconacci O, Sch?neich C, Reisdorph N, Powell RL, Chandler JD, Day BJ, Veress LA, White CW. Sarcoendoplasmic reticulum Ca(2+) ATPase. A critical target in chlorine inhalation-induced cardiotoxicity. Am J Respir Cell Mol Biol. 2015 Apr; 52(4):492-502. PMID: 25188881.
      View in: PubMed
    30. Chandler JD, Day BJ. Biochemical mechanisms and therapeutic potential of pseudohalide thiocyanate in human health. Free Radic Res. 2015 Jun; 49(6):695-710. PMID: 25564094.
      View in: PubMed
    31. Rowley S, Liang LP, Fulton R, Shimizu T, Day B, Patel M. Mitochondrial respiration deficits driven by reactive oxygen species in experimental temporal lobe epilepsy. Neurobiol Dis. 2015 Mar; 75:151-8. PMID: 25600213.
      View in: PubMed
    32. Aydintug MK, Zhang L, Wang C, Liang D, Wands JM, Michels AW, Hirsch B, Day BJ, Zhang G, Sun D, Eisenbarth GS, O'Brien RL, Born WK. ?d T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation. Mol Immunol. 2014 Aug; 60(2):116-28. PMID: 24853397.
      View in: PubMed
    33. Tewari-Singh N, Inturi S, Jain AK, Agarwal C, Orlicky DJ, White CW, Agarwal R, Day BJ. Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects. Free Radic Biol Med. 2014 Jul; 72:285-95. PMID: 24815113.
      View in: PubMed
    34. Szak?cs G, Hall MD, Gottesman MM, Boumendjel A, Kachadourian R, Day BJ, Baubichon-Cortay H, Di Pietro A. Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance. Chem Rev. 2014 Jun 11; 114(11):5753-74. PMID: 24758331.
      View in: PubMed
    35. Day BJ. Antioxidant therapeutics: Pandora's box. Free Radic Biol Med. 2014 Jan; 66:58-64. PMID: 23856377.
      View in: PubMed
    36. Shalaby KH, Allard-Coutu A, O'Sullivan MJ, Nakada E, Qureshi ST, Day BJ, Martin JG. Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4-TRIF pathway. J Immunol. 2013 Jul 15; 191(2):922-33. PMID: 23776177.
      View in: PubMed
    37. Messier EM, Day BJ, Bahmed K, Kleeberger SR, Tuder RM, Bowler RP, Chu HW, Mason RJ, Kosmider B. N-acetylcysteine protects murine alveolar type II cells from cigarette smoke injury in a nuclear erythroid 2-related factor-2-independent manner. Am J Respir Cell Mol Biol. 2013 May; 48(5):559-67. PMID: 23492188.
      View in: PubMed
    38. Chandler JD, Nichols DP, Nick JA, Hondal RJ, Day BJ. Selective metabolism of hypothiocyanous acid by mammalian thioredoxin reductase promotes lung innate immunity and antioxidant defense. J Biol Chem. 2013 Jun 21; 288(25):18421-8. PMID: 23629660.
      View in: PubMed
    39. Lopert P, Day BJ, Patel M. Thioredoxin reductase deficiency potentiates oxidative stress, mitochondrial dysfunction and cell death in dopaminergic cells. PLoS One. 2012; 7(11):e50683. PMID: 23226354.
      View in: PubMed
    40. Fernandez-Boyanapalli R, Goleva E, Kolakowski C, Min E, Day B, Leung DY, Riches DW, Bratton DL, Sutherland ER. Obesity impairs apoptotic cell clearance in asthma. J Allergy Clin Immunol. 2013 Apr; 131(4):1041-7, 1047.e1-3. PMID: 23154082.
      View in: PubMed
    41. Chandler JD, Day BJ. Thiocyanate: a potentially useful therapeutic agent with host defense and antioxidant properties. Biochem Pharmacol. 2012 Dec 01; 84(11):1381-7. PMID: 22968041.
      View in: PubMed
    42. Valdameri G, Gauthier C, Terreux R, Kachadourian R, Day BJ, Winnischofer SM, Rocha ME, Frachet V, Ronot X, Di Pietro A, Boumendjel A. Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity. J Med Chem. 2012 Apr 12; 55(7):3193-200. PMID: 22449016.
      View in: PubMed
    43. Kachadourian R, Day BJ, Pugazhenti S, Franklin CC, Genoux-Bastide E, Mahaffey G, Gauthier C, Di Pietro A, Boumendjel A. A synthetic chalcone as a potent inducer of glutathione biosynthesis. J Med Chem. 2012 Feb 09; 55(3):1382-8. PMID: 22239485.
