 Islets of Langerhans
"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
| Descriptor ID |
D007515
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| MeSH Number(s) |
A03.734.414 A06.407.414
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| Concept/Terms |
Islets of Langerhans- Islets of Langerhans
- Langerhans Islets
- Pancreatic Islets
- Islet, Pancreatic
- Islets, Pancreatic
- Pancreatic Islet
- Nesidioblasts
- Nesidioblast
- Pancreas, Endocrine
- Endocrine Pancreas
- Islands of Langerhans
- Langerhans Islands
- Islet Cells
- Cell, Islet
- Cells, Islet
- Islet Cell
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Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".
Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".
This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 4 | 2 | 6 | | 1997 | 3 | 0 | 3 | | 1998 | 5 | 0 | 5 | | 1999 | 4 | 3 | 7 | | 2000 | 8 | 3 | 11 | | 2001 | 2 | 1 | 3 | | 2002 | 2 | 4 | 6 | | 2003 | 11 | 2 | 13 | | 2004 | 10 | 8 | 18 | | 2005 | 8 | 1 | 9 | | 2006 | 6 | 5 | 11 | | 2007 | 8 | 2 | 10 | | 2008 | 10 | 5 | 15 | | 2009 | 9 | 8 | 17 | | 2010 | 6 | 4 | 10 | | 2011 | 8 | 4 | 12 | | 2012 | 6 | 6 | 12 | | 2013 | 8 | 8 | 16 | | 2014 | 13 | 8 | 21 | | 2015 | 11 | 3 | 14 | | 2016 | 9 | 3 | 12 | | 2017 | 12 | 3 | 15 | | 2018 | 16 | 8 | 24 | | 2019 | 12 | 8 | 20 | | 2020 | 9 | 5 | 14 | | 2021 | 21 | 10 | 31 | | 2022 | 16 | 1 | 17 | | 2023 | 17 | 0 | 17 | | 2024 | 8 | 6 | 14 | | 2025 | 10 | 4 | 14 | | 2026 | 2 | 1 | 3 |
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Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.
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Hansen MS, Hill CJ, Sussel L, Wells KL. Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets. Diabetes. 2026 Apr 01; 75(4):606-616.
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Greenbaum CJ, Long SA, Gitelman SE, Gaglia JL, Daniels M, Brusko TM, Lord S, Bundy BN, Krischer JP, Haller MJ, Steck AK, DiMeglio LA, Evans-Molina C, Moran A, Prahalad P, Wilson DM, Russell WE, Sherr JL, Raskin P, Clements MA, Moore WV, Libman I, Wassermann K, von Herrath M, Bergholdt R, Hastrup H, Kobernat SE, Kus AM, Tung LW, Goland RS, Herold KC. Phase I Clinical Trial of Islet Antigen-Specific Plasmid Coexpressing Tolerogenic Proteins Demonstrates Safety in Adults With Type 1 Diabetes. Diabetes. 2026 Mar 01; 75(3):506-518.
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Groegler J, Mangold K, Nicholson K, Dang M, Wenzlau J, Beard KS, Hohenstein A, Powell R, Baker R, Haskins K, Matsuda J, Delong T. Strategic Reduction of Hybrid Insulin Peptide Formation Significantly Delays Diabetes Onset in NOD Mice. Diabetes. 2026 Jan 01; 75(1):115-123.
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Landry LG, Wells KL, Anderson AM, Miller KR, Jones KL, Michels AW, Nakayama M. Quantitative V gene-targeted T cell receptor sequencing as a biomarker in type 1 diabetes. JCI Insight. 2026 Feb 09; 11(3).
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Veijola R, Tamura RN, Clasen JL, Elding Larsson H, Warncke K, Steck AK, Haller MJ, Jonsdottir B, Akolkar B, Hagopian WA, Rewers MJ, She JX, Ziegler AG, Krischer JP, Toppari J. Family history of type 2 diabetes delays development of type 1 diabetes in TEDDY children with islet autoimmunity. Diabetologia. 2026 Mar; 69(3):643-652.
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Koskenniemi JJ, Clasen JL, You L, Parikh HM, Vehik K, Yang J, Uusitalo U, Veijola R, Haller MJ, Ziegler AG, Rewers MJ, Hagopian WA, Akolkar B, Lernmark Å, Toppari J, Larsson HE, Krischer JP, Lynch KF. The Contribution of BMI to a Young Child's Risk of Islet Autoimmunity Is Dependent on HLA-DR4-DQ8 Without HLA-DR3-DQ2. Diabetes Care. 2025 Dec 01; 48(12):2103-2110.
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Johansen CG, Lam K, Farnsworth NL. Stressed ß-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes. Front Endocrinol (Lausanne). 2025; 16:1675043.
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Hu X, Webb-Robertson BM, Parikh HM, Nakayasu ES, Onengut-Gumuscu S, Chen WM, Frazer-Abel A, Metz TO, Rich SS, Rewers MJ, Manichaikul A. Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D. Commun Biol. 2025 Sep 26; 8(1):1366.
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Vanderlinden LA, Wong E, Johnson RK, Carry P, Dong F, Kechris K, Rewers M, Norris JM. DNA Methylation Smoking Scores and Risk of Islet Autoimmunity and Type 1 Diabetes. Diabetes Care. 2025 Sep 01; 48(9):1628-1636.
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Bergman BC, Zemski Berry K, Garfield A, Keller A, Zarini S, Bowen S, McKenna C, Kahn D, Pavelka J, Macias E, Uhlson C, Johnson C, Russ HA, Viesi CH, Seldin M, Liu C, Doliba NM, Schoen J, Rothchild K, Hazel K, Naji A. Human Peripancreatic Adipose Tissue Paracrine Signaling Impacts Insulin Secretion, Blood Flow, and Gene Transcription. J Clin Endocrinol Metab. 2025 Jun 17; 110(7):e2233-e2247.
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