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Nedd4 Ubiquitin Protein Ligases

"Nedd4 Ubiquitin Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.


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This graph shows the total number of publications written about "Nedd4 Ubiquitin Protein Ligases" by people in this website by year, and whether "Nedd4 Ubiquitin Protein Ligases" was a major or minor topic of these publications.
Bar chart showing 6 publications over 4 distinct years, with a maximum of 3 publications in 2015
To see the data from this visualization as text, click here.

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