 Ribonucleoprotein, U4-U6 Small Nuclear
"Ribonucleoprotein, U4-U6 Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U4-U6 snRNP along with the U5 snRNP preassemble into a single 25S particle that binds to the U1 and U2 snRNPs and the substrate to form mature SPLICEOSOMES. There is also evidence for the existence of individual U4 or U6 snRNPs in addition to their organization as a U4-U6 snRNP.
| Descriptor ID |
D017414
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| MeSH Number(s) |
D12.776.157.725.500.875.615 D12.776.664.962.500.875.615
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| Concept/Terms |
Ribonucleoprotein, U4-U6 Small Nuclear- Ribonucleoprotein, U4-U6 Small Nuclear
- Ribonucleoprotein, U4 U6 Small Nuclear
- U4-U6 Small Nuclear Ribonucleoproteins
- U4 U6 Small Nuclear Ribonucleoproteins
- Small Nuclear Ribonucleoproteins, U4-U6
- Small Nuclear Ribonucleoproteins, U4 U6
- U4-U6 snRNP
- Ribonucleoproteins, Small, U4-U6
U6 snRNP- U6 snRNP
- U6 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, U6 Small Nuclear
- Small Nuclear Ribonucleoproteins, U6
U4 snRNP- U4 snRNP
- U4 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, U4 Small Nuclear
- Small Nuclear Ribonucleoproteins, U4
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Below are MeSH descriptors whose meaning is more general than "Ribonucleoprotein, U4-U6 Small Nuclear".
Below are MeSH descriptors whose meaning is more specific than "Ribonucleoprotein, U4-U6 Small Nuclear".
This graph shows the total number of publications written about "Ribonucleoprotein, U4-U6 Small Nuclear" by people in this website by year, and whether "Ribonucleoprotein, U4-U6 Small Nuclear" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2015 | 2 | 0 | 2 | | 2017 | 2 | 0 | 2 |
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Below are the most recent publications written about "Ribonucleoprotein, U4-U6 Small Nuclear" by people in Profiles.
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Liu S, Li X, Zhang L, Jiang J, Hill RC, Cui Y, Hansen KC, Zhou ZH, Zhao R. Structure of the yeast spliceosomal postcatalytic P complex. Science. 2017 12 08; 358(6368):1278-1283.
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Rajiv C, Jackson SR, Cocklin S, Eisenmesser EZ, Davis TL. The spliceosomal proteins PPIH and PRPF4 exhibit bi-partite binding. Biochem J. 2017 10 25; 474(21):3689-3704.
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Hardin JW, Warnasooriya C, Kondo Y, Nagai K, Rueda D. Assembly and dynamics of the U4/U6 di-snRNP by single-molecule FRET. Nucleic Acids Res. 2015 Dec 15; 43(22):10963-74.
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Zhang L, Li X, Hill RC, Qiu Y, Zhang W, Hansen KC, Zhao R. Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding. Nucleic Acids Res. 2015 Mar 31; 43(6):3286-97.
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Li X, Zhang W, Xu T, Ramsey J, Zhang L, Hill R, Hansen KC, Hesselberth JR, Zhao R. Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly. Nucleic Acids Res. 2013 Apr 01; 41(6):3805-18.
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Zhang L, Xu T, Maeder C, Bud LO, Shanks J, Nix J, Guthrie C, Pleiss JA, Zhao R. Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2. Nat Struct Mol Biol. 2009 Jul; 16(7):731-9.
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Yang K, Zhang L, Xu T, Heroux A, Zhao R. Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):13817-22.
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Decker CJ, Teixeira D, Parker R. Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae. J Cell Biol. 2007 Nov 05; 179(3):437-49.
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