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Jennifer N Cha

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentChemical & Biological Engin
Phone303/735-6735
    Other Positions
    TitleEndowed or Named Professor
    InstitutionUniversity of Colorado Boulder
    DepartmentCollege Engineering & App Sci


    Collapse Research 
    Collapse research activities and funding
    R21AR078506     (CHA, JENNIFER N ;GOODWIN, ANDREW P)Jan 13, 2021 - Dec 31, 2022
    NIH
    Controllable 2- and 3D Assembly of Mechanically Robust Skin Tissue Via Long Term Expression of DNA on Cell Membranes
    Role: Principal Investigator
    R21GM135668     (GOODWIN, ANDREW P)Jan 1, 2020 - Dec 31, 2021
    NIH
    Affinity-Mediated Covalent Conjugation: A Method for Direct Modification of Specific Receptors on Cell Membranes
    Role: Co-Principal Investigator
    R21EB027319     (GOODWIN, ANDREW P)Jan 1, 2019 - May 31, 2021
    NIH
    Nonlinear Photoacoustic Response from Functionalized Gold and Metal Oxide Nanostructures
    Role: Co-Principal Investigator
    R21EB020911     (CHA, JENNIFER N)Jul 1, 2015 - Apr 30, 2018
    NIH
    Biomolecule-Directed Assembly for Enhancing Near IR Energy Transfer Processes in Theranostics
    Role: Principal Investigator
    R21EB012758     (ESENER, SADIK)Jul 15, 2011 - Jun 30, 2013
    NIH
    Stimulus-Responsive Microbubbles for Site-Specific Imaging of Thrombosis
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Saemundsson SA, Ganguly S, Curry SD, Goodwin AP, Cha JN. Controlling Cell Organization in 3D Coculture Spheroids Using DNA Interactions. ACS Biomater Sci Eng. 2023 06 12; 9(6):3185-3192. PMID: 37155244.
      View in: PubMed
    2. Mueller EN, Alina TB, Curry SD, Ganguly S, Cha JN, Goodwin AP. Silica-coated gold nanorods with hydrophobic modification show both enhanced two-photon fluorescence and ultrasound drug release. J Mater Chem B. 2022 Dec 07; 10(47):9789-9793. PMID: 36420680.
      View in: PubMed
    3. Roy S, Curry SD, Corbella Bagot C, Mueller EN, Mansouri AM, Park W, Cha JN, Goodwin AP. Enzyme Prodrug Therapy with Photo-Cross-Linkable Anti-EGFR Affibodies Conjugated to Upconverting Nanoparticles. ACS Nano. 2022 10 25; 16(10):15873-15883. PMID: 36129781.
      View in: PubMed
    4. Ganguly S, Roy S, Goodwin AP, Cha JN. Generation of 3D cellular spheroids using DNA modified cell receptors and programmable DNA interactions. Biomater Sci. 2021 Nov 23; 9(23):7911-7920. PMID: 34694305.
      View in: PubMed
    5. Mueller EN, Kuriakose M, Ganguly S, Ma K, Inzunza-Ibarra MA, Murray TW, Cha JN, Goodwin AP. Hydrophobically Modified Silica-Coated Gold Nanorods for Generating Nonlinear Photoacoustic Signals. ACS Appl Nano Mater. 2021 Nov 26; 4(11):12073-12082. PMID: 38031593.
      View in: PubMed
    6. Roy S, Curry SD, Bibbey MG, Chapnick DA, Liu X, Goodwin AP, Cha JN. Effect of covalent photoconjugation of affibodies to epidermal growth factor receptor (EGFR) on cellular quiescence. Biotechnol Bioeng. 2022 01; 119(1):187-198. PMID: 34676884.
      View in: PubMed
    7. Harris AW, Roy S, Ganguly S, Parameswar AV, Lucas FWS, Holewinski A, Goodwin AP, Cha JN. Investigating the use of conducting oligomers and redox molecules in CdS-MoFeP biohybrids. Nanoscale Adv. 2021 Mar 09; 3(5):1392-1396. PMID: 36132854.