      View in: PubMed
    44. Gould NS, Min E, Martin RJ, Day BJ. CFTR is the primary known apical glutathione transporter involved in cigarette smoke-induced adaptive responses in the lung. Free Radic Biol Med. 2012 Apr 01; 52(7):1201-6. PMID: 22266045.
      View in: PubMed
    45. Liang LP, Waldbaum S, Rowley S, Huang TT, Day BJ, Patel M. Mitochondrial oxidative stress and epilepsy in SOD2 deficient mice: attenuation by a lipophilic metalloporphyrin. Neurobiol Dis. 2012 Mar; 45(3):1068-76. PMID: 22200564.
      View in: PubMed
    46. Gould NS, Min E, Gauthier S, Martin RJ, Day BJ. Lung glutathione adaptive responses to cigarette smoke exposure. Respir Res. 2011 Oct 07; 12:133. PMID: 21982222.
      View in: PubMed
    47. Gould NS, Min E, Day BJ. Macropinocytosis of extracellular glutathione ameliorates tumor necrosis factor a release in activated macrophages. PLoS One. 2011; 6(10):e25704. PMID: 21991336.
      View in: PubMed
    48. Brechbuhl HM, Kachadourian R, Min E, Chan D, Day BJ. Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: the role of glutathione. Toxicol Appl Pharmacol. 2012 Jan 01; 258(1):1-9. PMID: 21856323.
      View in: PubMed
    49. Kachadourian R, Pugazhenthi S, Velmurugan K, Backos DS, Franklin CC, McCord JM, Day BJ. 2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways. Free Radic Biol Med. 2011 Sep 15; 51(6):1146-54. PMID: 21712085.
      View in: PubMed
    50. O'Neill HC, Orlicky DJ, Hendry-Hofer TB, Loader JE, Day BJ, White CW. Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):323-31. PMID: 21642592.
      View in: PubMed
    51. Schroeder SR, White CW, Jones TN, Hendry-Hofer TB, Day BJ, Eaton SS. Impact of SOD-Mimetic Manganoporphyrins on Spin Trapping of Superoxide and Related Artifacts. Appl Magn Reson. 2011 Feb; 40(1):125-134. PMID: 23853422.
      View in: PubMed
    52. McGovern T, Day BJ, White CW, Powell WS, Martin JG. AEOL10150: a novel therapeutic for rescue treatment after toxic gas lung injury. Free Radic Biol Med. 2011 Mar 01; 50(5):602-8. PMID: 21156205.
      View in: PubMed
    53. Tewari-Singh N, Agarwal C, Huang J, Day BJ, White CW, Agarwal R. Efficacy of glutathione in ameliorating sulfur mustard analog-induced toxicity in cultured skin epidermal cells and in SKH-1 mouse skin in vivo. J Pharmacol Exp Ther. 2011 Feb; 336(2):450-9. PMID: 20974699.
      View in: PubMed
    54. Gould NS, Day BJ. Targeting maladaptive glutathione responses in lung disease. Biochem Pharmacol. 2011 Jan 15; 81(2):187-93. PMID: 20951119.
      View in: PubMed
    55. McGovern TK, Powell WS, Day BJ, White CW, Govindaraju K, Karmouty-Quintana H, Lavoie N, Tan JJ, Martin JG. Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma. Respir Res. 2010 Oct 06; 11:138. PMID: 20925946.
      View in: PubMed
    56. Gould NS, Min E, Gauthier S, Chu HW, Martin R, Day BJ. Aging adversely affects the cigarette smoke-induced glutathione adaptive response in the lung. Am J Respir Crit Care Med. 2010 Nov 01; 182(9):1114-22. PMID: 20622027.
      View in: PubMed
    57. Brechbuhl HM, Gould N, Kachadourian R, Riekhof WR, Voelker DR, Day BJ. Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2. J Biol Chem. 2010 May 28; 285(22):16582-7. PMID: 20332504.
      View in: PubMed
    58. O'Neill HC, White CW, Veress LA, Hendry-Hofer TB, Loader JE, Min E, Huang J, Rancourt RC, Day BJ. Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide. Free Radic Biol Med. 2010 May 01; 48(9):1188-96. PMID: 20138141.
      View in: PubMed
    59. Kachadourian R, Brechbuhl HM, Ruiz-Azuara L, Gracia-Mora I, Day BJ. Casiope?na IIgly-induced oxidative stress and mitochondrial dysfunction in human lung cancer A549 and H157 cells. Toxicology. 2010 Feb 09; 268(3):176-83. PMID: 20026372.
