 Complement Activation
"Complement Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The sequential activation of serum COMPLEMENT PROTEINS to create the COMPLEMENT MEMBRANE ATTACK COMPLEX. Factors initiating complement activation include ANTIGEN-ANTIBODY COMPLEXES, microbial ANTIGENS, or cell surface POLYSACCHARIDES.
| Descriptor ID |
D003167
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| MeSH Number(s) |
G12.274
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| Concept/Terms |
Complement Activation- Complement Activation
- Activation, Complement
- Activations, Complement
- Complement Activations
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Below are MeSH descriptors whose meaning is more general than "Complement Activation".
Below are MeSH descriptors whose meaning is more specific than "Complement Activation".
This graph shows the total number of publications written about "Complement Activation" by people in this website by year, and whether "Complement Activation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 2 | 3 | | 1994 | 1 | 1 | 2 | | 1995 | 1 | 2 | 3 | | 1996 | 0 | 3 | 3 | | 1997 | 1 | 0 | 1 | | 1998 | 1 | 1 | 2 | | 1999 | 0 | 2 | 2 | | 2000 | 2 | 1 | 3 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2003 | 6 | 0 | 6 | | 2004 | 1 | 3 | 4 | | 2005 | 1 | 1 | 2 | | 2006 | 3 | 5 | 8 | | 2007 | 1 | 3 | 4 | | 2008 | 3 | 1 | 4 | | 2010 | 3 | 3 | 6 | | 2011 | 3 | 3 | 6 | | 2012 | 2 | 3 | 5 | | 2013 | 4 | 6 | 10 | | 2014 | 5 | 4 | 9 | | 2015 | 3 | 2 | 5 | | 2016 | 8 | 5 | 13 | | 2017 | 6 | 3 | 9 | | 2018 | 6 | 8 | 14 | | 2019 | 7 | 6 | 13 | | 2020 | 9 | 6 | 15 | | 2021 | 3 | 5 | 8 | | 2022 | 3 | 9 | 12 | | 2023 | 1 | 2 | 3 |
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Below are the most recent publications written about "Complement Activation" by people in Profiles.
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Holers VM. Complement therapeutics are coming of age in rheumatology. Nat Rev Rheumatol. 2023 08; 19(8):470-485.
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Holers VM, Frank RM, Clauw A, Seifert J, Zuscik M, Asokan S, Striebich C, Clay MR, Moreland LW, Banda NK. Potential causal role of synovial complement system activation in the development of post-traumatic osteoarthritis after anterior cruciate ligament injury or meniscus tear. Front Immunol. 2023; 14:1146563.
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Kemper C, Ferreira VP, Paz JT, Holers VM, Lionakis MS, Alexander JJ. Complement: The Road Less Traveled. J Immunol. 2023 01 15; 210(2):119-125.
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Harrison RA, Harris CL, Thurman JM. The complement alternative pathway in health and disease-activation or amplification? Immunol Rev. 2023 01; 313(1):6-14.
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Thurman JM, Fremeaux-Bacchi V. Alternative pathway diagnostics. Immunol Rev. 2023 01; 313(1):225-238.
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Stenson EK, Kendrick J, Dixon B, Thurman JM. The complement system in pediatric acute kidney injury. Pediatr Nephrol. 2023 05; 38(5):1411-1425.
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Moghimi SM, Haroon HB, Yaghmur A, Simberg D, Trohopoulos PN. Nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles. J Control Release. 2022 11; 351:432-443.
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Holers VM. Contributions of animal models to mechanistic understandings of antibody-dependent disease and roles of the amplification loop. Immunol Rev. 2023 01; 313(1):181-193.
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Renner B, Laskowski J, Poppelaars F, Ferreira VP, Blaine J, Antonioli AH, Hannan JP, Kovacs JM, van Kooten C, You Z, Pickering MC, Holers VM, Thurman JM. Factor H related proteins modulate complement activation on kidney cells. Kidney Int. 2022 Dec; 102(6):1331-1344.
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Kalluri SR, Srivastava R, Kenet S, Tanti GK, Dornmair K, Bennett JL, Misgeld T, Hemmer B, Wyss MT, Herwerth M. P2R Inhibitors Prevent Antibody-Mediated Complement Activation in an Animal Model of Neuromyelitis Optica : P2R Inhibitors Prevent Autoantibody Injury. Neurotherapeutics. 2022 09; 19(5):1603-1616.
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