      View in: PubMed
    8. Roy S, Cha JN, Goodwin AP. Nongenetic Bioconjugation Strategies for Modifying Cell Membranes and Membrane Proteins: A Review. Bioconjug Chem. 2020 11 18; 31(11):2465-2475. PMID: 33146010.
      View in: PubMed
    9. Harguindey A, Culver HR, Sinha J, Bowman CN, Cha JN. Efficient cellular uptake of click nucleic acid modified proteins. Chem Commun (Camb). 2020 May 02; 56(35):4820-4823. PMID: 32236172.
      View in: PubMed
    10. Harris AW, Harguindey A, Patalano RE, Roy S, Yehezkeli O, Goodwin AP, Cha JN. Investigating Protein-Nanocrystal Interactions for Photodriven Activity. ACS Appl Bio Mater. 2020 Feb 17; 3(2):1026-1035. PMID: 35019304.
      View in: PubMed
    11. Roy S, Brasino M, Beirne JM, Harguindey A, Chapnick DA, Liu X, Cha JN, Goodwin AP. Enzymes Photo-Cross-Linked to Live Cell Receptors Retain Activity and EGFR Inhibition after Both Internalization and Recycling. Bioconjug Chem. 2020 01 15; 31(1):104-112. PMID: 31840981.
      View in: PubMed
    12. Hafenstine GR, Patalano RE, Harris AW, Jiang G, Ma K, Goodwin AP, Cha JN. Solar Photocatalytic Phenol Polymerization and Hydrogen Generation for Flocculation of Wastewater Impurities. ACS Appl Polym Mater. 2019 Jun 14; 1(6):1451-1457. PMID: 37206614.
      View in: PubMed
    13. Bull DS, Kienle DF, Chaparro Sosa AF, Nelson N, Roy S, Cha JN, Schwartz DK, Kaar JL, Goodwin AP. Surface-Templated Nanobubbles Protect Proteins from Surface-Mediated Denaturation. J Phys Chem Lett. 2019 Jun 06; 10(11):2641-2647. PMID: 31067058.
      View in: PubMed
    14. Harguindey A, Roy S, Harris AW, Fairbanks BD, Goodwin AP, Bowman CN, Cha JN. Click Nucleic Acid Mediated Loading of Prodrug Activating Enzymes in PEG-PLGA Nanoparticles for Combination Chemotherapy. Biomacromolecules. 2019 04 08; 20(4):1683-1690. PMID: 30884222.
      View in: PubMed
    15. Yildirim A, Shi D, Roy S, Blum NT, Chattaraj R, Cha JN, Goodwin AP. Nanoparticle-Mediated Acoustic Cavitation Enables High Intensity Focused Ultrasound Ablation Without Tissue Heating. ACS Appl Mater Interfaces. 2018 Oct 31; 10(43):36786-36795. PMID: 30339360.
      View in: PubMed
    16. Han X, Domaille DW, Fairbanks BD, He L, Culver HR, Zhang X, Cha JN, Bowman CN. New Generation of Clickable Nucleic Acids: Synthesis and Active Hybridization with DNA. Biomacromolecules. 2018 10 08; 19(10):4139-4146. PMID: 30212619.
      View in: PubMed
    17. Brasino M, Roy S, Erbse AH, He L, Mao C, Park W, Cha JN, Goodwin AP. Anti-EGFR Affibodies with Site-Specific Photo-Cross-Linker Incorporation Show Both Directed Target-Specific Photoconjugation and Increased Retention in Tumors. J Am Chem Soc. 2018 09 19; 140(37):11820-11828. PMID: 30203972.
      View in: PubMed
    18. He L, Mao C, Brasino M, Harguindey A, Park W, Goodwin AP, Cha JN. TiO2-Capped Gold Nanorods for Plasmon-Enhanced Production of Reactive Oxygen Species and Photothermal Delivery of Chemotherapeutic Agents. ACS Appl Mater Interfaces. 2018 Aug 22; 10(33):27965-27971. PMID: 30044085.
