 Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM.
| Descriptor ID |
D000071248
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| MeSH Number(s) |
D12.644.360.024.314.650 D12.776.157.057.080.650 D12.776.157.725.813.875 D12.776.476.024.394.650 D12.776.660.675.650 D12.776.664.962.813.875 D12.776.930.617.650
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha".
Below are MeSH descriptors whose meaning is more specific than "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha".
This graph shows the total number of publications written about "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" by people in this website by year, and whether "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2010 | 0 | 2 | 2 | | 2012 | 0 | 2 | 2 | | 2013 | 0 | 3 | 3 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 2 | 2 | | 2016 | 0 | 2 | 2 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2020 | 0 | 1 | 1 | | 2021 | 1 | 1 | 2 | | 2022 | 0 | 3 | 3 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" by people in Profiles.
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Wang XX, Myakala K, Libby AE, Krawczyk E, Panov J, Jones BA, Bhasin K, Shults N, Qi Y, Krausz KW, Zerfas PM, Takahashi S, Daneshpajouhnejad P, Titievsky A, Taranenko E, Billon C, Chatterjee A, Elgendy B, Walker JK, Albanese C, Kopp JB, Rosenberg AZ, Gonzalez FJ, Guha U, Brodsky L, Burris TP, Levi M. Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney. Am J Pathol. 2023 12; 193(12):1969-1987.
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Huot JR, Pin F, Chatterjee R, Bonetto A. PGC1a overexpression preserves muscle mass and function in cisplatin-induced cachexia. J Cachexia Sarcopenia Muscle. 2022 10; 13(5):2480-2491.
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Zhang L, Wang X, Yu W, Ying J, Fang P, Zheng Q, Feng X, Hu J, Xiao F, Chen S, Wei G, Lin Y, Liu X, Yang D, Fang Y, Xu G, Hua F. CB2R Activation Regulates TFEB-Mediated Autophagy and Affects Lipid Metabolism and Inflammation of Astrocytes in POCD. Front Immunol. 2022; 13:836494.
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Raghavan S, Kundumani-Sridharan V, Kumar S, White CW, Das KC. Thioredoxin Prevents Loss of UCP2 in Hyperoxia via MKK4-p38 MAPK-PGC1a Signaling and Limits Oxygen Toxicity. Am J Respir Cell Mol Biol. 2022 03; 66(3):323-336.
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Jankowski CM, Wilson MP, MaWhinney S, Reusch J, Knaub L, Hull S, Erlandson KM. Blunted Muscle Mitochondrial Responses to Exercise Training in Older Adults With HIV. J Infect Dis. 2021 08 16; 224(4):679-683.
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Keleher MR, Erickson K, Smith HA, Kechris KJ, Yang IV, Dabelea D, Friedman JE, Boyle KE, Jansson T. Placental Insulin/IGF-1 Signaling, PGC-1a, and Inflammatory Pathways Are Associated With Metabolic Outcomes at 4-6 Years of Age: The ECHO Healthy Start Cohort. Diabetes. 2021 03; 70(3):745-751.
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Keller A, Hull SE, Elajaili H, Johnston A, Knaub LA, Chun JH, Walker L, Nozik-Grayck E, Reusch JEB. (-)-Epicatechin Modulates Mitochondrial Redox in Vascular Cell Models of Oxidative Stress. Oxid Med Cell Longev. 2020; 2020:6392629.
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McCoin CS, Von Schulze A, Allen J, Fuller KNZ, Xia Q, Koestler DC, Houchen CJ, Maurer A, Dorn GW, Shankar K, Morris EM, Thyfault JP. Sex modulates hepatic mitochondrial adaptations to high-fat diet and physical activity. Am J Physiol Endocrinol Metab. 2019 08 01; 317(2):E298-E311.
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Prola A, Nichtova Z, Pires Da Silva J, Piquereau J, Monceaux K, Guilbert A, Gressette M, Ventura-Clapier R, Garnier A, Zahradnik I, Novotova M, Lemaire C. Endoplasmic reticulum stress induces cardiac dysfunction through architectural modifications and alteration of mitochondrial function in cardiomyocytes. Cardiovasc Res. 2019 02 01; 115(2):328-342.
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Granata C, Jamnick NA, Bishop DJ. Principles of Exercise Prescription, and How They Influence Exercise-Induced Changes of Transcription Factors and Other Regulators of Mitochondrial Biogenesis. Sports Med. 2018 07; 48(7):1541-1559.
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