Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Drew Scott Kern

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-NEUR General Operations
    Other Positions
    TitleDirector-Faculty
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-NEUR General Operations


    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dang NH, Kern DS, Honce JM, Ojemann SG, Tanabe JL. Skull Lesions Following MR-Guided High-Intensity Focused Ultrasound: A Case Series. AJNR Am J Neuroradiol. 2025 Aug 08. PMID: 40780877.
      View in: PubMed
    2. Baumgartner AJ, Hirt L, Amara AW, Kern DS, Thompson JA. Diurnal fluctuations of subthalamic nucleus local field potentials follow naturalistic sleep-wake behavior in Parkinson's disease. Sleep. 2025 Jun 13; 48(6). PMID: 39798074.
      View in: PubMed
    3. Sakai JT, Tanabe J, Battula S, Zipperly M, Mikulich-Gilbertson SK, Kern DS, Thompson JA, Ojemann S, Raymond K, Gerecht PD, Foster K, Abosch A. Corrigendum: Deep brain stimulation for the treatment of substance use disorders: a promising approach requiring caution. Front Psychiatry. 2025; 16:1559114. PMID: 40475950.
      View in: PubMed
    4. Baumgartner AJ, Hirt L, Kern DS, Thompson JA. Anodic stimulation of the subthalamic nucleus rescues cathodic stimulation-induced mood symptoms in Parkinson disease. Brain Stimul. 2025 May 08; 18(4):1085-1087. PMID: 40340021.
      View in: PubMed
    5. Timmermann O, Ojemann SG, Thompson JA, Treat L, Kern DS. Case Report of Bilateral Subthalamic Nucleus Deep Brain Stimulation in an Adolescent TUBB4A Patient: She Can Sit on a Horse. Mov Disord Clin Pract. 2025 Sep; 12(9):1432-1435. PMID: 40331309.
      View in: PubMed
    6. Kern D, Kundrick A, Rosenthal LS. Convention vs. innovation I: Skin biopsy for synuclein inclusions should now be used in the clinical setting. Parkinsonism Relat Disord. 2025 Jul; 136:107848. PMID: 40350322.
      View in: PubMed
    7. Tien R, Platt J, Mendlen M, Kern D, Ojemann S, Thompson J, Kramer D. Neurons in human motor thalamus encode reach kinematics and positional errors related to braking. Res Sq. 2025 Mar 26. PMID: 40195992.
      View in: PubMed
    8. Kern DS, Kramer DR. Neurohistological findings in deep brain stimulation: Current knowledge and gaps. Parkinsonism Relat Disord. 2025 Apr; 133:107297. PMID: 39870555.
      View in: PubMed
    9. Shah BR, Tanabe J, Jordan JE, Kern D, Harward SC, Feltrin FS, O'Suilliebhain P, Sharma VD, Maldjian JA, Boutet A, Mattay R, Sugrue LP, Narsinh K, Hetts S, Shah LM, Druzgal J, Lehman VT, Lee K, Khanpara S, Lad S, Kaufmann TJ. State of Practice on Transcranial MR-Guided Focused Ultrasound: A Report from the ASNR Standards and Guidelines Committee and ACR Commission on Neuroradiology Workgroup. AJNR Am J Neuroradiol. 2025 Jan 08; 46(1):2-10. PMID: 39572202.
      View in: PubMed
    10. Fullard ME, Dafoe A, Shelton E, Kern DS, Matlock DD, Morris MA. How Women and Men with Parkinson's Disease Approach Decision-Making for Deep Brain Stimulation Surgery. Mov Disord Clin Pract. 2025 Apr; 12(4):453-463. PMID: 39692295.
      View in: PubMed
    11. Baker SK, Radcliffe EM, Kramer DR, Ojemann S, Case M, Zarns C, Holt-Becker A, Raike RS, Baumgartner AJ, Kern DS, Thompson JA. Comparison of beta peak detection algorithms for data-driven deep brain stimulation programming strategies in Parkinson's disease. NPJ Parkinsons Dis. 2024 Aug 09; 10(1):150. PMID: 39122725.