      View in: PubMed
    19. Hafenstine GR, Harris AW, Ma K, Cha JN, Goodwin AP. Conversion of Ethanol to 2-Ethylhexenal at Ambient Conditions Using Tandem, Biphasic Catalysis. ACS Sustain Chem Eng. 2017; 5(11):10483-10489. PMID: 33224638.
      View in: PubMed
    20. Liu Z, Fairbanks B, He L, Liu T, Shah P, Cha JN, Stansbury JW, Bowman CN. Water-soluble clickable nucleic acid (CNA) polymer synthesis by functionalizing the pendant hydroxyl. Chem Commun (Camb). 2017 Sep 12; 53(73):10156-10159. PMID: 28849813.
      View in: PubMed
    21. Harris AW, Yehezkeli O, Hafenstine GR, Goodwin AP, Cha JN. Light-Driven Catalytic Upgrading of Butanol in a Biohybrid Photoelectrochemical System. ACS Sustain Chem Eng. 2017; 5(9):8199-8204. PMID: 33133786.
      View in: PubMed
    22. He L, Brasino M, Mao C, Cho S, Park W, Goodwin AP, Cha JN. DNA-Assembled Core-Satellite Upconverting-Metal-Organic Framework Nanoparticle Superstructures for Efficient Photodynamic Therapy. Small. 2017 06; 13(24). PMID: 28481463.
      View in: PubMed
    23. Harguindey A, Domaille DW, Fairbanks BD, Wagner J, Bowman CN, Cha JN. Synthesis and Assembly of Click-Nucleic-Acid-Containing PEG-PLGA Nanoparticles for DNA Delivery. Adv Mater. 2017 Jun; 29(24). PMID: 28397966.
      View in: PubMed
    24. Okochi KD, Monfregola L, Dickerson SM, McCaffrey R, Domaille DW, Yu C, Hafenstine GR, Jin Y, Cha JN, Kuchta RD, Caruthers M, Zhang W. Synthesis of Small-Molecule/DNA Hybrids through On-Bead Amide-Coupling Approach. J Org Chem. 2017 10 20; 82(20):10803-10811. PMID: 28282138.
      View in: PubMed
    25. Brasino M, Cha JN. Real-time femtomolar detection of cancer biomarkers from photoconjugated antibody-phage constructs. Analyst. 2016 12 19; 142(1):91-97. PMID: 27731431.
      View in: PubMed
    26. Hafenstine GR, Ma K, Harris AW, Yehezkeli O, Park E, Domaille DW, Cha JN, Goodwin AP. Multicatalytic, Light-Driven Upgrading of Butanol to 2-Ethylhexenal and Hydrogen under Mild Aqueous Conditions. ACS Catal. 2017; 7(1):568-572. PMID: 33133753.
      View in: PubMed
    27. Yehezkeli O, Bedford NM, Park E, Ma K, Cha JN. Semiconductor-Based, Solar-Driven Photochemical Cells for Fuel Generation from Carbon Dioxide in Aqueous Solutions. ChemSusChem. 2016 11 23; 9(22):3188-3195. PMID: 27775240.
      View in: PubMed
    28. He L, Dragavon J, Cho S, Mao C, Yildirim A, Ma K, Chattaraj R, Goodwin AP, Park W, Cha JN. Self-assembled gold nanostar-NaYF4:Yb/Er clusters for multimodal imaging, photothermal and photodynamic therapy. J Mater Chem B. 2016 Jul 07; 4(25):4455-4461. PMID: 32263428.
      View in: PubMed
    29. Domaille DW, Hafenstine GR, Greer MA, Goodwin AP, Cha JN. Catalytic Upgrading in Bacteria-Compatible Conditions via a Biocompatible Aldol Condensation. ACS Sustain Chem Eng. 2016 Mar 07; 4(3):671-675. PMID: 28480149.
