 NAV1.1 Voltage-Gated Sodium Channel
"NAV1.1 Voltage-Gated Sodium Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A voltage-gated sodium channel subtype that is predominantly expressed in the CENTRAL NERVOUS SYSTEM. Defects in the SCN1A gene which codes for the alpha subunit of this sodium channel are associated with DRAVET SYNDROME, generalized epilepsy with febrile seizures plus, type 2 (GEFS+2), and familial hemiplegic migraine type 3.
| Descriptor ID |
D062550
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| MeSH Number(s) |
D12.776.157.530.400.875.750.100 D12.776.543.550.450.875.750.100 D12.776.543.585.400.875.750.100 D12.776.631.960.100
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| Concept/Terms |
NAV1.1 Voltage-Gated Sodium Channel- NAV1.1 Voltage-Gated Sodium Channel
- NAV1.1 Voltage Gated Sodium Channel
- Voltage-Gated Sodium Channel Type 1
- Voltage Gated Sodium Channel Type 1
- Type 1 Voltage-Gated Sodium Channel
- Type 1 Voltage Gated Sodium Channel
Voltage-Gated Sodium Channel Type 1 Subunit alpha- Voltage-Gated Sodium Channel Type 1 Subunit alpha
- Voltage Gated Sodium Channel Type 1 Subunit alpha
- Sodium Channel, Voltage-Gated, Type I, alpha Protein
- SCN1A Sodium Channel alpha Subunit
- Voltage-Gated Sodium Channel Type 1 alpha Subunit
- Voltage Gated Sodium Channel Type 1 alpha Subunit
- NAV1.1 alpha Subunit
- alpha Subunit, NAV1.1
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Below are MeSH descriptors whose meaning is more general than "NAV1.1 Voltage-Gated Sodium Channel".
Below are MeSH descriptors whose meaning is more specific than "NAV1.1 Voltage-Gated Sodium Channel".
This graph shows the total number of publications written about "NAV1.1 Voltage-Gated Sodium Channel" by people in this website by year, and whether "NAV1.1 Voltage-Gated Sodium Channel" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2017 | 0 | 3 | 3 | | 2019 | 2 | 1 | 3 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "NAV1.1 Voltage-Gated Sodium Channel" by people in Profiles.
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Perry MS, Scheffer IE, Sullivan J, Brunklaus A, Boronat S, Wheless JW, Laux L, Patel AD, Roberts CM, Dlugos D, Holder D, Knupp KG, Lallas M, Phillips S, Segal E, Smeyers P, Lal D, Wirrell E, Zuberi S, Br?nger T, Wojnaroski M, Maru B, O'Donnell P, Morton M, James E, Vila MC, Huang N, Gofshteyn JS, Rico S. Severe communication delays are independent of seizure burden and persist despite contemporary treatments in SCN1A+ Dravet syndrome: Insights from the ENVISION natural history study. Epilepsia. 2024 Feb; 65(2):322-337.
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Xie Y, Ng NN, Safrina OS, Ramos CM, Ess KC, Schwartz PH, Smith MA, O'Dowd DK. Comparisons of dual isogenic human iPSC pairs identify functional alterations directly caused by an epilepsy associated SCN1A mutation. Neurobiol Dis. 2020 02; 134:104627.
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Deuel L, Collins AE, Maa EH, Barr JP, Kern DS. Dravet syndrome and parkinsonism: A case report investigating the dopaminergic system. Neurology. 2019 09 24; 93(13):595-596.
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Angione K, Eschbach K, Smith G, Joshi C, Demarest S. Genetic testing in a cohort of patients with potential epilepsy with myoclonic-atonic seizures. Epilepsy Res. 2019 02; 150:70-77.
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Carvill GL, Engel KL, Ramamurthy A, Cochran JN, Roovers J, Stamberger H, Lim N, Schneider AL, Hollingsworth G, Holder DH, Regan BM, Lawlor J, Lagae L, Ceulemans B, Bebin EM, Nguyen J, Barsh GS, Weckhuysen S, Meisler M, Berkovic SF, De Jonghe P, Scheffer IE, Myers RM, Cooper GM, Mefford HC. Aberrant Inclusion of a Poison Exon Causes Dravet Syndrome and Related SCN1A-Associated Genetic Epilepsies. Am J Hum Genet. 2018 12 06; 103(6):1022-1029.
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Eschbach K, Scarbro S, Juarez-Colunga E, Allen V, Hsu S, Knupp K. Growth and endocrine function in children with Dravet syndrome. Seizure. 2017 Nov; 52:117-122.
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Knupp KG, Scarbro S, Wilkening G, Juarez-Colunga E, Kempe A, Dempsey A. Parental Perception of Comorbidities in Children With Dravet Syndrome. Pediatr Neurol. 2017 Nov; 76:60-65.
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Griffin A, Hamling KR, Knupp K, Hong S, Lee LP, Baraban SC. Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome. Brain. 2017 03 01; 140(3):669-683.
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Wang W, Atianjoh F, Gauda EB, Yaster M, Li Y, Tao YX. Increased expression of sodium channel subunit Nav1.1 in the injured dorsal root ganglion after peripheral nerve injury. Anat Rec (Hoboken). 2011 Aug; 294(8):1406-11.
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