 NAV1.2 Voltage-Gated Sodium Channel
"NAV1.2 Voltage-Gated Sodium Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A voltage-gated sodium channel subtype that mediates the sodium ion permeability of excitable membranes. Defects in the SCN2A gene which codes for the alpha subunit of this sodium channel are associated with benign familial infantile seizures type 3, and early infantile epileptic encephalopathy type 11.
| Descriptor ID |
D062551
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| MeSH Number(s) |
D12.776.157.530.400.875.750.200 D12.776.543.550.450.875.750.200 D12.776.543.585.400.875.750.200 D12.776.631.960.200
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| Concept/Terms |
NAV1.2 Voltage-Gated Sodium Channel- NAV1.2 Voltage-Gated Sodium Channel
- NAV1.2 Voltage Gated Sodium Channel
- Type 2 Voltage-Gated Sodium Channel
- Type 2 Voltage Gated Sodium Channel
- Voltage-Gated Sodium Channel Type 2
- Voltage Gated Sodium Channel Type 2
Voltage-Gated Sodium Channel Type 2 Subunit alpha- Voltage-Gated Sodium Channel Type 2 Subunit alpha
- Voltage Gated Sodium Channel Type 2 Subunit alpha
- Voltage-Gated Sodium Channel Type 2 alpha Subunit
- Voltage Gated Sodium Channel Type 2 alpha Subunit
- Sodium Channel, Voltage-Gated, Type II, alpha 1 Subunit
- Sodium Channel Protein Type 2 Subunit alpha
- Sodium Channel, Voltage-Gated, Type II, alpha 1
- NAV1.2 alpha Subunit
- SCN2A Sodium Channel alpha Subunit
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Below are MeSH descriptors whose meaning is more general than "NAV1.2 Voltage-Gated Sodium Channel".
Below are MeSH descriptors whose meaning is more specific than "NAV1.2 Voltage-Gated Sodium Channel".
This graph shows the total number of publications written about "NAV1.2 Voltage-Gated Sodium Channel" by people in this website by year, and whether "NAV1.2 Voltage-Gated Sodium Channel" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2014 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 | | 2023 | 1 | 0 | 1 | | 2025 | 3 | 0 | 3 |
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Below are the most recent publications written about "NAV1.2 Voltage-Gated Sodium Channel" by people in Profiles.
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Tamura S, Nelson AD, Spratt PWE, Hamada EC, Zhou X, Kyoung H, Li Z, Arnould C, Barskyi V, Krupkin B, Young K, Zhao J, Holden SS, Sahagun A, Keeshen CM, Lu C, Ben-Shalom R, Taloma SE, Schamiloglu S, Li YC, Min L, Jenkins PM, Pan JQ, Paz JT, Sanders SJ, Matharu N, Ahituv N, Bender KJ. CRISPR activation for SCN2A-related neurodevelopmental disorders. Nature. 2025 Oct; 646(8086):983-991.
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Goad BS, Rodda J, Allen M, Bamborschke D, Overmars I, Kerr RJ, Bushlin I, Chopra S, Coorg R, Dabscheck G, Freeman JL, Mackay MT, Devinsky O, Guerrini R, Parrini E, Bölsterli B, Hughes I, Huh LL, Kamate M, Kunz AB, Melikishvili G, Miteff C, Myers KA, Olson HE, Poduri A, Pillai S, Riney CK, Sinclair A, Calvert S, Reynolds TQ, Martinez AR, Russo A, Sadleir LG, Sanchez-Albisua I, Sartori S, Shea S, Smith-Hicks CL, Spooner CG, Thomas RH, Ardern-Holmes SL, Webster RI, Valeriani M, Veggiotti P, Masnada S, Ware TL, Yoong M, Berecki G, De Dominicis A, Specchio N, Trivisano M, Møller RS, Wolff M, Fazeli W, Scheffer I, Howell KB. Development and Adaptive Function in Individuals With SCN2A-Related Disorders. Neurology. 2025 Aug 12; 105(3):e213868.
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Garcia JD, Wang C, Alexander RPD, Banks E, Fenton T, DeKeyser JM, Abramova TV, George AL, Ben-Shalom R, Hackos DH, Bender KJ. Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability. Elife. 2025 Jul 15; 14.
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Schamiloglu S, Wu H, Zhou M, Kwan AC, Bender KJ. Dynamic Foraging Behavior Performance Is Not Affected by Scn2a Haploinsufficiency. eNeuro. 2023 12; 10(12).
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Bielopolski N, Heyman E, Bassan H, BenZeev B, Tzadok M, Ginsberg M, Blumkin L, Michaeli Y, Sokol R, Yosha-Orpaz N, Hady-Cohen R, Banne E, Lev D, Lerman-Sagie T, Wald-Altman S, Nissenkorn A. "Virtual patch clamp analysis" for predicting the functional significance of pathogenic variants in sodium channels. Epilepsy Res. 2022 10; 186:107002.
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Berg AT, Palac H, Wilkening G, Zelko F, Schust Meyer L. SCN2A-Developmental and Epileptic Encephalopathies: Challenges to trial-readiness for non-seizure outcomes. Epilepsia. 2021 01; 62(1):258-268.
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Foster LA, Johnson MR, MacDonald JT, Karachunski PI, Henry TR, Nascene DR, Moran BP, Raymond GV. Infantile Epileptic Encephalopathy Associated With SCN2A Mutation Responsive to Oral Mexiletine. Pediatr Neurol. 2017 01; 66:108-111.
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Martin HC, Kim GE, Pagnamenta AT, Murakami Y, Carvill GL, Meyer E, Copley RR, Rimmer A, Barcia G, Fleming MR, Kronengold J, Brown MR, Hudspith KA, Broxholme J, Kanapin A, Cazier JB, Kinoshita T, Nabbout R, Bentley D, McVean G, Heavin S, Zaiwalla Z, McShane T, Mefford HC, Shears D, Stewart H, Kurian MA, Scheffer IE, Blair E, Donnelly P, Kaczmarek LK, Taylor JC. Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis. Hum Mol Genet. 2014 Jun 15; 23(12):3200-11.
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