      View in: PubMed
    12. Sakai JT, Tanabe J, Battula S, Zipperly M, Mikulich-Gilbertson SK, Kern DS, Thompson JA, Raymond K, Gerecht PD, Foster K, Abosch A. Deep brain stimulation for the treatment of substance use disorders: a promising approach requiring caution. Front Psychiatry. 2024; 15:1435109. PMID: 39071229.
      View in: PubMed
    13. Frassica M, Kern DS, Afshari M, Connolly AT, Wu C, Rowland N, Ramirez-Castaneda J, Ushe M, Salazar C, Mason X. Racial disparities in access to DBS: results of a real-world U.S. claims data analysis. Front Neurol. 2023; 14:1233684. PMID: 37602243.
      View in: PubMed
    14. Radcliffe EM, Baumgartner AJ, Kern DS, Al Borno M, Ojemann S, Kramer DR, Thompson JA. Oscillatory beta dynamics inform biomarker-driven treatment optimization for Parkinson's disease. J Neurophysiol. 2023 06 01; 129(6):1492-1504. PMID: 37198135.
      View in: PubMed
    15. Thompson JA, Hirt L, David-Gerecht P, Fasano A, Kramer DR, Ojemann SG, Kern DS. Comparison of Monopolar Review to Fixed Parameter Fractionation in Deep Brain Stimulation. Mov Disord Clin Pract. 2023 Jun; 10(6):987-991. PMID: 37332654.
      View in: PubMed
    16. Lewis S, Radcliffe E, Ojemann S, Kramer DR, Hirt L, Case M, Holt-Becker AB, Raike R, Kern DS, Thompson JA. Pilot Study to Investigate the Use of In-Clinic Sensing to Identify Optimal Stimulation Parameters for Deep Brain Stimulation Therapy in Parkinson's Disease. Neuromodulation. 2024 Apr; 27(3):509-519. PMID: 36797194.
      View in: PubMed
    17. Gibbons C, Wang N, Rajan S, Kern D, Palma JA, Kaufmann H, Freeman R. Cutaneous a-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease. Neurology. 2023 04 11; 100(15):e1529-e1539. PMID: 36657992.
      View in: PubMed
    18. McQueen RB, Gritz M, Kern D, Bemski JL, Shelton I, Meyer M, Kluger BM. Cost and Return on Investment of a Team-Based Palliative Care Program for Parkinson Disease. Neurol Clin Pract. 2022 Dec; 12(6):429-437. PMID: 36540151.
      View in: PubMed
    19. Marsili L, Keeling EG, Maciel R, Contarino MF, Zutt R, Okun MS, Almeida L, Deeb W, Kern D, Macias-Garcia D, Carrillo F, Mir P, Merola A, Espay AJ, Fasano A. Functional Movement Disorders and Deep Brain Stimulation: A Multi-Center Study. Mov Disord Clin Pract. 2023 Jan; 10(1):94-100. PMID: 36704077.
      View in: PubMed
    20. Tekriwal A, Baker S, Christensen E, Petersen-Jones H, Tien RN, Ojemann SG, Kern DS, Kramer DR, Felsen G, Thompson JA. Quantifying neuro-motor correlations during awake deep brain stimulation surgery using markerless tracking. Sci Rep. 2022 10 27; 12(1):18120. PMID: 36302865.
      View in: PubMed
    21. Baker S, Tekriwal A, Felsen G, Christensen E, Hirt L, Ojemann SG, Kramer DR, Kern DS, Thompson JA. Automatic extraction of upper-limb kinematic activity using deep learning-based markerless tracking during deep brain stimulation implantation for Parkinson's disease: A proof of concept study. PLoS One. 2022; 17(10):e0275490. PMID: 36264986.
      View in: PubMed
    22. Serva SN, Bernstein J, Thompson JA, Kern DS, Ojemann SG. An update on advanced therapies for Parkinson's disease: From gene therapy to neuromodulation. Front Surg. 2022; 9:863921. PMID: 36211256.