      View in: PubMed
    60. Dobis DR, Sawyer RT, Gillespie MM, Newman LS, Maier LA, Day BJ. Sulfasalazine and mesalamine modulate beryllium-specific lymphocyte proliferation and inflammatory cytokine production. Am J Respir Cell Mol Biol. 2010 Oct; 43(4):458-64. PMID: 19901345.
      View in: PubMed
    61. Pal A, Tewari-Singh N, Gu M, Agarwal C, Huang J, Day BJ, White CW, Agarwal R. Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice. Free Radic Biol Med. 2009 Dec 01; 47(11):1640-51. PMID: 19761830.
      View in: PubMed
    62. Kliment CR, Suliman HB, Tobolewski JM, Reynolds CM, Day BJ, Zhu X, McTiernan CF, McGaffin KR, Piantadosi CA, Oury TD. Extracellular superoxide dismutase regulates cardiac function and fibrosis. J Mol Cell Cardiol. 2009 Nov; 47(5):730-42. PMID: 19695260.
      View in: PubMed
    63. Brechbuhl HM, Min E, Kariya C, Frederick B, Raben D, Day BJ. Select cyclopentenone prostaglandins trigger glutathione efflux and the role of ABCG2 transport. Free Radic Biol Med. 2009 Sep 15; 47(6):722-30. PMID: 19520157.
      View in: PubMed
    64. Richens TR, Linderman DJ, Horstmann SA, Lambert C, Xiao YQ, Keith RL, Bo? DM, Morimoto K, Bowler RP, Day BJ, Janssen WJ, Henson PM, Vandivier RW. Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA. Am J Respir Crit Care Med. 2009 Jun 01; 179(11):1011-21. PMID: 19264974.
      View in: PubMed
    65. Gould NS, White CW, Day BJ. A role for mitochondrial oxidative stress in sulfur mustard analog 2-chloroethyl ethyl sulfide-induced lung cell injury and antioxidant protection. J Pharmacol Exp Ther. 2009 Mar; 328(3):732-9. PMID: 19064720.
      View in: PubMed
    66. Day BJ. Catalase and glutathione peroxidase mimics. Biochem Pharmacol. 2009 Feb 01; 77(3):285-96. PMID: 18948086.
      View in: PubMed
    67. Kariya C, Chu HW, Huang J, Leitner H, Martin RJ, Day BJ. Mycoplasma pneumoniae infection and environmental tobacco smoke inhibit lung glutathione adaptive responses and increase oxidative stress. Infect Immun. 2008 Oct; 76(10):4455-62. PMID: 18644874.
      View in: PubMed
    68. Day BJ. Antioxidants as potential therapeutics for lung fibrosis. Antioxid Redox Signal. 2008 Feb; 10(2):355-70. PMID: 17999627.
      View in: PubMed
    69. Dobis DR, Sawyer RT, Gillespie MM, Huang J, Newman LS, Maier LA, Day BJ. Modulation of lymphocyte proliferation by antioxidants in chronic beryllium disease. Am J Respir Crit Care Med. 2008 May 01; 177(9):1002-11. PMID: 18218990.
      View in: PubMed
    70. Castello PR, Drechsel DA, Day BJ, Patel M. Inhibition of mitochondrial hydrogen peroxide production by lipophilic metalloporphyrins. J Pharmacol Exp Ther. 2008 Mar; 324(3):970-6. PMID: 18063723.
      View in: PubMed
    71. Kachadourian R, Leitner HM, Day BJ. Selected flavonoids potentiate the toxicity of cisplatin in human lung adenocarcinoma cells: a role for glutathione depletion. Int J Oncol. 2007 Jul; 31(1):161-8. PMID: 17549417.
      View in: PubMed
    72. Lassen N, Bateman JB, Estey T, Kuszak JR, Nees DW, Piatigorsky J, Duester G, Day BJ, Huang J, Hines LM, Vasiliou V. Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(-/-)/Aldh1a1(-/-) knock-out mice. J Biol Chem. 2007 Aug 31; 282(35):25668-76. PMID: 17567582.
      View in: PubMed
    73. Leitner HM, Kachadourian R, Day BJ. Harnessing drug resistance: using ABC transporter proteins to target cancer cells. Biochem Pharmacol. 2007 Dec 15; 74(12):1677-85. PMID: 17585883.
