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David J Barton

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/724-4215

    Collapse Research 
    Collapse research activities and funding
    R21AI042189     (BARTON, DAVID J)Sep 15, 2003 - Aug 31, 2004
    NIH
    Enterovirus RNA Translation and Replication
    Role: Principal Investigator
    R01AI042189     (BARTON, DAVID J)Jul 1, 1998 - May 31, 2025
    NIH
    Enterovirus RNA Replication and Recombination
    Role: Principal Investigator
    R56AI042189     (BARTON, DAVID J)Jul 1, 1998 - Apr 30, 2010
    NIH
    Enterovirus RNA Translation and Replication
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Trautman WJ, Ahmed F, Barton DJ, Abesamis MG, Lynch MJ. Safe administration of Crotalidae equine immune F(ab')2 antivenom in a patient who suffered anaphylaxis from Crotalidae polyvalent immune Fab antivenom. Am J Emerg Med. 2023 10; 72:221.e1-221.e3. PMID: 37648591.
      View in: PubMed
    2. Barton DJ, Coppler PJ, Talia NN, Charalambides A, Stancil B, Puccio AM, Okonkwo DO, Callaway CW, Guyette FX, Elmer J. Prehospital Electroencephalography to Detect Traumatic Brain Injury during Helicopter Transport: A Pilot Observational Cohort Study. Prehosp Emerg Care. 2024; 28(2):405-412. PMID: 36857200.
      View in: PubMed
    3. Barton DJ, Kumar RG, Schuster AA, Juengst SB, Oh BM, Wagner AK. Acute Cortisol Profile Associations With Cognitive Impairment After Severe Traumatic Brain Injury. Neurorehabil Neural Repair. 2021 12; 35(12):1088-1099. PMID: 34689657.
      View in: PubMed
    4. Ancar R, Li Y, Kindler E, Cooper DA, Ransom M, Thiel V, Weiss SR, Hesselberth JR, Barton DJ. Physiologic RNA targets and refined sequence specificity of coronavirus EndoU. RNA. 2020 12; 26(12):1976-1999. PMID: 32989044.
      View in: PubMed
    5. Kempf BJ, Watkins CL, Peersen OB, Barton DJ. An Extended Primer Grip of Picornavirus Polymerase Facilitates Sexual RNA Replication Mechanisms. J Virol. 2020 07 30; 94(16). PMID: 32522851.
      View in: PubMed
    6. Watkins CL, Kempf BJ, Beaucourt S, Barton DJ, Peersen OB. Picornaviral polymerase domain exchanges reveal a modular basis for distinct biochemical activities of viral RNA-dependent RNA polymerases. J Biol Chem. 2020 07 31; 295(31):10624-10637. PMID: 32493771.
      View in: PubMed
    7. Vijapur SM, Yang Z, Barton DJ, Vaughan L, Awan N, Kumar RG, Oh BM, Berga SL, Wang KK, Wagner AK. Anti-Pituitary and Anti-Hypothalamus Autoantibody Associations with Inflammation and Persistent Hypogonadotropic Hypogonadism in Men with Traumatic Brain Injury. J Neurotrauma. 2020 07 15; 37(14):1609-1626. PMID: 32111134.
      View in: PubMed
    8. Kempf BJ, Watkins CL, Peersen OB, Barton DJ. Picornavirus RNA Recombination Counteracts Error Catastrophe. J Virol. 2019 07 15; 93(14). PMID: 31068422.
      View in: PubMed
    9. Barton DJ, Shao S, Marino RT, Reichmeider A, Yanta JH, Pizon AF. Neurotoxic envenomation by the South African coral snake (Aspidelaps lubricus): A case report. Toxicon. 2019 Mar 01; 159:38-40. PMID: 30660557.
      View in: PubMed
    10. Barton DJ, Marino RT, Pizon AF. Multimodal analgesia in crotalid snakebite envenomation: A novel use of femoral nerve block. Am J Emerg Med. 2018 12; 36(12):2340.e1-2340.e2. PMID: 30224272.
      View in: PubMed
    11. Main BS, Villapol S, Sloley SS, Barton DJ, Parsadanian M, Agbaegbu C, Stefos K, McCann MS, Washington PM, Rodriguez OC, Burns MP. Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury. Mol Neurodegener. 2018 04 04; 13(1):17. PMID: 29618365.
