 Gene Editing
"Gene Editing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genetic engineering techniques that involve DNA REPAIR mechanisms for incorporating site-specific modifications into a cell's genome.
| Descriptor ID |
D000072669
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| MeSH Number(s) |
E05.393.420.270
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Gene Editing".
Below are MeSH descriptors whose meaning is more specific than "Gene Editing".
This graph shows the total number of publications written about "Gene Editing" by people in this website by year, and whether "Gene Editing" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 3 | 3 | 6 | | 2017 | 4 | 3 | 7 | | 2018 | 4 | 6 | 10 | | 2019 | 1 | 6 | 7 | | 2020 | 4 | 5 | 9 | | 2021 | 3 | 4 | 7 | | 2022 | 0 | 1 | 1 | | 2023 | 1 | 3 | 4 | | 2024 | 4 | 2 | 6 | | 2025 | 2 | 4 | 6 |
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Below are the most recent publications written about "Gene Editing" by people in Profiles.
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Joseph RA, Haley RM, Padilla MS, Ricciardi AS, Yamagata HM, Mitchell MJ. Cas9 Protein Outperforms mRNA in Lipid Nanoparticle-Mediated CFTR Repair. Nano Lett. 2025 Oct 01; 25(39):14348-14355.
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Hren A, Alexander WG, Abraham JP, Tumen-Velasquez MP, Melesse Vergara M, Guss AM, Pfleger BF, Fox JM, Eckert CA. Improving the Transformation Efficiency of Synechococcus sp. PCC 7002 via Methylome-Guided Premethylation of DNA. ACS Synth Biol. 2025 Aug 15; 14(8):3258-3264.
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Liu J, Mosti F, Zhao HT, Lollis D, Sotelo-Fonseca JE, Escobar-Tomlienovich CF, Musso CM, Mao Y, Massri AJ, Doll HM, Moss ND, Sousa AMM, Wray GA, Schmidt ERE, Silver DL. A human-specific enhancer fine-tunes radial glia potency and corticogenesis. Nature. 2025 Jul; 643(8074):1321-1332.
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Haley RM, Padilla MS, El-Mayta RD, Joseph RA, Weber JA, Figueroa-Espada CG, Mukalel AJ, Ricciardi AS, Palanki R, Geisler HC, Jester MT, Davidson BL, Mitchell MJ. Lipid Nanoparticles for In Vivo Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical Targets. ACS Nano. 2025 04 15; 19(14):13790-13804.
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Padilla MS, Mrksich K, Wang Y, Haley RM, Li JJ, Han EL, El-Mayta R, Kim EH, Dias S, Gong N, Teerdhala SV, Han X, Chowdhary V, Xue L, Siddiqui Z, Yamagata HM, Kim D, Yoon IC, Wilson JM, Radhakrishnan R, Mitchell MJ. Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering. Nat Commun. 2025 Jan 24; 16(1):996.
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Cortázar MA, Jagannathan S. SelectRepair Knockout: Efficient PTC-Free Gene Knockout Through Selectable Homology-Directed DNA Repair. Methods Mol Biol. 2025; 2863:397-417.
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Inen J, Han CM, Farrel DM, Bilousova G, Kogut I. CIRCLE-Seq for Interrogation of Off-Target Gene Editing. J Vis Exp. 2024 Nov 01; (213).
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Xue L, Zhao G, Gong N, Han X, Shepherd SJ, Xiong X, Xiao Z, Palanki R, Xu J, Swingle KL, Warzecha CC, El-Mayta R, Chowdhary V, Yoon IC, Xu J, Cui J, Shi Y, Alameh MG, Wang K, Wang L, Pochan DJ, Weissman D, Vaughan AE, Wilson JM, Mitchell MJ. Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery. Nat Nanotechnol. 2025 Jan; 20(1):132-143.
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Palanki R, Han EL, Murray AM, Maganti R, Tang S, Swingle KL, Kim D, Yamagata H, Safford HC, Mrksich K, Peranteau WH, Mitchell MJ. Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing. Lab Chip. 2024 08 06; 24(16):3790-3801.
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Palanki R, Riley JS, Bose SK, Luks V, Dave A, Kus N, White BM, Ricciardi AS, Swingle KL, Xue L, Sung D, Thatte AS, Safford HC, Chaluvadi VS, Carpenter M, Han EL, Maganti R, Hamilton AG, Mrksich K, Billingsley MB, Zoltick PW, Alameh MG, Weissman D, Mitchell MJ, Peranteau WH. In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proc Natl Acad Sci U S A. 2024 Aug 06; 121(32):e2400783121.
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