 Complement Activation
"Complement Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The sequential activation of serum COMPLEMENT PROTEINS to create the COMPLEMENT MEMBRANE ATTACK COMPLEX. Factors initiating complement activation include ANTIGEN-ANTIBODY COMPLEXES, microbial ANTIGENS, or cell surface POLYSACCHARIDES.
| Descriptor ID |
D003167
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| MeSH Number(s) |
G12.274
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| Concept/Terms |
Complement Activation- Complement Activation
- Activation, Complement
- Activations, Complement
- Complement Activations
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Below are MeSH descriptors whose meaning is more general than "Complement Activation".
Below are MeSH descriptors whose meaning is more specific than "Complement Activation".
This graph shows the total number of publications written about "Complement Activation" by people in this website by year, and whether "Complement Activation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 2 | 3 | | 1996 | 0 | 3 | 3 | | 1997 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 2 | 2 | | 2000 | 2 | 1 | 3 | | 2001 | 0 | 2 | 2 | | 2002 | 2 | 2 | 4 | | 2003 | 6 | 1 | 7 | | 2004 | 1 | 3 | 4 | | 2005 | 1 | 1 | 2 | | 2006 | 3 | 5 | 8 | | 2007 | 1 | 3 | 4 | | 2008 | 3 | 1 | 4 | | 2010 | 3 | 2 | 5 | | 2011 | 3 | 3 | 6 | | 2012 | 2 | 2 | 4 | | 2013 | 4 | 6 | 10 | | 2014 | 5 | 4 | 9 | | 2015 | 3 | 2 | 5 | | 2016 | 8 | 5 | 13 | | 2017 | 6 | 3 | 9 | | 2018 | 6 | 8 | 14 | | 2019 | 7 | 6 | 13 | | 2020 | 6 | 6 | 12 | | 2021 | 4 | 5 | 9 | | 2022 | 3 | 9 | 12 | | 2023 | 1 | 7 | 8 | | 2024 | 2 | 3 | 5 | | 2025 | 3 | 1 | 4 |
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Below are the most recent publications written about "Complement Activation" by people in Profiles.
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Banda NK, Moreland LW, Deane KD, Simberg D, Scheinman RI, Frank RM, Seifert JA, Lau R, Pitzalis C, Lewis MJ, Holers VM. Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation. Sci Rep. 2025 Jun 04; 15(1):19633.
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Wheeler EA, Lenhart-Pendergrass PM, Rysavy NM, Poch KR, Caceres SM, Calhoun KM, Serban KA, Nick JA, Malcolm KC. Divergent host humoral innate immune response to the smooth-to-rough adaptation of Mycobacterium abscessus in chronic infection. Front Cell Infect Microbiol. 2025; 15:1445660.
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Donado CA, Theisen E, Zhang F, Nathan A, Fairfield ML, Rupani KV, Jones D, Johannes KP, Raychaudhuri S, Dwyer DF, Jonsson AH, Brenner MB. Granzyme K activates the entire complement cascade. Nature. 2025 May; 641(8061):211-221.
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Nandakumar V, Braun KMP, Willrich MAV. Challenges for complement functional assays in the clinical laboratory: From test validation to clinical interpretation. J Immunol Methods. 2025 Feb; 537:113824.
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Li Y, Saba L, Scheinman RI, Banda NK, Holers M, Monte A, Dylla L, Moghimi SM, Simberg D. Nanoparticle-Binding Immunoglobulins Predict Variable Complement Responses in Healthy and Diseased Cohorts. ACS Nano. 2024 10 22; 18(42):28649-28658.
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Mickael C, Jordan M, Posey JN, Tuder RM, Nozik ES, Thurman JM, Stenmark KR, Graham BB, Delaney CA. Activation of platelets and the complement system in mice with Schistosoma-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2024 Nov 01; 327(5):L661-L668.
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Vivarelli M, Barratt J, Beck LH, Fakhouri F, Gale DP, Goicoechea de Jorge E, Mosca M, Noris M, Pickering MC, Susztak K, Thurman JM, Cheung M, King JM, Jadoul M, Winkelmayer WC, Smith RJH. The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2024 Sep; 106(3):369-391.
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Li Y, Monte A, Dylla L, Moghimi SM, Simberg D. Validation of dot blot immunoassay for measurement of complement opsonization of nanoparticles. J Immunol Methods. 2024 05; 528:113668.
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Liu F, Ryan ST, Fahnoe KC, Morgan JG, Cheung AE, Storek MJ, Best A, Chen HA, Locatelli M, Xu S, Schmidt E, Schmidt-Jim?nez LF, Bieber K, Henderson JM, Lian CG, Verschoor A, Ludwig RJ, Benigni A, Remuzzi G, Salant DJ, Kalled SL, Thurman JM, Holers VM, Violette SM, Wawersik S. C3d-Targeted factor H inhibits tissue complement in disease models and reduces glomerular injury without affecting circulating complement. Mol Ther. 2024 Apr 03; 32(4):1061-1079.
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Haroon HB, Dhillon E, Farhangrazi ZS, Trohopoulos PN, Simberg D, Moghimi SM. Activation of the complement system by nanoparticles and strategies for complement inhibition. Eur J Pharm Biopharm. 2023 Dec; 193:227-240.
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