 Cathepsin B
"Cathepsin B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.
| Descriptor ID |
D002401
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| MeSH Number(s) |
D08.811.277.656.224.125 D08.811.277.656.262.500.133 D08.811.277.656.300.200.133
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cathepsin B".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin B".
This graph shows the total number of publications written about "Cathepsin B" by people in this website by year, and whether "Cathepsin B" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "Cathepsin B" by people in Profiles.
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Morrone C, Smirnova NF, Jeridi A, Kneidinger N, Hollauer C, Schupp JC, Kaminski N, Jenne D, Eickelberg O, Yildirim A?. Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndrome. Eur Respir J. 2021 05; 57(5).
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Johnson TK, Belcher DJ, Sousa CA, Carzoli JP, Visavadiya NP, Khamoui AV, Whitehurst M, Zourdos MC. Low-volume acute multi-joint resistance exercise elicits a circulating brain-derived neurotrophic factor response but not a cathepsin B response in well-trained men. Appl Physiol Nutr Metab. 2020 Dec; 45(12):1332-1338.
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Paschoalin T, Martens AA, Omori ?T, Pereira FV, Juliano L, Travassos LR, Machado-Santelli GM, Cunha RLOR. Antitumor effect of chiral organotelluranes elicited in a murine melanoma model. Bioorg Med Chem. 2019 06 15; 27(12):2537-2545.
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Weiss-Sadan T, Maimoun D, Oelschlagel D, Kaschani F, Misiak D, Gaikwad H, Ben-Nun Y, Merquiol E, Anaki A, Tsvirkun D, Kaiser M, Michl P, Gotsman I, Blum G. Cathepsins Drive Anti-Inflammatory Activity by Regulating Autophagy and Mitochondrial Dynamics in Macrophage Foam Cells. Cell Physiol Biochem. 2019; 53(3):550-572.
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Venkataraman S, Birks DK, Balakrishnan I, Alimova I, Harris PS, Patel PR, Handler MH, Dubuc A, Taylor MD, Foreman NK, Vibhakar R. MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype-associated genes in medulloblastoma. J Biol Chem. 2013 Jan 18; 288(3):1918-28.
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Duncan JA, Gao X, Huang MT, O'Connor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP. Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome. J Immunol. 2009 May 15; 182(10):6460-9.
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Rossi S, Stoppani E, Martinet W, Bonetto A, Costelli P, Giuliani R, Colombo F, Preti A, Marchesini S, Fanzani A. The cytosolic sialidase Neu2 is degraded by autophagy during myoblast atrophy. Biochim Biophys Acta. 2009 Aug; 1790(8):817-28.
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Reisenauer A, Eickelberg O, Wille A, Heimburg A, Reinhold A, Sloane BF, Welte T, B?hling F. Increased carcinogenic potential of myeloid tumor cells induced by aberrant TGF-beta1-signaling and upregulation of cathepsin B. Biol Chem. 2007 Jun; 388(6):639-50.
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Tao Y, Kim J, Faubel S, Wu JC, Falk SA, Schrier RW, Edelstein CL. Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6954-9.
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Edelstein CL, Wieder ED, Yaqoob MM, Gengaro PE, Burke TJ, Nemenoff RA, Schrier RW. The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):7662-6.
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