 Cytotoxicity, Immunologic
"Cytotoxicity, Immunologic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
| Descriptor ID |
D003602
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| MeSH Number(s) |
G12.287
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cytotoxicity, Immunologic".
Below are MeSH descriptors whose meaning is more specific than "Cytotoxicity, Immunologic".
This graph shows the total number of publications written about "Cytotoxicity, Immunologic" by people in this website by year, and whether "Cytotoxicity, Immunologic" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 2 | 3 | | 1996 | 3 | 1 | 4 | | 1997 | 0 | 2 | 2 | | 1998 | 2 | 3 | 5 | | 1999 | 0 | 3 | 3 | | 2000 | 3 | 3 | 6 | | 2001 | 2 | 5 | 7 | | 2002 | 1 | 2 | 3 | | 2003 | 0 | 5 | 5 | | 2004 | 0 | 5 | 5 | | 2005 | 1 | 3 | 4 | | 2006 | 0 | 5 | 5 | | 2007 | 0 | 5 | 5 | | 2008 | 0 | 3 | 3 | | 2009 | 2 | 4 | 6 | | 2010 | 0 | 6 | 6 | | 2011 | 0 | 2 | 2 | | 2012 | 1 | 2 | 3 | | 2013 | 1 | 3 | 4 | | 2014 | 1 | 4 | 5 | | 2015 | 2 | 2 | 4 | | 2016 | 2 | 5 | 7 | | 2017 | 0 | 1 | 1 | | 2018 | 1 | 4 | 5 | | 2019 | 0 | 6 | 6 | | 2020 | 1 | 2 | 3 | | 2021 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 | | 2024 | 1 | 2 | 3 | | 2025 | 1 | 1 | 2 |
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Below are the most recent publications written about "Cytotoxicity, Immunologic" by people in Profiles.
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Kuznetsova V, Krishnan V, Costa A, Ren X, Ricketts TD, Patel SB, Connelly AN, Goel P, Knapp JP, Franceski AM, Luca F, Lobo de Figueiredo-Pontes L, Bhatia R, Prabhakar S, Ong ST, Welner RS. Chronic inflammation deters natural killer cell fitness and cytotoxicity in myeloid leukemia. Blood Adv. 2025 Feb 25; 9(4):759-773.
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DeGolier KR, Danis E, D'Antonio M, Cimons J, Yarnell M, Kedl RM, Kohler ME, Scott-Browne JP, Fry TJ. Antigen experience history directs distinct functional states of CD8+ CAR T cells during the antileukemia response. Nat Immunol. 2025 Jan; 26(1):68-81.
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Escoto A, Hecksel R, Parkinson C, Crane S, Atwell B, King S, Ortiz Chavez D, Jannuzi A, Sands B, Bitler BG, Fehniger TA, Paek AL, Padi M, Schroeder J. Nuclear EGFR in breast cancer suppresses NK cell recruitment and cytotoxicity. Oncogene. 2025 Feb; 44(5):288-295.
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Hay ZLZ, Kim DD, Cimons JM, Knapp JR, Kohler ME, Quansah M, Z??iga TM, Camp FA, Fujita M, Wang XJ, O'Connor BP, Slansky JE. Granzyme F: Exhaustion Marker and Modulator of Chimeric Antigen Receptor T Cell-Mediated Cytotoxicity. J Immunol. 2024 Apr 15; 212(8):1381-1391.
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Yandamuri SS, Filipek B, Lele N, Cohen I, Bennett JL, Nowak RJ, Sotirchos ES, Longbrake EE, Mace EM, O'Connor KC. A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases. J Immunol. 2024 Mar 01; 212(5):785-800.
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Yandamuri SS, Filipek B, Obaid AH, Lele N, Thurman JM, Makhani N, Nowak RJ, Guo Y, Lucchinetti CF, Flanagan EP, Longbrake EE, O'Connor KC. MOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity. JCI Insight. 2023 06 08; 8(11).
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Isola I, Bras?-Maristany F, Moreno DF, Mena MP, Oliver-Calders A, Par? L, Rodr?guez-Lobato LG, Martin-Antonio B, Cibeira MT, Blad? J, Rosi?ol L, Prat A, Lozano E, Fern?ndez de Larrea C. Gene Expression Analysis of the Bone Marrow Microenvironment Reveals Distinct Immunotypes in Smoldering Multiple Myeloma Associated to Progression to Symptomatic Disease. Front Immunol. 2021; 12:792609.
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Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children. Immunity. 2021 05 11; 54(5):1083-1095.e7.
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Guth A, Monk E, Agarwal R, Bergman BC, Zemski-Berry KA, Minic A, Jordan K, Schlaepfer IR. Targeting Fat Oxidation in Mouse Prostate Cancer Decreases Tumor Growth and Stimulates Anti-Cancer Immunity. Int J Mol Sci. 2020 Dec 18; 21(24).
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Buggert M, Vella LA, Nguyen S, Wu VH, Chen Z, Sekine T, Perez-Potti A, Maldini CR, Manne S, Darko S, Ransier A, Kuri-Cervantes L, Japp AS, Brody IB, Ivarsson MA, Gorin JB, Rivera-Ballesteros O, Hertwig L, Antel JP, Johnson ME, Okoye A, Picker L, Vahedi G, Sparrelid E, Llewellyn-Lacey S, Gostick E, Sandberg JK, Bj?rkstr?m N, Bar-Or A, Dori Y, Naji A, Canaday DH, Laufer TM, Wells AD, Price DA, Frank I, Douek DC, Wherry EJ, Itkin MG, Betts MR. The Identity of Human Tissue-Emigrant CD8+ T Cells. Cell. 2020 12 23; 183(7):1946-1961.e15.
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