Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Manisha N Patel

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-DOPS General Operations
Phone303/724-3604

    Collapse Research 
    Collapse research activities and funding
    R01HD102071     (PATEL, MANISHA N)Jun 1, 2020 - May 31, 2025
    NIH
    Gluconeogenic control of Dravet Syndrome
    Role: Principal Investigator

    R01NS086423     (PATEL, MANISHA N)Sep 30, 2013 - Jun 30, 2024
    NIH
    Redox Control of Seizure-Induced Neuroinflammation.
    Role: Principal Investigator

    U01NS083422     (PATEL, MANISHA N)Sep 15, 2013 - Aug 31, 2020
    NIH
    Neuroprotective effects of AEOL 10150 against organophosphate toxicity
    Role: Principal Investigator

    R21NS072099     (PATEL, MANISHA N)Sep 30, 2011 - Aug 31, 2015
    NIH
    Evaluation of Neuroprotective Effects of AEOL10150 against Chemical Threat Agents
    Role: Principal Investigator

    R21NS053548     (PATEL, MANISHA N)May 25, 2006 - Apr 30, 2009
    NIH
    Two-step therapeutic screen for mitochondrial epilepsies
    Role: Principal Investigator

    R01NS045748     (PATEL, MANISHA N)Apr 1, 2003 - Nov 30, 2015
    NIH
    Mitochondrial mechanisms of redox cycling agents
    Role: Principal Investigator

    R37NS039587     (PATEL, MANISHA N)Dec 1, 1999 - Jun 30, 2026
    NIH
    Mitochondrial Mechanisms of Astrogliosis in Epilesy
    Role: Principal Investigator

