 Maturation-Promoting Factor
"Maturation-Promoting Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2.
| Descriptor ID |
D016200
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| MeSH Number(s) |
D08.811.913.696.620.682.700.646.500.984 D12.644.360.250.580 D12.776.167.200.580 D12.776.476.250.580
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| Concept/Terms |
Maturation-Promoting Factor- Maturation-Promoting Factor
- Maturation Promoting Factor
- Histone H1 Kinase, M-Phase-Specific
- Histone H1 Kinase, M Phase Specific
- Mitosis-Promoting Factor
- Mitosis Promoting Factor
- Histone H1 Kinase, Growth-Associated
- Histone H1 Kinase, Growth Associated
- M Phase-Promoting Factor
- M Phase Promoting Factor
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Below are MeSH descriptors whose meaning is more general than "Maturation-Promoting Factor".
Below are MeSH descriptors whose meaning is more specific than "Maturation-Promoting Factor".
This graph shows the total number of publications written about "Maturation-Promoting Factor" by people in this website by year, and whether "Maturation-Promoting Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Maturation-Promoting Factor" by people in Profiles.
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Blake-Hodek KA, Williams BC, Zhao Y, Castilho PV, Chen W, Mao Y, Yamamoto TM, Goldberg ML. Determinants for activation of the atypical AGC kinase Greatwall during M phase entry. Mol Cell Biol. 2012 Apr; 32(8):1337-53.
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Choi T, Rulong S, Resau J, Fukasawa K, Matten W, Kuriyama R, Mansour S, Ahn N, Vande Woude GF. Mos/mitogen-activated protein kinase can induce early meiotic phenotypes in the absence of maturation-promoting factor: a novel system for analyzing spindle formation during meiosis I. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4730-5.
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Klymkowsky MW, Maynell LA. MPF-induced breakdown of cytokeratin filament organization in the maturing Xenopus oocyte depends upon the translation of maternal mRNAs. Dev Biol. 1989 Aug; 134(2):479-85.
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