      View in: PubMed
    74. Liang LP, Huang J, Fulton R, Day BJ, Patel M. An orally active catalytic metalloporphyrin protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in vivo. J Neurosci. 2007 Apr 18; 27(16):4326-33. PMID: 17442816.
      View in: PubMed
    75. Tong JJ, Schriner SE, McCleary D, Day BJ, Wallace DC. Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. Nat Genet. 2007 Apr; 39(4):476-85. PMID: 17369827.
      View in: PubMed
    76. Kariya C, Leitner H, Min E, van Heeckeren C, van Heeckeren A, Day BJ. A role for CFTR in the elevation of glutathione levels in the lung by oral glutathione administration. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1590-7. PMID: 17369290.
      View in: PubMed
    77. Rabbani ZN, Batinic-Haberle I, Anscher MS, Huang J, Day BJ, Alexander E, Dewhirst MW, Vujaskovic Z. Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. Int J Radiat Oncol Biol Phys. 2007 Feb 01; 67(2):573-80. PMID: 17236973.
      View in: PubMed
    78. Wu TJ, Khoo NH, Zhou F, Day BJ, Parks DA. Decreased hepatic ischemia-reperfusion injury by manganese-porphyrin complexes. Free Radic Res. 2007 Feb; 41(2):127-34. PMID: 17364938.
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    79. Lassen N, Pappa A, Black WJ, Jester JV, Day BJ, Min E, Vasiliou V. Antioxidant function of corneal ALDH3A1 in cultured stromal fibroblasts. Free Radic Biol Med. 2006 Nov 01; 41(9):1459-69. PMID: 17023273.
      View in: PubMed
    80. Velsor LW, Kariya C, Kachadourian R, Day BJ. Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice. Am J Respir Cell Mol Biol. 2006 Nov; 35(5):579-86. PMID: 16763223.
      View in: PubMed
    81. Kachadourian R, Day BJ. Flavonoid-induced glutathione depletion: potential implications for cancer treatment. Free Radic Biol Med. 2006 Jul 01; 41(1):65-76. PMID: 16781454.
      View in: PubMed
    82. Martin RJ, Wexler RB, Day BJ, Harbeck RJ, Pinkerton KE, Chu HW. Interaction between cigarette smoke and mycoplasma infection: a murine model. COPD. 2006 Mar; 3(1):3-8. PMID: 17175659.
      View in: PubMed
    83. Lewis W, Day BJ, Kohler JJ, Hosseini SH, Chan SS, Green EC, Haase CP, Keebaugh ES, Long R, Ludaway T, Russ R, Steltzer J, Tioleco N, Santoianni R, Copeland WC. Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma. Lab Invest. 2007 Apr; 87(4):326-35. PMID: 17310215.
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    84. Sawyer RT, Dobis DR, Goldstein M, Velsor L, Maier LA, Fontenot AP, Silveira L, Newman LS, Day BJ. Beryllium-stimulated reactive oxygen species and macrophage apoptosis. Free Radic Biol Med. 2005 Apr 01; 38(7):928-37. PMID: 15749389.
      View in: PubMed
    85. Day BJ, Kariya C. A novel class of cytochrome P450 reductase redox cyclers: cationic manganoporphyrins. Toxicol Sci. 2005 May; 85(1):713-9. PMID: 15703263.
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    86. Day BJ. Glutathione: a radical treatment for cystic fibrosis lung disease? Chest. 2005 Jan; 127(1):12-4. PMID: 15653956.
      View in: PubMed
    87. Velsor LW, Kovacevic M, Goldstein M, Leitner HM, Lewis W, Day BJ. Mitochondrial oxidative stress in human hepatoma cells exposed to stavudine. Toxicol Appl Pharmacol. 2004 Aug 15; 199(1):10-9. PMID: 15289086.
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    88. Sawyer RT, Day BJ, Fadok VA, Chiarappa-Zucca M, Maier LA, Fontenot AP, Silveira L, Newman LS. Beryllium-ferritin: lymphocyte proliferation and macrophage apoptosis in chronic beryllium disease. Am J Respir Cell Mol Biol. 2004 Oct; 31(4):470-7. PMID: 15256386.
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    89. Day BJ. Catalytic antioxidants: a radical approach to new therapeutics. Drug Discov Today. 2004 Jul 01; 9(13):557-66. PMID: 15203091.
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    90. Day BJ, van Heeckeren AM, Min E, Velsor LW. Role for cystic fibrosis transmembrane conductance regulator protein in a glutathione response to bronchopulmonary pseudomonas infection. Infect Immun. 2004 Apr; 72(4):2045-51. PMID: 15039325.
