 DNA Primase
"DNA Primase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single-stranded DNA-dependent RNA polymerase that functions to initiate, or prime, DNA synthesis by synthesizing oligoribonucleotide primers. EC 2.7.7.-.
| Descriptor ID |
D019915
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| MeSH Number(s) |
D08.811.913.696.445.735.270.375
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| Concept/Terms |
Bacteriophage T7 Gene 4 Protein- Bacteriophage T7 Gene 4 Protein
- T7 DNA-Priming Protein
- DNA-Priming Protein, T7
- Protein, T7 DNA-Priming
- T7 DNA Priming Protein
- T7 gene-4 protein
- T7 gene 4 protein
- T7 DNA Primase-Helicase Protein
- T7 DNA Primase Helicase Protein
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Below are MeSH descriptors whose meaning is more general than "DNA Primase".
Below are MeSH descriptors whose meaning is more specific than "DNA Primase".
This graph shows the total number of publications written about "DNA Primase" by people in this website by year, and whether "DNA Primase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 | | 1994 | 0 | 2 | 2 | | 1995 | 0 | 3 | 3 | | 1996 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 1999 | 4 | 0 | 4 | | 2000 | 2 | 0 | 2 | | 2002 | 1 | 0 | 1 | | 2004 | 3 | 1 | 4 | | 2005 | 1 | 0 | 1 | | 2008 | 2 | 0 | 2 | | 2009 | 3 | 0 | 3 | | 2010 | 2 | 0 | 2 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Primase" by people in Profiles.
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Zaug AJ, Goodrich KJ, Song JJ, Sullivan AE, Cech TR. Reconstitution of a telomeric replicon organized by CST. Nature. 2022 08; 608(7924):819-825.
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Zaug AJ, Lim CJ, Olson CL, Carilli MT, Goodrich KJ, Wuttke DS, Cech TR. CST does not evict elongating telomerase but prevents initiation by ssDNA binding. Nucleic Acids Res. 2021 11 18; 49(20):11653-11665.
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Dickerson SM, Kuchta RD. Protein Displacement by Herpes Helicase-Primase and the Key Role of UL42 during Helicase-Coupled DNA Synthesis by the Herpes Polymerase. Biochemistry. 2017 05 30; 56(21):2651-2662.
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Weller SK, Kuchta RD. The DNA helicase-primase complex as a target for herpes viral infection. Expert Opin Ther Targets. 2013 Oct; 17(10):1119-32.
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Katsumata K, Weinberg A, Chono K, Takakura S, Kontani T, Suzuki H. Susceptibility of herpes simplex virus isolated from genital herpes lesions to ASP2151, a novel helicase-primase inhibitor. Antimicrob Agents Chemother. 2012 Jul; 56(7):3587-91.
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Chen Y, Bai P, Mackay S, Korza G, Carson JH, Kuchta RD, Weller SK. Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation. J Virol. 2011 Jan; 85(2):968-78.
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Urban M, Joubert N, Purse BW, Hocek M, Kuchta RD. Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate. Biochemistry. 2010 Feb 02; 49(4):727-35.
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Urban M, Joubert N, Hocek M, Alexander RE, Kuchta RD. Herpes simplex virus-1 DNA primase: a remarkably inaccurate yet selective polymerase. Biochemistry. 2009 Nov 24; 48(46):10866-81.
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Cavanaugh NA, Ramirez-Aguilar KA, Urban M, Kuchta RD. Herpes simplex virus-1 helicase-primase: roles of each subunit in DNA binding and phosphodiester bond formation. Biochemistry. 2009 Nov 03; 48(43):10199-207.
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Kuchta RD, Stengel G. Mechanism and evolution of DNA primases. Biochim Biophys Acta. 2010 May; 1804(5):1180-9.
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