      View in: PubMed
    12. Kempf BJ, Peersen OB, Barton DJ. Poliovirus Polymerase Leu420 Facilitates RNA Recombination and Ribavirin Resistance. J Virol. 2016 10 01; 90(19):8410-21. PMID: 27412593.
      View in: PubMed
    13. Barton DJ, Kumar RG, McCullough EH, Galang G, Arenth PM, Berga SL, Wagner AK. Persistent Hypogonadotropic Hypogonadism in Men After Severe Traumatic Brain Injury: Temporal Hormone Profiles and Outcome Prediction. J Head Trauma Rehabil. 2016 Jul-Aug; 31(4):277-87. PMID: 26360007.
      View in: PubMed
    14. Winston CN, No?l A, Neustadtl A, Parsadanian M, Barton DJ, Chellappa D, Wilkins TE, Alikhani AD, Zapple DN, Villapol S, Planel E, Burns MP. Dendritic Spine Loss and Chronic White Matter Inflammation in a Mouse Model of Highly Repetitive Head Trauma. Am J Pathol. 2016 Mar; 186(3):552-67. PMID: 26857506.
      View in: PubMed
    15. Barton DJ, Tift FW, Cournoyer LE, Vieth JT, Hudson KB. Acute Alcohol Use and Injury Patterns in Young Adult Prehospital Patients. Prehosp Emerg Care. 2016; 20(2):206-11. PMID: 27002348.
      View in: PubMed
    16. Kempf BJ, Barton DJ. Picornavirus RNA polyadenylation by 3D(pol), the viral RNA-dependent RNA polymerase. Virus Res. 2015 Aug 03; 206:3-11. PMID: 25559071.
      View in: PubMed
    17. Cooper DA, Banerjee S, Chakrabarti A, Garc?a-Sastre A, Hesselberth JR, Silverman RH, Barton DJ. RNase L targets distinct sites in influenza A virus RNAs. J Virol. 2015 Mar; 89(5):2764-76. PMID: 25540362.
      View in: PubMed
    18. Cooper DA, Jha BK, Silverman RH, Hesselberth JR, Barton DJ. Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs. Nucleic Acids Res. 2014 Apr; 42(8):5202-16. PMID: 24500209.
      View in: PubMed
    19. Winston CN, Chellappa D, Wilkins T, Barton DJ, Washington PM, Loane DJ, Zapple DN, Burns MP. Controlled cortical impact results in an extensive loss of dendritic spines that is not mediated by injury-induced amyloid-beta accumulation. J Neurotrauma. 2013 Dec 01; 30(23):1966-72. PMID: 23879560.
      View in: PubMed
    20. Kempf BJ, Kelly MM, Springer CL, Peersen OB, Barton DJ. Structural features of a picornavirus polymerase involved in the polyadenylation of viral RNA. J Virol. 2013 May; 87(10):5629-44. PMID: 23468507.
      View in: PubMed
    21. Katzer R, Barton DJ, Adelman S, Clark S, Seaman EL, Hudson KB. Impact of implementing an EMR on physical exam documentation by ambulance personnel. Appl Clin Inform. 2012; 3(3):301-8. PMID: 23646077.
      View in: PubMed
    22. Schuessler A, Funk A, Lazear HM, Cooper DA, Torres S, Daffis S, Jha BK, Kumagai Y, Takeuchi O, Hertzog P, Silverman R, Akira S, Barton DJ, Diamond MS, Khromykh AA. West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response. J Virol. 2012 May; 86(10):5708-18. PMID: 22379089.
      View in: PubMed
    23. Kortus MG, Kempf BJ, Haworth KG, Barton DJ, Peersen OB. A template RNA entry channel in the fingers domain of the poliovirus polymerase. J Mol Biol. 2012 Apr 06; 417(4):263-78. PMID: 22321798.
      View in: PubMed
    24. Shimakami T, Yamane D, Jangra RK, Kempf BJ, Spaniel C, Barton DJ, Lemon SM. Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):941-6. PMID: 22215596.
      View in: PubMed
    25. Malathi K, Saito T, Crochet N, Barton DJ, Gale M, Silverman RH. RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP. RNA. 2010 Nov; 16(11):2108-19. PMID: 20833746.
      View in: PubMed
    26. Hobdey SE, Kempf BJ, Steil BP, Barton DJ, Peersen OB. Poliovirus polymerase residue 5 plays a critical role in elongation complex stability. J Virol. 2010 Aug; 84(16):8072-84. PMID: 20534858.
