 Ribonucleoprotein, U1 Small Nuclear
"Ribonucleoprotein, U1 Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U1 snRNP along with other small nuclear ribonucleoproteins (U2, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction.
| Descriptor ID |
D017412
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| MeSH Number(s) |
D12.776.157.725.500.875.600 D12.776.157.725.829.313 D12.776.664.962.500.875.600 D12.776.664.962.829.313
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| Concept/Terms |
Ribonucleoprotein, U1 Small Nuclear- Ribonucleoprotein, U1 Small Nuclear
- U1 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, Small, U1
- Small Nuclear Ribonucleoproteins, U1
- U1 snRNP
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Below are MeSH descriptors whose meaning is more general than "Ribonucleoprotein, U1 Small Nuclear".
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This graph shows the total number of publications written about "Ribonucleoprotein, U1 Small Nuclear" by people in this website by year, and whether "Ribonucleoprotein, U1 Small Nuclear" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2008 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ribonucleoprotein, U1 Small Nuclear" by people in Profiles.
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Shenasa H, Movassat M, Forouzmand E, Hertel KJ. Allosteric regulation of U1 snRNP by splicing regulatory proteins controls spliceosomal assembly. RNA. 2020 10; 26(10):1389-1399.
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De Bortoli F, Neumann A, Kotte A, Timmermann B, Sch?ler T, Wahl MC, Loll B, Heyd F. Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39. Nucleic Acids Res. 2019 06 20; 47(11):5867-5879.
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Li X, Liu S, Jiang J, Zhang L, Espinosa S, Hill RC, Hansen KC, Zhou ZH, Zhao R. CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing. Nat Commun. 2017 10 19; 8(1):1035.
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Wang Q, Taliaferro JM, Klibaite U, Hilgers V, Shaevitz JW, Rio DC. The PSI-U1 snRNP interaction regulates male mating behavior in Drosophila. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):5269-74.
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Seth P, Miller HB, Lasda EL, Pearson JL, Garcia-Blanco MA. Identification of an intronic splicing enhancer essential for the inclusion of FGFR2 exon IIIc. J Biol Chem. 2008 Apr 11; 283(15):10058-67.
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Saldi T, Wilusz C, MacMorris M, Blumenthal T. Functional redundancy of worm spliceosomal proteins U1A and U2B''. Proc Natl Acad Sci U S A. 2007 Jun 05; 104(23):9753-7.
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