      View in: PubMed
    23. Jennings D, Huntwork-Rodriguez S, Henry AG, Sasaki JC, Meisner R, Diaz D, Solanoy H, Wang X, Negrou E, Bondar VV, Ghosh R, Maloney MT, Propson NE, Zhu Y, Maciuca RD, Harris L, Kay A, LeWitt P, King TA, Kern D, Ellenbogen A, Goodman I, Siderowf A, Aldred J, Omidvar O, Masoud ST, Davis SS, Arguello A, Estrada AA, de Vicente J, Sweeney ZK, Astarita G, Borin MT, Wong BK, Wong H, Nguyen H, Scearce-Levie K, Ho C, Troyer MD. Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease. Sci Transl Med. 2022 06 08; 14(648):eabj2658. PMID: 35675433.
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    24. Kern D, Korsmo M, Baumgartner AJ, Kramer D, Ojemann S, Case M, Holt-Becker AB, Raike R, Thompson JA. Methylphenidate effects on a clinically informative oscillatory signal within the subthalamic nucleus in Parkinson's disease during deep brain stimulation programming. Brain Stimul. 2022 May-Jun; 15(3):747-749. PMID: 35526817.
      View in: PubMed
    25. Baumgartner AJ, Thompson JA, Kern DS, Ojemann SG. Novel targets in deep brain stimulation for movement disorders. Neurosurg Rev. 2022 Aug; 45(4):2593-2613. PMID: 35511309.
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    26. Bally JF, Kern DS, Fearon C, Camargos S, Pereira da Silva-Junior F, Barbosa ER, Ozelius LJ, de Carvalho Aguiar P, Lang AE. DYT-TUBB4A (DYT4 Dystonia): Clinical Anthology of 11 Cases and Systematized Review. Mov Disord Clin Pract. 2022 Jul; 9(5):659-675. PMID: 35844288.
      View in: PubMed
    27. Hirt L, Kern DS, Ojemann S, Grassia F, Kramer D, Thompson JA. Use of Three-Dimensional Printed Brain Models During Deep Brain Stimulation Surgery Consultation for Patient Health Literacy: A Randomized Controlled Investigation. World Neurosurg. 2022 06; 162:e526-e533. PMID: 35306197.
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    28. Fearon C, Rawal S, Olszewska D, Alcaide-Leon P, Kern DS, Sharma S, Jaiswal SK, Murthy JMK, Ha AD, Schwartz RS, Fung VSC, Spears C, Tholanikunnel T, Almeida L, Hatano T, Oji Y, Hattori N, Shubham S, Kumar H, Bhidayasiri R, Laohathai C, Lang AE. Neuroimaging Pearls from the MDS Congress Video Challenge. Part 2: Acquired Disorders. Mov Disord Clin Pract. 2022 Apr; 9(3):311-325. PMID: 35402651.
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    29. Hirt L, Grassia F, Feuerstein J, Thompson JA, Ojemann S, Kern DS. Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus in Writer's Cramp: A Case Report. Tremor Other Hyperkinet Mov (N Y). 2021; 11:46. PMID: 34824889.
      View in: PubMed
    30. Baumgartner AJ, Kushida CA, Summers MO, Kern DS, Abosch A, Thompson JA. Basal Ganglia Local Field Potentials as a Potential Biomarker for Sleep Disturbance in Parkinson's Disease. Front Neurol. 2021; 12:765203. PMID: 34777232.
      View in: PubMed
    31. Thaker AA, Reddy KM, Thompson JA, Gerecht PD, Brown MS, Abosch A, Ojemann SG, Kern DS. Coronal Gradient Echo MRI to Visualize the Zona Incerta for Deep Brain Stimulation Targeting in Parkinson's Disease. Stereotact Funct Neurosurg. 2021; 99(5):443-450. PMID: 33902054.
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    32. Davis RA, Winston H, Gault JM, Kern DS, Mikulich-Gilbertson SK, Abosch A. Deep Brain Stimulation for OCD in a Patient With Comorbidities: Epilepsy, Tics, Autism, and Major Depressive Disorder. J Neuropsychiatry Clin Neurosci. 2021 Spring; 33(2):167-171. PMID: 33535803.