      View in: PubMed
    27. Steil BP, Kempf BJ, Barton DJ. Poly(A) at the 3' end of positive-strand RNA and VPg-linked poly(U) at the 5' end of negative-strand RNA are reciprocal templates during replication of poliovirus RNA. J Virol. 2010 Mar; 84(6):2843-58. PMID: 20071574.
      View in: PubMed
    28. Steil BP, Barton DJ. Conversion of VPg into VPgpUpUOH before and during poliovirus negative-strand RNA synthesis. J Virol. 2009 Dec; 83(24):12660-70. PMID: 19812161.
      View in: PubMed
    29. Townsend HL, Jha BK, Silverman RH, Barton DJ. A putative loop E motif and an H-H kissing loop interaction are conserved and functional features in a group C enterovirus RNA that inhibits ribonuclease L. RNA Biol. 2008 Oct-Dec; 5(4):263-72. PMID: 19088502.
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    30. Steil BP, Barton DJ. Cis-active RNA elements (CREs) and picornavirus RNA replication. Virus Res. 2009 Feb; 139(2):240-52. PMID: 18773930.
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    31. Steil BP, Barton DJ. Poliovirus cis-acting replication element-dependent VPg Uridylylation lowers the Km of the initiating nucleoside triphosphate for viral RNA replication. J Virol. 2008 Oct; 82(19):9400-8. PMID: 18653453.
      View in: PubMed
    32. Owrutsky JC, Pomfret MB, Barton DJ, Kidwell DA. Fourier transform infrared spectroscopy of azide and cyanate ion pairs in AOT reverse micelles. J Chem Phys. 2008 Jul 14; 129(2):024513. PMID: 18624544.
      View in: PubMed
    33. Townsend HL, Jha BK, Han JQ, Maluf NK, Silverman RH, Barton DJ. A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L. RNA. 2008 Jun; 14(6):1026-36. PMID: 18426919.
      View in: PubMed
    34. Kempf BJ, Barton DJ. Poly(rC) binding proteins and the 5' cloverleaf of uncapped poliovirus mRNA function during de novo assembly of polysomes. J Virol. 2008 Jun; 82(12):5835-46. PMID: 18400854.
      View in: PubMed
    35. Kempf BJ, Barton DJ. Poliovirus 2A(Pro) increases viral mRNA and polysome stability coordinately in time with cleavage of eIF4G. J Virol. 2008 Jun; 82(12):5847-59. PMID: 18400852.
      View in: PubMed
    36. Washenberger CL, Han JQ, Kechris KJ, Jha BK, Silverman RH, Barton DJ. Hepatitis C virus RNA: dinucleotide frequencies and cleavage by RNase L. Virus Res. 2007 Dec; 130(1-2):85-95. PMID: 17604869.
      View in: PubMed
    37. Han JQ, Townsend HL, Jha BK, Paranjape JM, Silverman RH, Barton DJ. A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L. J Virol. 2007 Jun; 81(11):5561-72. PMID: 17344297.
      View in: PubMed
    38. Jurgens CK, Barton DJ, Sharma N, Morasco BJ, Ogram SA, Flanegan JB. 2Apro is a multifunctional protein that regulates the stability, translation and replication of poliovirus RNA. Virology. 2006 Feb 20; 345(2):346-57. PMID: 16297952.
      View in: PubMed
    39. Han JQ, Wroblewski G, Xu Z, Silverman RH, Barton DJ. Sensitivity of hepatitis C virus RNA to the antiviral enzyme ribonuclease L is determined by a subset of efficient cleavage sites. J Interferon Cytokine Res. 2004 Nov; 24(11):664-76. PMID: 15684820.
      View in: PubMed
    40. Murray KE, Steil BP, Roberts AW, Barton DJ. Replication of poliovirus RNA with complete internal ribosome entry site deletions. J Virol. 2004 Feb; 78(3):1393-402. PMID: 14722294.
      View in: PubMed
    41. Murray KE, Barton DJ. Poliovirus CRE-dependent VPg uridylylation is required for positive-strand RNA synthesis but not for negative-strand RNA synthesis. J Virol. 2003 Apr; 77(8):4739-50. PMID: 12663781.