    R01NS039587     (PATEL, MANISHA N)Dec 1, 1999 - Jun 30, 2021
    NIH
    Mitochondrial Sirtuin-3 dysregulation in epileptogenesis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Adair L, Han R, Fulton R, Figueroa A, Patel M. A multielectrode array reveals therapeutic potential of translocator protein ligands in a zebrafish model of Dravet syndrome. J Pharmacol Exp Ther. 2025 Jul; 392(7):103614. PMID: 40561753.
      View in: PubMed
    2. Ponnaiah M, Ganesan S, Bhatnagar T, Thulasingam M, Majella MG, Karuppiah M, Rizwan SA, Alexander A, Sarkar S, Kar SS, Kadhiravan T, Bhatnagar A, Kumar S P, Pillai VM, Nair PP, Dhodapkar R, Ch Toi P, Singh R, Kasthuri N, Kumar GCP, Jaisankar S, Saini V, Kankaria A, Raj A, Goyal A, Sharma V, Khichar S, Soni K, Garg MK, Selvaraj K, B H S, Bhavana K, Bharti B, Singh CM, Chaudhary N, R V, K G, Palaninathan K, Dube S, Singh Saxena R, Gupta N, Rathinavel A, Priya S, Bellad SA, Kavi A, Harugop AS, Pujary K, Ballala K, Mallya SD, Prasad HM, Ravi D, Balaji NK, Hegde R, Mishra N, Ray S, Karthikeyan S, Ramalingam S, Murali A, Vaidya S, Samadhiya M, Bhojani D, Lakshmanan S, Singh SRB, Pillai N, Deepthi P, Banumathi K, Sumathi V, Ramesh D, Nissar SP, Sheikh KM, Patel MN, Shristava V, Kumar SS, Shantaraman K, Pandian RD, Murhekar M, Aggarwal R. Correction: Hyperglycemia and steroid use increase the risk of rhino-orbito-cerebral mucormycosis regardless of COVID-19 hospitalization: Case-control study, India. PLoS One. 2025; 20(4):e0322153. PMID: 40184380.
      View in: PubMed
    3. Figueroa AG, Fulton RE, Banerji R, Knupp KG, Patel MN. Mitochondrial respiration defects in lymphoblast cell lines from patients with Dravet syndrome. Epilepsia. 2025 Jul; 66(7):2507-2520. PMID: 40119852.
      View in: PubMed
    4. Liang LP, Sri Hari A, Day BJ, Patel M. Pharmacological elevation of glutathione inhibits status epilepticus-induced neuroinflammation and oxidative injury. Redox Biol. 2024 07; 73:103168. PMID: 38714094.
      View in: PubMed
    5. Liang LP, Pearson-Smith JN, Day BJ, Patel M. Novel Catalytic Antioxidant Formulation Decreases Oxidative Stress, Neuroinflammation and Cognitive Dysfunction in a Model of Nerve Agent Intoxication. J Pharmacol Exp Ther. 2024 01 17; 388(2):358-366. PMID: 37652711.
      View in: PubMed
    6. Patel M. Treatment of drug-resistant epilepsy: diet or pill? Lancet Neurol. 2023 12; 22(12):1088-1089. PMID: 37977699.
      View in: PubMed
    7. Sri Hari A, Banerji R, Liang LP, Fulton RE, Huynh CQ, Fabisiak T, McElroy PB, Roede JR, Patel M. Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability. Redox Biol. 2023 11; 67:102895. PMID: 37769522.
      View in: PubMed
    8. Temple MJ, Abruzzo TA, Muñoz FG, Amaral JG, Bogan KA, Gibson C, Patel PA, Toh LM, Zhang J, Mubarak WM, Connolly BL, Mitchell SE, Barnacle AM, Cahill AM, Braswell LE, Marshalleck FE, Patel MN, Feola GP, Chaudry GA, Chennapragada SM, Josephs SC, Annam A, Goman SK. Fostering research in pediatric interventional radiology: needs assessment and suggestions for support. Pediatr Radiol. 2023 Oct; 53(11):2245-2252. PMID: 37568041.
      View in: PubMed
    9. Pearson-Smith JN, Fulton R, Huynh CQ, Figueroa AG, Huynh GB, Liang LP, Gano LB, Michel CR, Reisdorph N, Reisdorph R, Fritz KS, Verdin E, Patel M. Neuronal SIRT3 Deletion Predisposes to Female-Specific Alterations in Cellular Metabolism, Memory, and Network Excitability. J Neurosci. 2023 03 08; 43(10):1845-1857. PMID: 36759193.
      View in: PubMed
    10. Ponnaiah M, Ganesan S, Bhatnagar T, Thulasingam M, Majella MG, Karuppiah M, Rizwan SA, Alexander A, Sarkar S, Kar SS, Kadhiravan T, Bhatnagar A, S PK, Pillai VM, Nair PP, Dhodapkar R, Ch Toi P, Singh R, Kasthuri N, Kumar GCP, Jaisankar S, Saini V, Kankaria A, Raj A, Goyal A, Sharma V, Khichar S, Soni K, Garg MK, Selvaraj K, B H S, Bhavana K, Bharti B, Singh CM, Chaudhary N, R V, K G, Palaninathan K, Dube S, Saxena RS, Gupta N, Rathinavel A, Priya S, Bellad SA, Kavi A, Harugop AS, Pujary K, Ballala K, Mallya SD, Prasad HM, Ravi D, Balaji NK, Hegde R, Mishra N, Ray S, Karthikeyan S, Ramalingam S, Murali A, Vaidya S, Samadhiya M, Bhojani D, Lakshmanan S, Singh SRB, Pillai N, Deepthi P, Banumathi K, Sumathi V, Ramesh D, Nissar SP, Sheikh KM, Patel MN, Shristava V, Kumar SS, Shantaraman K, Pandian RD, Murhekar M, Aggarwal R. Hyperglycemia and steroid use increase the risk of rhino-orbito-cerebral mucormycosis regardless of COVID-19 hospitalization: Case-control study, India. PLoS One. 2022; 17(8):e0272042. PMID: 35939442.
      View in: PubMed
    11. Fulton RE, Pearson-Smith JN, Huynh CQ, Fabisiak T, Liang LP, Aivazidis S, High BA, Buscaglia G, Corrigan T, Valdez R, Shimizu T, Patel MN. Neuron-specific mitochondrial oxidative stress results in epilepsy, glucose dysregulation and a striking astrocyte response. Neurobiol Dis. 2021 10; 158:105470. PMID: 34371143.
      View in: PubMed
    12. Liang LP, Fulton R, Bradshaw-Pierce EL, Pearson-Smith J, Day BJ, Patel M. Optimization of Lipophilic Metalloporphyrins Modifies Disease Outcomes in a Rat Model of Parkinsonism. J Pharmacol Exp Ther. 2021 04; 377(1):1-10. PMID: 33500265.
      View in: PubMed
    13. Shah R, Soni T, Shah U, Suhagia BN, Patel MN, Patel T, Gabr GA, Gorain B, Kesharwani P. Formulation development and characterization of lumefantrine nanosuspension for enhanced antimalarial activity. J Biomater Sci Polym Ed. 2021 05; 32(7):833-857. PMID: 33380264.
      View in: PubMed
    14. Patel MN. Metalloporphyrins improve the survival of Sod2-deficient neurons. Aging Cell. 2003 08; 2(4):219-22. PMID: 12934715.
      View in: PubMed
    15. Patel MN. Oxidative stress, mitochondrial dysfunction, and epilepsy. Free Radic Res. 2002 Nov; 36(11):1139-46. PMID: 12592665.
      View in: PubMed
    16. Kachadourian R, Liochev SI, Cabelli DE, Patel MN, Fridovich I, Day BJ. 2-methoxyestradiol does not inhibit superoxide dismutase. Arch Biochem Biophys. 2001 Aug 15; 392(2):349-53. PMID: 11488612.
      View in: PubMed
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