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    33. Kern DS, Fasano A, Thompson JA, Abosch A, Ojemann S, Munhoz RP. Constant Current versus Constant Voltage: Clinical Evidence Supporting a Fundamental Difference in the Modalities. Stereotact Funct Neurosurg. 2021; 99(2):171-175. PMID: 33227781.
      View in: PubMed
    34. Bally JF, Camargos S, Oliveira Dos Santos C, Kern DS, Lee T, Pereira da Silva-Junior F, Puga RD, Cardoso F, Barbosa ER, Yadav R, Ozelius LJ, de Carvalho Aguiar P, Lang AE. DYT-TUBB4A (DYT4 Dystonia): New Clinical and Genetic Observations. Neurology. 2021 04 06; 96(14):e1887-e1897. PMID: 32943487.
      View in: PubMed
    35. Kern DS, Uy D, Rhoades R, Ojemann S, Abosch A, Thompson JA. Discrete changes in brain volume after deep brain stimulation in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry. 2020 09; 91(9):928-937. PMID: 32651244.
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    36. Pang Y, Christenson J, Jiang F, Lei T, Rhoades R, Kern D, Thompson JA, Liu C. Automatic detection and quantification of hand movements toward development of an objective assessment of tremor and bradykinesia in Parkinson's disease. J Neurosci Methods. 2020 03 01; 333:108576. PMID: 31923452.
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    37. Deuel L, Collins AE, Maa EH, Barr JP, Kern DS. Dravet syndrome and parkinsonism: A case report investigating the dopaminergic system. Neurology. 2019 09 24; 93(13):595-596. PMID: 31444242.
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    38. Tekriwal A, Afshar NM, Santiago-Moreno J, Kuijper FM, Kern DS, Halpern CH, Felsen G, Thompson JA. Neural Circuit and Clinical Insights from Intraoperative Recordings During Deep Brain Stimulation Surgery. Brain Sci. 2019 Jul 20; 9(7). PMID: 31330813.
      View in: PubMed
    39. Kern DS, Picillo M, Thompson JA, Sammartino F, di Biase L, Munhoz RP, Fasano A. Interleaving Stimulation in Parkinson's Disease, Tremor, and Dystonia. Stereotact Funct Neurosurg. 2018; 96(6):379-391. PMID: 30654368.
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    40. Mestre TA, Pont-Sunyer C, Kausar F, Visanji NP, Ghate T, Connolly BS, Gasca-Salas C, Kern DS, Jain J, Slow EJ, Faust-Socher A, Kasten M, Wadia PM, Zadikoff C, Kumar P, de Bie RM, Thomsen T, Lang AE, Sch?le B, Klein C, Tolosa E, Marras C. Clustering of motor and nonmotor traits in leucine-rich repeat kinase 2 G2019S Parkinson's disease nonparkinsonian relatives: A multicenter family study. Mov Disord. 2018 Jul; 33(6):960-965. PMID: 29665080.
      View in: PubMed
    41. Arora S, Visanji NP, Mestre TA, Tsanas A, AlDakheel A, Connolly BS, Gasca-Salas C, Kern DS, Jain J, Slow EJ, Faust-Socher A, Lang AE, Little MA, Marras C. Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease. J Parkinsons Dis. 2018; 8(4):503-510. PMID: 30248062.
      View in: PubMed
    42. van den Heuvel L, Lim AS, Visanji NP, Huang J, Ghate T, Mestre TA, AlDakheel A, Connolly BS, Gasca-Salas C, Kern DS, Jain J, Slow EJ, Pondal M, Faust-Socher A, Rogaeva E, Tomlinson G, Lang AE, Marras C. Actigraphy Detects Greater Intra-Individual Variability During Gait in Non-Manifesting LRRK2 Mutation Carriers. J Parkinsons Dis. 2018; 8(1):131-139. PMID: 29480219.
