 Islets of Langerhans
"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
| Descriptor ID |
D007515
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| MeSH Number(s) |
A03.734.414 A06.407.414
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| Concept/Terms |
Islets of Langerhans- Islets of Langerhans
- Langerhans Islets
- Pancreatic Islets
- Islet, Pancreatic
- Islets, Pancreatic
- Pancreatic Islet
- Nesidioblasts
- Nesidioblast
- Pancreas, Endocrine
- Endocrine Pancreas
- Islands of Langerhans
- Langerhans Islands
- Islet Cells
- Cell, Islet
- Cells, Islet
- Islet Cell
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Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".
Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".
This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 2 | 0 | 2 | | 1996 | 4 | 2 | 6 | | 1997 | 3 | 0 | 3 | | 1998 | 5 | 0 | 5 | | 1999 | 4 | 3 | 7 | | 2000 | 8 | 3 | 11 | | 2001 | 2 | 1 | 3 | | 2002 | 2 | 4 | 6 | | 2003 | 11 | 2 | 13 | | 2004 | 10 | 8 | 18 | | 2005 | 8 | 1 | 9 | | 2006 | 6 | 5 | 11 | | 2007 | 9 | 2 | 11 | | 2008 | 10 | 5 | 15 | | 2009 | 9 | 8 | 17 | | 2010 | 6 | 4 | 10 | | 2011 | 8 | 4 | 12 | | 2012 | 6 | 6 | 12 | | 2013 | 8 | 8 | 16 | | 2014 | 13 | 8 | 21 | | 2015 | 11 | 3 | 14 | | 2016 | 9 | 3 | 12 | | 2017 | 12 | 3 | 15 | | 2018 | 16 | 8 | 24 | | 2019 | 12 | 8 | 20 | | 2020 | 9 | 5 | 14 | | 2021 | 21 | 10 | 31 | | 2022 | 16 | 1 | 17 | | 2023 | 17 | 0 | 17 | | 2024 | 8 | 6 | 14 | | 2025 | 6 | 3 | 9 |
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Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.
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Vanderlinden LA, Wong E, Johnson RK, Carry P, Dong F, Kechris K, Rewers M, Norris JM. DNA Methylation Smoking Scores and Risk of Islet Autoimmunity and Type 1 Diabetes. Diabetes Care. 2025 Sep 01; 48(9):1628-1636.
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Bergman BC, Zemski Berry K, Garfield A, Keller A, Zarini S, Bowen S, McKenna C, Kahn D, Pavelka J, Macias E, Uhlson C, Johnson C, Russ HA, Viesi CH, Seldin M, Liu C, Doliba NM, Schoen J, Rothchild K, Hazel K, Naji A. Human Peripancreatic Adipose Tissue Paracrine Signaling Impacts Insulin Secretion, Blood Flow, and Gene Transcription. J Clin Endocrinol Metab. 2025 Jun 17; 110(7):e2233-e2247.
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Hohenstein AC, Gallegos JB, Dang M, Groegler J, Broncucia H, Tensun FA, Waugh K, Dong F, James EA, Speake C, Steck AK, Rewers MJ, Gottlieb PA, Haskins K, Delong T, Baker RL. Novel T-Cell Reactivities to Hybrid Insulin Peptides in Islet Autoantibody-Positive At-Risk Individuals. Diabetes. 2025 Jun 01; 74(6):933-942.
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Campa-Carranza JN, Capuani S, Joubert AL, Hernandez N, Bo T, Sauceda-Villanueva OI, Conte M, Franco L, Farina M, Rome GE, Xu Y, Zheng J, Argueta LB, Niles JA, Nikolos F, Chua CYX, Chen SH, Nichols JE, Kenyon NS, Grattoni A. Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation. Adv Sci (Weinh). 2025 May; 12(20):e2411574.
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Akolade J, Crossley I, Farnsworth NL. Isolated Pancreatic Islet Treatment and Apoptosis Measurement. J Vis Exp. 2025 May 02; (219).
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Chen Y, Shen M, Gu Y, Xu X, Bian L, Yang F, Chen S, Ji L, Liu J, Zhu J, Zhang Z, Fu Q, Cai Y, Chen H, Xu K, Sun M, Zheng X, Shen J, Zhou H, Zhang M, Haskins K, Yu L, Yang T, Shi Y. Pivotal epitopes for islet antigen-specific CD8+ T cell detection improve classification of suspected type 1 diabetes with the HLA-A*0201 allele. Immunol Res. 2025 Mar 26; 73(1):65.
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Nicholas CA, Tensun FA, Evans SA, Toole KP, Prendergast JE, Broncucia H, Hesselberth JR, Gottlieb PA, Wells KL, Smith MJ. Activated polyreactive B cells are clonally expanded in autoantibody positive and patients with recent-onset type 1 diabetes. Cell Rep. 2025 Apr 22; 44(4):115425.
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Gresch A, Osthues J, Hüwel JD, Briggs JK, Berger T, Koch R, Deickert T, Beecks C, Benninger RKP, Düfer M. Resolving Spatiotemporal Electrical Signaling Within the Islet via CMOS Microelectrode Arrays. Diabetes. 2025 Mar 01; 74(3):343-354.
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Hilliard BK, Prendergast JE, Smith MJ. Dia-B-Ties: B Cells in the Islet-Immune-Cell Interface in T1D. Biomolecules. 2025 Feb 25; 15(3).
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Bandral M, Sussel L, Lorberbaum DS. Retinoid signaling in pancreas development, islet function, and disease. Curr Top Dev Biol. 2025; 161:297-318.
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