 Ribonucleoprotein, U2 Small Nuclear
"Ribonucleoprotein, U2 Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U2 snRNP along with other small nuclear ribonucleoproteins (U1, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U2 snRNA forms base pairs with conserved sequence motifs at the branch point, which associates with a heat- and RNAase-sensitive factor in an early step of splicing.
| Descriptor ID |
D017413
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| MeSH Number(s) |
D12.776.157.725.500.875.605 D12.776.157.725.829.344 D12.776.664.962.500.875.605 D12.776.664.962.829.344
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| Concept/Terms |
Ribonucleoprotein, U2 Small Nuclear- Ribonucleoprotein, U2 Small Nuclear
- U2 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, Small, U2
- Small Nuclear Ribonucleoproteins, U2
- U2 snRNP
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Below are MeSH descriptors whose meaning is more general than "Ribonucleoprotein, U2 Small Nuclear".
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This graph shows the total number of publications written about "Ribonucleoprotein, U2 Small Nuclear" by people in this website by year, and whether "Ribonucleoprotein, U2 Small Nuclear" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ribonucleoprotein, U2 Small Nuclear" by people in Profiles.
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Schreiber CA, Sakuma T, Izumiya Y, Holditch SJ, Hickey RD, Bressin RK, Basu U, Koide K, Asokan A, Ikeda Y. An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses. PLoS Pathog. 2015 Aug; 11(8):e1005082.
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O'Connor BP, Danhorn T, De Arras L, Flatley BR, Marcus RA, Farias-Hesson E, Leach SM, Alper S. Regulation of toll-like receptor signaling by the SF3a mRNA splicing complex. PLoS Genet. 2015 Feb; 11(2):e1004932.
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De Arras L, Alper S. Limiting of the innate immune response by SF3A-dependent control of MyD88 alternative mRNA splicing. PLoS Genet. 2013 Oct; 9(10):e1003855.
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Saldi T, Wilusz C, MacMorris M, Blumenthal T. Functional redundancy of worm spliceosomal proteins U1A and U2B''. Proc Natl Acad Sci U S A. 2007 Jun 05; 104(23):9753-7.
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