 Inflammasomes
"Inflammasomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Multiprotein complexes that mediate the activation of CASPASE-1. Dysregulation of inflammasomes has also been linked to a number of autoinflammatory and autoimmune disorders.
| Descriptor ID |
D058847
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| MeSH Number(s) |
D05.500.224
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Inflammasomes".
Below are MeSH descriptors whose meaning is more specific than "Inflammasomes".
This graph shows the total number of publications written about "Inflammasomes" by people in this website by year, and whether "Inflammasomes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 | | 2011 | 1 | 1 | 2 | | 2012 | 8 | 2 | 10 | | 2013 | 5 | 0 | 5 | | 2014 | 6 | 1 | 7 | | 2015 | 8 | 0 | 8 | | 2016 | 6 | 3 | 9 | | 2017 | 5 | 2 | 7 | | 2018 | 5 | 1 | 6 | | 2019 | 2 | 2 | 4 | | 2020 | 4 | 4 | 8 | | 2021 | 3 | 0 | 3 | | 2022 | 0 | 2 | 2 | | 2023 | 3 | 5 | 8 | | 2024 | 1 | 3 | 4 | | 2025 | 2 | 2 | 4 | | 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Inflammasomes" by people in Profiles.
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Lai YH, Liu YH, Chen JY, Lee CT, Wang SY, Chiang-Ni C, Luo YH, Chi CY, Noda T, Lu SL, Tsai YS, Wu JJ, Tsai PJ. Endothelial NLRP3 inflammasome activation drives immunothrombosis in Streptococcus pyogenes infection. Life Sci. 2026 Mar 15; 389:124239.
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Nowak KL, Chonchol M. Targeting Inflammation in CKD. Am J Kidney Dis. 2025 Dec; 86(6):803-813.
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Bauernfried S, Komar T, Sterle K, Tanzer MC, Horswill AR, Mann M, Hornung V. Inflammasome-independent IL-1ß activation via staphopain A protease of Staphylococcus aureus. J Biol Chem. 2025 10; 301(10):110574.
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Anton PE, Twardy S, Nagpal P, Moreno JA, Burchill MA, Chatterjee A, Busquet N, Mesches M, Kovacs EJ, McCullough RL. Suppression of NF-?B/NLRP3 by nanoligomer therapy mitigates ethanol and advanced age-related neuroinflammation. J Leukoc Biol. 2025 Apr 23; 117(4).
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Kent A, Yee Mon KJ, Hutchins Z, Putzel G, Zhigarev D, Grier A, Jia B, Kortlever RM, Barbet G, Evan GI, Blander JM. A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis. Nat Immunol. 2025 Jan; 26(1):53-67.
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Huynh TN, Toperzer J, Scherer A, Gumina A, Brunetti T, Mansour MK, Markovitz DM, Russo BC. Vimentin regulates mitochondrial ROS production and inflammatory responses of neutrophils. Front Immunol. 2024; 15:1416275.
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Tengesdal IW, Banks M, Dinarello CA, Marchetti C. Screening NLRP3 drug candidates in clinical development: lessons from existing and emerging technologies. Front Immunol. 2024; 15:1422249.
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Chaudhary A, He Z, Atwood DJ, Miyazaki M, Oto OA, Davidoff A, Edelstein CL. Raising serum uric acid with a uricase inhibitor worsens PKD in rat and mouse models. Am J Physiol Renal Physiol. 2024 Jun 01; 326(6):F1004-F1015.
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Nagao PE, Santos L, Keestra-Gounder AM. Editorial: Inflammasomes in infectious diseases, cell death and ROS generation: stimulation by microorganisms and membrane-derived microvesicles. Front Immunol. 2024; 15:1378506.
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Tengesdal IW, Dinarello CA, Marchetti C. NLRP3 and cancer: Pathogenesis and therapeutic opportunities. Pharmacol Ther. 2023 11; 251:108545.
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