 Antigen Presentation
"Antigen Presentation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)
| Descriptor ID |
D017951
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| MeSH Number(s) |
G12.119 G12.450.050.400.070
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Antigen Presentation".
Below are MeSH descriptors whose meaning is more specific than "Antigen Presentation".
This graph shows the total number of publications written about "Antigen Presentation" by people in this website by year, and whether "Antigen Presentation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 1 | 3 | | 1997 | 1 | 0 | 1 | | 1998 | 5 | 1 | 6 | | 1999 | 1 | 3 | 4 | | 2000 | 1 | 2 | 3 | | 2001 | 7 | 3 | 10 | | 2002 | 3 | 2 | 5 | | 2003 | 3 | 1 | 4 | | 2004 | 1 | 3 | 4 | | 2005 | 4 | 5 | 9 | | 2006 | 1 | 4 | 5 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 5 | 6 | | 2009 | 2 | 4 | 6 | | 2010 | 1 | 2 | 3 | | 2011 | 5 | 5 | 10 | | 2012 | 2 | 2 | 4 | | 2013 | 2 | 4 | 6 | | 2014 | 1 | 2 | 3 | | 2015 | 2 | 3 | 5 | | 2016 | 4 | 3 | 7 | | 2017 | 4 | 3 | 7 | | 2018 | 4 | 4 | 8 | | 2019 | 0 | 4 | 4 | | 2020 | 0 | 7 | 7 | | 2021 | 0 | 5 | 5 | | 2022 | 1 | 1 | 2 | | 2023 | 0 | 2 | 2 | | 2024 | 2 | 2 | 4 | | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Antigen Presentation" by people in Profiles.
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van der Heide V, Laghlali G, Davenport B, Cubitt B, Roudko V, Choo D, Jhun K, Humblin E, Vaidya A, Angeliadis K, Dawson T, Furtado G, Kamphorst AO, Schotsaert M, Ahmed R, de la Torre JC, Homann D. Prolonged but finite antigen presentation promotes reversible defects of "helpless" memory CD8+ T cells. Immunity. 2025 Jul 08; 58(7):1742-1761.e14.
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Peddaboina C, Iannucci J, Tobin RP, Shapiro LA, Newell Rogers MK. Autophagy Differentially Influences Toll-like Receptor 9 and B Cell-Receptor-Mediated B Cell Expansion, Expression of Major Histocompatibility Class II Proteins, and Antigenic Peptide Presentation. Int J Mol Sci. 2025 Jun 24; 26(13).
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Waibl Polania J, Hoyt-Miggelbrink A, Tomaszewski WH, Wachsmuth LP, Lorrey SJ, Wilkinson DS, Lerner E, Woroniecka K, Finlay JB, Ayasoufi K, Fecci PE. Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion. Immunity. 2025 Jan 14; 58(1):232-246.e6.
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Bullock CB, Wang L, Ware BC, Wagoner N, Ohara RA, Liu T-T, Desai P, Peters B, Murphy KM, Handley SA, Morrison TE, Diamond MS. Type I interferon signaling in dendritic cells limits direct antigen presentation and CD8+ T cell responses against an arthritogenic alphavirus. mBio. 2024 Dec 11; 15(12):e0293024.
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Guak H, Weiland M, Ark AV, Zhai L, Lau K, Corrado M, Davidson P, Asiedu E, Mabvakure B, Compton S, DeCamp L, Scullion CA, Jones RG, Nowinski SM, Krawczyk CM. Transcriptional programming mediated by the histone demethylase KDM5C regulates dendritic cell population heterogeneity and function. Cell Rep. 2024 08 27; 43(8):114506.
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Ware BC, Parks MG, da Silva MOL, Morrison TE. Chikungunya virus infection disrupts MHC-I antigen presentation via nonstructural protein 2. PLoS Pathog. 2024 Mar; 20(3):e1011794.
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Mangalhara KC, Varanasi SK, Johnson MA, Burns MJ, Rojas GR, Esparza Moltó PB, Sainz AG, Tadepalle N, Abbott KL, Mendiratta G, Chen D, Farsakoglu Y, Kunchok T, Hoffmann FA, Parisi B, Rincon M, Vander Heiden MG, Bosenberg M, Hargreaves DC, Kaech SM, Shadel GS. Manipulating mitochondrial electron flow enhances tumor immunogenicity. Science. 2023 09 22; 381(6664):1316-1323.
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Corey Z, Schechter E, Nemenoff RA. Un-FASN-ing cancer's seat belt: Linking lipid metabolism and antigen presentation. Cell Chem Biol. 2023 09 21; 30(9):1004-1006.
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Liu H, Lin J, Zhou W, Moses R, Dai Z, Kossenkov AV, Drapkin R, Bitler BG, Karakashev S, Zhang R. KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer. Cancer Immunol Res. 2022 08 03; 10(8):1028-1038.
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Schriek P, Ching AC, Moily NS, Moffat J, Beattie L, Steiner TM, Hosking LM, Thurman JM, Holers VM, Ishido S, Lahoud MH, Caminschi I, Heath WR, Mintern JD, Villadangos JA. Marginal zone B cells acquire dendritic cell functions by trogocytosis. Science. 2022 02 11; 375(6581):eabf7470.
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