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    91. Day BJ, Lewis W. Oxidative stress in NRTI-induced toxicity: evidence from clinical experience and experiments in vitro and in vivo. Cardiovasc Toxicol. 2004; 4(3):207-16. PMID: 15470269.
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    92. Kachadourian R, Johnson CA, Min E, Spasojevic I, Day BJ. Flavin-dependent antioxidant properties of a new series of meso-N,N'-dialkyl-imidazolium substituted manganese(III) porphyrins. Biochem Pharmacol. 2004 Jan 01; 67(1):77-85. PMID: 14667930.
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    93. Lewis W, Day BJ, Copeland WC. Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective. Nat Rev Drug Discov. 2003 Oct; 2(10):812-22. PMID: 14526384.
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    94. Bowler RP, Velsor LW, Duda B, Chan ED, Abraham E, Ware LB, Matthay MA, Day BJ. Pulmonary edema fluid antioxidants are depressed in acute lung injury. Crit Care Med. 2003 Sep; 31(9):2309-15. PMID: 14501961.
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    95. Trova MP, Gauuan PJ, Pechulis AD, Bubb SM, Bocckino SB, Crapo JD, Day BJ. Superoxide dismutase mimetics. Part 2: synthesis and structure-activity relationship of glyoxylate- and glyoxamide-derived metalloporphyrins. Bioorg Med Chem. 2003 Jul 03; 11(13):2695-707. PMID: 12788343.
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    96. Kachadourian R, Flaherty MM, Crumbliss AL, Patel M, Day BJ. Synthesis and in vitro antioxidant properties of manganese(III) beta-octabromo-meso-tetrakis(4-carboxyphenyl)porphyrin. J Inorg Biochem. 2003 Jul 01; 95(4):240-8. PMID: 12818794.
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    97. Wang W, Jittikanont S, Falk SA, Li P, Feng L, Gengaro PE, Poole BD, Bowler RP, Day BJ, Crapo JD, Schrier RW. Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure. Am J Physiol Renal Physiol. 2003 Mar; 284(3):F532-7. PMID: 12556364.
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    98. Chang LY, Subramaniam M, Yoder BA, Day BJ, Ellison MC, Sunday ME, Crapo JD. A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2003 Jan 01; 167(1):57-64. PMID: 12502477.
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    99. Gardai SJ, Hoontrakoon R, Goddard CD, Day BJ, Chang LY, Henson PM, Bratton DL. Oxidant-mediated mitochondrial injury in eosinophil apoptosis: enhancement by glucocorticoids and inhibition by granulocyte-macrophage colony-stimulating factor. J Immunol. 2003 Jan 01; 170(1):556-66. PMID: 12496443.
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    100. Ross AD, Sheng H, Warner DS, Piantadosi CA, Batinic-Haberle I, Day BJ, Crapo JD. Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity. Free Radic Biol Med. 2002 Dec 15; 33(12):1657-69. PMID: 12488134.
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    101. Gauuan PJ, Trova MP, Gregor-Boros L, Bocckino SB, Crapo JD, Day BJ. Superoxide dismutase mimetics: synthesis and structure-activity relationship study of MnTBAP analogues. Bioorg Med Chem. 2002 Sep; 10(9):3013-21. PMID: 12110324.
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    102. Graziewicz MA, Day BJ, Copeland WC. The mitochondrial DNA polymerase as a target of oxidative damage. Nucleic Acids Res. 2002 Jul 01; 30(13):2817-24. PMID: 12087165.
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    103. Thibodeau PA, Kachadourian R, Lemay R, Bisson M, Day BJ, Paquette B. In vitro pro- and antioxidant properties of estrogens. J Steroid Biochem Mol Biol. 2002 Jul; 81(3):227-36. PMID: 12163134.
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    104. Kachadourian R, Menzeleev R, Agha B, Bocckino SB, Day BJ. High-performance liquid chromatography with spectrophotometric and electrochemical detection of a series of manganese(III) cationic porphyrins. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Feb 05; 767(1):61-7. PMID: 11863296.
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    105. Piganelli JD, Flores SC, Cruz C, Koepp J, Batinic-Haberle I, Crapo J, Day B, Kachadourian R, Young R, Bradley B, Haskins K. A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes. 2002 Feb; 51(2):347-55. PMID: 11812741.
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    106. Gow AJ, Chen Q, Hess DT, Day BJ, Ischiropoulos H, Stamler JS. Basal and stimulated protein S-nitrosylation in multiple cell types and tissues. J Biol Chem. 2002 Mar 22; 277(12):9637-40. PMID: 11796706.
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