 Enzyme Inhibitors
"Enzyme Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
| Descriptor ID |
D004791
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| MeSH Number(s) |
D27.505.519.389
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Enzyme Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Enzyme Inhibitors".
This graph shows the total number of publications written about "Enzyme Inhibitors" by people in this website by year, and whether "Enzyme Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 0 | 1 | 1 | | 1983 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 1995 | 3 | 4 | 7 | | 1996 | 6 | 14 | 20 | | 1997 | 6 | 24 | 30 | | 1998 | 4 | 16 | 20 | | 1999 | 11 | 18 | 29 | | 2000 | 7 | 28 | 35 | | 2001 | 7 | 39 | 46 | | 2002 | 14 | 48 | 62 | | 2003 | 13 | 33 | 46 | | 2004 | 9 | 37 | 46 | | 2005 | 11 | 20 | 31 | | 2006 | 9 | 21 | 30 | | 2007 | 14 | 17 | 31 | | 2008 | 9 | 23 | 32 | | 2009 | 9 | 21 | 30 | | 2010 | 12 | 16 | 28 | | 2011 | 15 | 12 | 27 | | 2012 | 13 | 20 | 33 | | 2013 | 6 | 19 | 25 | | 2014 | 15 | 18 | 33 | | 2015 | 10 | 14 | 24 | | 2016 | 8 | 11 | 19 | | 2017 | 3 | 5 | 8 | | 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "Enzyme Inhibitors" by people in Profiles.
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DiNardo CD, Stein EM, de Botton S, Roboz GJ, Altman JK, Mims AS, Swords R, Collins RH, Mannis GN, Pollyea DA, Donnellan W, Fathi AT, Pigneux A, Erba HP, Prince GT, Stein AS, Uy GL, Foran JM, Traer E, Stuart RK, Arellano ML, Slack JL, Sekeres MA, Willekens C, Choe S, Wang H, Zhang V, Yen KE, Kapsalis SM, Yang H, Dai D, Fan B, Goldwasser M, Liu H, Agresta S, Wu B, Attar EC, Tallman MS, Stone RM, Kantarjian HM. Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML. N Engl J Med. 2018 Jun 21; 378(25):2386-2398.
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Lounsbury N, Eidem T, Colquhoun J, Mateo G, Abou-Gharbia M, Dunman PM, Childers WE. Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin. Bioorg Med Chem Lett. 2018 04 01; 28(6):1127-1131.
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Kalita D, Holm DG, LaBarbera DV, Petrash JM, Jayanty SS. Inhibition of a-glucosidase, a-amylase, and aldose reductase by potato polyphenolic compounds. PLoS One. 2018; 13(1):e0191025.
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Yan C, Theodorescu D. RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer. Pharmacol Rev. 2018 01; 70(1):1-11.
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Fontenot J, Loetz EC, Ishiki M, Bland ST. Monoacylglycerol lipase inhibition alters social behavior in male and female rats after post-weaning social isolation. Behav Brain Res. 2018 04 02; 341:146-153.
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Summers SR, Sprenger KG, Pfaendtner J, Marchant J, Summers MF, Kaar JL. Mechanism of Competitive Inhibition and Destabilization of Acidothermus cellulolyticus Endoglucanase 1 by Ionic Liquids. J Phys Chem B. 2017 12 07; 121(48):10793-10803.
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Craighead DH, Alexander LM. Menthol-Induced Cutaneous Vasodilation Is Preserved in Essential Hypertensive Men and Women. Am J Hypertens. 2017 Nov 06; 30(12):1156-1162.
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Bain AR, Weil BR, Diehl KJ, Greiner JJ, Stauffer BL, DeSouza CA. Insufficient sleep is associated with impaired nitric oxide-mediated endothelium-dependent vasodilation. Atherosclerosis. 2017 Oct; 265:41-46.
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Salinas G, Gao W, Wang Y, Bonilla M, Yu L, Novikov A, Virginio VG, Ferreira HB, Vieites M, Gladyshev VN, Gambino D, Dai S. The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I). Antioxid Redox Signal. 2017 Dec 20; 27(18):1491-1504.
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Stein EM, DiNardo CD, Pollyea DA, Fathi AT, Roboz GJ, Altman JK, Stone RM, DeAngelo DJ, Levine RL, Flinn IW, Kantarjian HM, Collins R, Patel MR, Frankel AE, Stein A, Sekeres MA, Swords RT, Medeiros BC, Willekens C, Vyas P, Tosolini A, Xu Q, Knight RD, Yen KE, Agresta S, de Botton S, Tallman MS. Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia. Blood. 2017 08 10; 130(6):722-731.
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