      View in: PubMed
    30. He L, Mao C, Cho S, Ma K, Xi W, Bowman CN, Park W, Cha JN. Experimental and theoretical photoluminescence studies in nucleic acid assembled gold-upconverting nanoparticle clusters. Nanoscale. 2015 Nov 07; 7(41):17254-60. PMID: 26427014.
      View in: PubMed
    31. Brasino MD, Cha JN. Isothermal rolling circle amplification of virus genomes for rapid antigen detection and typing. Analyst. 2015 Aug 07; 140(15):5138-44. PMID: 26040578.
      View in: PubMed
    32. Ma K, Yehezkeli O, Domaille DW, Funke HH, Cha JN. Enhanced Hydrogen Production from DNA-Assembled Z-Scheme TiO2-CdS Photocatalyst Systems. Angew Chem Int Ed Engl. 2015 Sep 21; 54(39):11490-4. PMID: 26136433.
      View in: PubMed
    33. Brasino M, Lee JH, Cha JN. Creating highly amplified enzyme-linked immunosorbent assay signals from genetically engineered bacteriophage. Anal Biochem. 2015 Feb 01; 470:7-13. PMID: 25447463.
      View in: PubMed
    34. Yehezkeli O, de Oliveira DR, Cha JN. Electrostatically assembled CdS-Co3 O4 nanostructures for photo-assisted water oxidation and photocatalytic reduction of dye molecules. Small. 2015 Feb 11; 11(6):668-74. PMID: 25238557.
      View in: PubMed
    35. Kwon S, Chen ZC, Noh H, Lee JH, Liu H, Cha JN, Xiang J. Selective functionalization and loading of biomolecules in crystalline silicon nanotube field-effect-transistors. Nanoscale. 2014 Jul 21; 6(14):7847-52. PMID: 24926535.
      View in: PubMed
    36. Lee JH, Domaille DW, Noh H, Oh T, Choi C, Jin S, Cha JN. High-yielding and photolabile approaches to the covalent attachment of biomolecules to surfaces via hydrazone chemistry. Langmuir. 2014 Jul 22; 30(28):8452-60. PMID: 24972257.
      View in: PubMed
    37. Domaille DW, Cha JN. Aniline-terminated DNA catalyzes rapid DNA-hydrazone formation at physiological pH. Chem Commun (Camb). 2014 Apr 14; 50(29):3831-3. PMID: 24590233.
      View in: PubMed
    38. McKinnon DD, Domaille DW, Cha JN, Anseth KS. Biophysically defined and cytocompatible covalently adaptable networks as viscoelastic 3D cell culture systems. Adv Mater. 2014 Feb 12; 26(6):865-72. PMID: 24127293.
      View in: PubMed
    39. Xu PF, Lee JH, Ma K, Choi C, Jin S, Wang J, Cha JN. Enhanced Raman signals from switchable nanoparticle probes. Chem Commun (Camb). 2013 Oct 11; 49(79):8994-6. PMID: 23963246.
      View in: PubMed
    40. Nakatsuka MA, Barback CV, Fitch KR, Farwell AR, Esener SC, Mattrey RF, Cha JN, Goodwin AP. In vivo ultrasound visualization of non-occlusive blood clots with thrombin-sensitive contrast agents. Biomaterials. 2013 Dec; 34(37):9559-65. PMID: 24034499.
      View in: PubMed
    41. Xu PF, Noh H, Lee JH, Domaille DW, Nakatsuka MA, Goodwin AP, Cha JN. Imparting the unique properties of DNA into complex material architectures and functions. Mater Today (Kidlington). 2013 Jul; 16(7-8):290-296. PMID: 25525408.
      View in: PubMed
    42. Domaille DW, Lee JH, Cha JN. High density DNA loading on the M13 bacteriophage provides access to colorimetric and fluorescent protein microarray biosensors. Chem Commun (Camb). 2013 Feb 28; 49(17):1759-61. PMID: 23340548.