      View in: PubMed
    42. Pathak HB, Ghosh SK, Roberts AW, Sharma SD, Yoder JD, Arnold JJ, Gohara DW, Barton DJ, Paul AV, Cameron CE. Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol). A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation. J Biol Chem. 2002 Aug 30; 277(35):31551-62. PMID: 12077141.
      View in: PubMed
    43. Han JQ, Barton DJ. Activation and evasion of the antiviral 2'-5' oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA. RNA. 2002 Apr; 8(4):512-25. PMID: 11991644.
      View in: PubMed
    44. Lyons T, Murray KE, Roberts AW, Barton DJ. Poliovirus 5'-terminal cloverleaf RNA is required in cis for VPg uridylylation and the initiation of negative-strand RNA synthesis. J Virol. 2001 Nov; 75(22):10696-708. PMID: 11602711.
      View in: PubMed
    45. Barton DJ, O'Donnell BJ, Flanegan JB. 5' cloverleaf in poliovirus RNA is a cis-acting replication element required for negative-strand synthesis. EMBO J. 2001 Mar 15; 20(6):1439-48. PMID: 11250909.
      View in: PubMed
    46. Barton DJ, Morasco BJ, Flanegan JB. Translating ribosomes inhibit poliovirus negative-strand RNA synthesis. J Virol. 1999 Dec; 73(12):10104-12. PMID: 10559325.
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    47. Barton DJ, Flanegan JB. Synchronous replication of poliovirus RNA: initiation of negative-strand RNA synthesis requires the guanidine-inhibited activity of protein 2C. J Virol. 1997 Nov; 71(11):8482-9. PMID: 9343205.
      View in: PubMed
    48. Tang RS, Barton DJ, Flanegan JB, Kirkegaard K. Poliovirus RNA recombination in cell-free extracts. RNA. 1997 Jun; 3(6):624-33. PMID: 9174097.
      View in: PubMed
    49. Barton DJ, Morasco BJ, Eisner-Smerage L, Collis PS, Diamond SE, Hewlett MJ, Merchant MA, O'Donnell BJ, Flanegan JB. Poliovirus RNA polymerase mutation 3D-M394T results in a temperature-sensitive defect in RNA synthesis. Virology. 1996 Mar 15; 217(2):459-69. PMID: 8610437.
      View in: PubMed
    50. Barton DJ, Morasco BJ, Flanegan JB. Assays for poliovirus polymerase, 3D(Pol), and authentic RNA replication in HeLa S10 extracts. Methods Enzymol. 1996; 275:35-57. PMID: 9026649.
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    51. Barton DJ, Black EP, Flanegan JB. Complete replication of poliovirus in vitro: preinitiation RNA replication complexes require soluble cellular factors for the synthesis of VPg-linked RNA. J Virol. 1995 Sep; 69(9):5516-27. PMID: 7636997.
      View in: PubMed
    52. Barton DJ, Flanegan JB. Coupled translation and replication of poliovirus RNA in vitro: synthesis of functional 3D polymerase and infectious virus. J Virol. 1993 Feb; 67(2):822-31. PMID: 8380467.
      View in: PubMed
    53. Collis PS, O'Donnell BJ, Barton DJ, Rogers JA, Flanegan JB. Replication of poliovirus RNA and subgenomic RNA transcripts in transfected cells. J Virol. 1992 Nov; 66(11):6480-8. PMID: 1328676.
      View in: PubMed
    54. Phair IC, Barton DJ, Allen MJ, Barnes MR. Preventable deaths after head injury: a clinical audit of performance. Injury. 1991 Sep; 22(5):353-6. PMID: 1806492.
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    55. Barton DJ, Sawicki SG, Sawicki DL. Solubilization and immunoprecipitation of alphavirus replication complexes. J Virol. 1991 Mar; 65(3):1496-506. PMID: 1847467.
      View in: PubMed
    56. Phair IC, Barton DJ, Barnes MR, Allen MJ. Deaths following trauma: an audit of performance. Ann R Coll Surg Engl. 1991 Jan; 73(1):53-7. PMID: 1996865.
      View in: PubMed
    57. Barton DJ, Sawicki SG, Sawicki DL. Demonstration in vitro of temperature-sensitive elongation of RNA in Sindbis virus mutant ts6. J Virol. 1988 Oct; 62(10):3597-602. PMID: 3418782.
      View in: PubMed
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