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    43. Fullard ME, Thibault DP, Todaro V, Foster S, Katz L, Morgan R, Kern DS, Schwalb JM, Urrea Mendoza E, Dahodwala N, Shulman L, Willis AW. Sex disparities in health and health care utilization after Parkinson diagnosis: Rethinking PD associated disability. Parkinsonism Relat Disord. 2018 03; 48:45-50. PMID: 29273434.
      View in: PubMed
    44. Fullard ME, Thibault DP, Hill A, Fox J, Bhatti DE, Burack MA, Dahodwala N, Haberfeld E, Kern DS, Klepitskava OS, Urrea-Mendoza E, Myers P, Nutt J, Rafferty MR, Schwalb JM, Shulman LM, Willis AW. Utilization of rehabilitation therapy services in Parkinson disease in the United States. Neurology. 2017 Sep 12; 89(11):1162-1169. PMID: 28835397.
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    45. Visanji NP, Bhudhikanok GS, Mestre TA, Ghate T, Udupa K, AlDakheel A, Connolly BS, Gasca-Salas C, Kern DS, Jain J, Slow EJ, Faust-Socher A, Kim S, Azhu Valappil R, Kausar F, Rogaeva E, William Langston J, Tanner CM, Sch?le B, Lang AE, Goldman SM, Marras C. Heart rate variability in leucine-rich repeat kinase 2-associated Parkinson's disease. Mov Disord. 2017 04; 32(4):610-614. PMID: 28071824.
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    46. Tekriwal A, Kern DS, Tsai J, Ince NF, Wu J, Thompson JA, Abosch A. REM sleep behaviour disorder: prodromal and mechanistic insights for Parkinson's disease. J Neurol Neurosurg Psychiatry. 2017 05; 88(5):445-451. PMID: 27965397.
      View in: PubMed
    47. Picillo M, Vincos GB, Kern DS, Fox SH, Lang AE, Fasano A. Learning More from Finger Tapping in Parkinson's Disease: Up and Down from Dyskinesia to Bradykinesia. Mov Disord Clin Pract. 2016 Mar-Apr; 3(2):184-187. PMID: 30713911.
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    48. Kern DS, Lang AE. Successful treatment of functional palatal tremor: Insights into pathogenesis and management. Mov Disord. 2015 May; 30(6):875-6. PMID: 25914234.
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    49. Visanji NP, Marras C, Kern DS, Al Dakheel A, Gao A, Liu LW, Lang AE, Hazrati LN. Colonic mucosal a-synuclein lacks specificity as a biomarker for Parkinson disease. Neurology. 2015 Feb 10; 84(6):609-16. PMID: 25589666.
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    50. Lampe KJ, Kern DS, Mahoney MJ, Bjugstad KB. The administration of BDNF and GDNF to the brain via PLGA microparticles patterned within a degradable PEG-based hydrogel: Protein distribution and the glial response. J Biomed Mater Res A. 2011 Mar 01; 96(3):595-607. PMID: 21254391.
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    51. Bjugstad KB, Lampe K, Kern DS, Mahoney M. Biocompatibility of poly(ethylene glycol)-based hydrogels in the brain: an analysis of the glial response across space and time. J Biomed Mater Res A. 2010 Oct; 95(1):79-91. PMID: 20740603.
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    52. Kern DS, Maclean KN, Jiang H, Synder EY, Sladek JR, Bjugstad KB. Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice. Cell Transplant. 2011; 20(3):371-9. PMID: 20875225.
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    53. Bjugstad KB, Redmond DE, Lampe KJ, Kern DS, Sladek JR, Mahoney MJ. Biocompatibility of PEG-based hydrogels in primate brain. Cell Transplant. 2008; 17(4):409-15. PMID: 18522243.
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    54. Kern DS, Kumar R. Deep brain stimulation. Neurologist. 2007 Sep; 13(5):237-52. PMID: 17848864.
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    55. Kern DS, Semmler JG, Enoka RM. Long-term activity in upper- and lower-limb muscles of humans. J Appl Physiol (1985). 2001 Nov; 91(5):2224-32. PMID: 11641365.
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