      View in: PubMed
    43. Xu PF, Hung AM, Noh H, Cha JN. Switchable nanodumbbell probes for analyte detection. Small. 2013 Jan 28; 9(2):228-32. PMID: 23042717.
      View in: PubMed
    44. Nakatsuka MA, Mattrey RF, Esener SC, Cha JN, Goodwin AP. Aptamer-crosslinked microbubbles: smart contrast agents for thrombin-activated ultrasound imaging. Adv Mater. 2012 Nov 27; 24(45):6010-6. PMID: 22941789.
      View in: PubMed
    45. Lee JH, Domaille DW, Cha JN. Amplified protein detection and identification through DNA-conjugated M13 bacteriophage. ACS Nano. 2012 Jun 26; 6(6):5621-6. PMID: 22587008.
      View in: PubMed
    46. Hung AM, Oh T, Cha JN. Facile thermal treatment process for assembling vertically aligned semiconductor nanorods in solution. Nanoscale. 2012 Feb 07; 4(3):1016-20. PMID: 22234405.
      View in: PubMed
    47. Nakatsuka MA, Hsu MJ, Esener SC, Cha JN, Goodwin AP. DNA-coated microbubbles with biochemically tunable ultrasound contrast activity. Adv Mater. 2011 Nov 09; 23(42):4908-12. PMID: 21956383.
      View in: PubMed
    48. Hung AM, Konopliv NA, Cha JN. Solvent-based assembly of CdSe nanorods in solution. Langmuir. 2011 Oct 18; 27(20):12322-8. PMID: 21913707.
      View in: PubMed
    49. Noh H, Hung AM, Cha JN. Surface-driven DNA assembly of binary cubic 3D nanocrystal superlattices. Small. 2011 Nov 04; 7(21):3021-5. PMID: 21901831.
      View in: PubMed
    50. Lee JH, Cha JN. Amplified protein detection through visible plasmon shifts in gold nanocrystal solutions from bacteriophage platforms. Anal Chem. 2011 May 01; 83(9):3516-9. PMID: 21480611.
      View in: PubMed
    51. Xu PF, Noh H, Lee JH, Cha JN. DNA mediated assembly of single walled carbon nanotubes: role of DNA linkers and annealing. Phys Chem Chem Phys. 2011 Jun 07; 13(21):10004-8. PMID: 21336403.
      View in: PubMed
    52. Hung AM, Cha JN. Templated assembly of DNA origami gold nanoparticle arrays on lithographically patterned surfaces. Methods Mol Biol. 2011; 749:187-97. PMID: 21674373.
      View in: PubMed
    53. Nakatsuka MA, Lee JH, Nakayama E, Hung AM, Hsu MJ, Mattrey RF, Esener SC, Cha JN, Goodwin AP. Facile One-Pot Synthesis of Polymer-Phospholipid Composite Microbubbles with Enhanced Drug Loading Capacity for Ultrasound-Triggered Therapy. Soft Matter. 2011; 2011(7):1656-1659. PMID: 21799701.
      View in: PubMed
    54. Noh H, Choi C, Hung AM, Jin S, Cha JN. Site-specific patterning of highly ordered nanocrystal superlattices through biomolecular surface confinement. ACS Nano. 2010 Sep 28; 4(9):5076-80. PMID: 20718405.
      View in: PubMed
    55. Hung AM, Noh H, Cha JN. Recent advances in DNA-based directed assembly on surfaces. Nanoscale. 2010 Dec; 2(12):2530-7. PMID: 20835482.
      View in: PubMed
    56. Hung AM, Micheel CM, Bozano LD, Osterbur LW, Wallraff GM, Cha JN. Large-area spatially ordered arrays of gold nanoparticles directed by lithographically confined DNA origami. Nat Nanotechnol. 2010 Feb; 5(2):121-6. PMID: 20023644.
