 Calpain
"Calpain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
| Descriptor ID |
D002154
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| MeSH Number(s) |
D08.811.277.656.262.500.120 D08.811.277.656.300.200.120
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| Concept/Terms |
Calpain- Calpain
- Calcium-Activated Protease
- Calcium Activated Protease
- Protease, Calcium-Activated
- Calcium-Dependent Neutral Proteinase
- Calcium Dependent Neutral Proteinase
- Neutral Proteinase, Calcium-Dependent
- Proteinase, Calcium-Dependent Neutral
- Calcium-Dependent Neutral Protease
- Calcium Dependent Neutral Protease
- Neutral Protease, Calcium-Dependent
- Protease, Calcium-Dependent Neutral
- Desminase
- Ca2+-Activated Protease
- Ca2+ Activated Protease
- Protease, Ca2+-Activated
- Calcium-Activated Neutral Proteinase
- Calcium Activated Neutral Proteinase
- Neutral Proteinase, Calcium-Activated
- Proteinase, Calcium-Activated Neutral
- Calcium-Activated Neutral Protease
- Calcium Activated Neutral Protease
- Neutral Protease, Calcium-Activated
- Protease, Calcium-Activated Neutral
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Below are MeSH descriptors whose meaning is more general than "Calpain".
Below are MeSH descriptors whose meaning is more specific than "Calpain".
This graph shows the total number of publications written about "Calpain" by people in this website by year, and whether "Calpain" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1996 | 2 | 0 | 2 | | 1997 | 1 | 3 | 4 | | 1999 | 1 | 1 | 2 | | 2000 | 4 | 1 | 5 | | 2001 | 1 | 1 | 2 | | 2003 | 2 | 0 | 2 | | 2004 | 1 | 2 | 3 | | 2005 | 1 | 2 | 3 | | 2006 | 2 | 1 | 3 | | 2007 | 2 | 0 | 2 | | 2008 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 1 | 2 | | 2014 | 1 | 1 | 2 | | 2016 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Calpain" by people in Profiles.
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Whitmore C, Pratt EPS, Anderson L, Bradley K, Latour SM, Hashmi MN, Urazaev AK, Weilbaecher R, Davie JK, Wang WH, Hockerman GH, Pond AL. The ERG1a potassium channel increases basal intracellular calcium concentration and calpain activity in skeletal muscle cells. Skelet Muscle. 2020 01 16; 10(1):1.
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Gonz?lez MI. Calpain-dependent cleavage of GABAergic proteins during epileptogenesis. Epilepsy Res. 2019 11; 157:106206.
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Lam PM, Gonz?lez MI. Calpain activation and neuronal death during early epileptogenesis. Neurobiol Dis. 2019 04; 124:141-151.
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Guo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, Hall D, Wu J, Shi Y, Zhu Q, Chen C, Thiel WH, Zhan X, Weiss RM, Zhan F, Musselman CA, Pufall M, Zhu W, Au KF, Hong J, Anderson ME, Grueter CE, Song LS. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018 12 21; 362(6421).
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Tesic V, Perovic M, Zaletel I, Jovanovic M, Puskas N, Ruzdijic S, Kanazir S. A single high dose of dexamethasone increases GAP-43 and synaptophysin in the hippocampus of aged rats. Exp Gerontol. 2017 11; 98:62-69.
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Lam PM, Carlsen J, Gonz?lez MI. A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy. Neurobiol Dis. 2017 Jun; 102:1-10.
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Bochner R, Samuelov L, Sarig O, Li Q, Adase CA, Isakov O, Malchin N, Vodo D, Shayevitch R, Peled A, Yu BD, Fainberg G, Warshauer E, Adir N, Erez N, Gat A, Gottlieb Y, Rogers T, Pavlovsky M, Goldberg I, Shomron N, Sandilands A, Campbell LE, MacCallum S, McLean WHI, Ast G, Gallo RL, Uitto J, Sprecher E. Calpain 12 Function Revealed through the Study of an Atypical Case of Autosomal Recessive Congenital Ichthyosis. J Invest Dermatol. 2017 02; 137(2):385-393.
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Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O. Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice. Aging Cell. 2016 06; 15(3):488-98.
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Sleiman PM, Wang ML, Cianferoni A, Aceves S, Gonsalves N, Nadeau K, Bredenoord AJ, Furuta GT, Spergel JM, Hakonarson H. GWAS identifies four novel eosinophilic esophagitis loci. Nat Commun. 2014 Nov 19; 5:5593.
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Kottyan LC, Davis BP, Sherrill JD, Liu K, Rochman M, Kaufman K, Weirauch MT, Vaughn S, Lazaro S, Rupert AM, Kohram M, Stucke EM, Kemme KA, Magnusen A, He H, Dexheimer P, Chehade M, Wood RA, Pesek RD, Vickery BP, Fleischer DM, Lindbad R, Sampson HA, Mukkada VA, Putnam PE, Abonia JP, Martin LJ, Harley JB, Rothenberg ME. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. Nat Genet. 2014 Aug; 46(8):895-900.
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