      View in: PubMed
    57. Noh H, Hung AM, Choi C, Lee JH, Kim JY, Jin S, Cha JN. 50 nm DNA nanoarrays generated from uniform oligonucleotide films. ACS Nano. 2009 Aug 25; 3(8):2376-82. PMID: 19601637.
      View in: PubMed
    58. Kershner RJ, Bozano LD, Micheel CM, Hung AM, Fornof AR, Cha JN, Rettner CT, Bersani M, Frommer J, Rothemund PW, Wallraff GM. Placement and orientation of individual DNA shapes on lithographically patterned surfaces. Nat Nanotechnol. 2009 Sep; 4(9):557-61. PMID: 19734926.
      View in: PubMed
    59. Atmaja B, Cha JN, Marshall A, Frank CW. Supramolecular assembly of block copolypeptides with semiconductor nanocrystals. Langmuir. 2009 Jan 20; 25(2):707-15. PMID: 19072205.
      View in: PubMed
    60. Atmaja B, Cha JN, Frank CW. Adsorbed alpha-helical diblock copolypeptides: molecular organization, structural properties, and interactions. Langmuir. 2009 Jan 20; 25(2):865-72. PMID: 19177647.
      View in: PubMed
    61. Galusha JW, Richey LR, Gardner JS, Cha JN, Bartl MH. Discovery of a diamond-based photonic crystal structure in beetle scales. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 May; 77(5 Pt 1):050904. PMID: 18643018.
      View in: PubMed
    62. LaVan DA, Cha JN. Approaches for biological and biomimetic energy conversion. Proc Natl Acad Sci U S A. 2006 Apr 04; 103(14):5251-5. PMID: 16567648.
      View in: PubMed
    63. Gigliotti B, Sakizzie B, Bethune DS, Shelby RM, Cha JN. Sequence-independent helical wrapping of single-walled carbon nanotubes by long genomic DNA. Nano Lett. 2006 Feb; 6(2):159-64. PMID: 16464027.
      View in: PubMed
    64. Magbitang T, Lee VY, Cha JN, Wang HL, Chung WR, Miller RD, Dubois G, Volksen W, Kim HC, Hedrick JL. Oriented nanoporous lamellar organosilicates templated from topologically unsymmetrical dendritic-linear block copolymers. Angew Chem Int Ed Engl. 2005 Nov 25; 44(46):7574-80. PMID: 16247813.
      View in: PubMed
    65. Freer EM, Krupp LE, Hinsberg WD, Rice PM, Hedrick JL, Cha JN, Miller RD, Kim HC. Oriented mesoporous organosilicate thin films. Nano Lett. 2005 Oct; 5(10):2014-8. PMID: 16218729.
      View in: PubMed
    66. Fu A, Micheel CM, Cha J, Chang H, Yang H, Alivisatos AP. Discrete nanostructures of quantum dots/Au with DNA. J Am Chem Soc. 2004 Sep 08; 126(35):10832-3. PMID: 15339154.
      View in: PubMed
    67. Murthy VS, Cha JN, Stucky GD, Wong MS. Charge-driven flocculation of poly(L-lysine)-gold nanoparticle assemblies leading to hollow microspheres. J Am Chem Soc. 2004 Apr 28; 126(16):5292-9. PMID: 15099114.
      View in: PubMed
    68. Cha JN, Birkedal H, Euliss LE, Bartl MH, Wong MS, Deming TJ, Stucky GD. Spontaneous formation of nanoparticle vesicles from homopolymer polyelectrolytes. J Am Chem Soc. 2003 Jul 09; 125(27):8285-9. PMID: 12837100.
      View in: PubMed
    69. Zhou Y, Shimizu K, Cha JN, Stucky GD, Morse DE. Efficient Catalysis of Polysiloxane Synthesis by Silicatein a Requires Specific Hydroxy and Imidazole Functionalities. Angew Chem Int Ed Engl. 1999 Mar 15; 38(6):779-782. PMID: 29711800.
      View in: PubMed
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