 Protein Engineering
"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
| Descriptor ID |
D015202
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| MeSH Number(s) |
E05.393.420.601
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| Concept/Terms |
Protein Engineering- Protein Engineering
- Engineering, Protein
- Genetic Engineering, Protein
- Engineering, Protein Genetic
- Protein Genetic Engineering
- Proteins, Genetic Engineering
- Genetic Engineering of Proteins
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Below are MeSH descriptors whose meaning is more general than "Protein Engineering".
Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".
This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 | | 1997 | 0 | 2 | 2 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 1 | 0 | 1 | | 2004 | 3 | 0 | 3 | | 2005 | 1 | 1 | 2 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 3 | 3 | | 2008 | 4 | 2 | 6 | | 2009 | 2 | 1 | 3 | | 2010 | 0 | 2 | 2 | | 2011 | 2 | 3 | 5 | | 2013 | 0 | 2 | 2 | | 2014 | 2 | 3 | 5 | | 2015 | 2 | 1 | 3 | | 2016 | 6 | 2 | 8 | | 2017 | 3 | 3 | 6 | | 2018 | 4 | 2 | 6 | | 2019 | 5 | 1 | 6 | | 2020 | 2 | 0 | 2 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 2 | 3 | | 2023 | 1 | 1 | 2 | | 2024 | 2 | 4 | 6 | | 2025 | 0 | 1 | 1 | | 2026 | 3 | 2 | 5 |
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Below are the most recent publications written about "Protein Engineering" by people in Profiles.
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Bell EL, Rosetto G, McGeehan JE, Sobkowicz MJ, Beckham GT. Challenges and opportunities in the enzymatic recycling of nylons. Nat Chem Biol. 2026 Jul; 22(7):1027-1043.
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Davis Z, Tian H, Wheeldon IR, Cutler SR, Whitehead TA. Protein Engineering of a Genetically Encodable Biosensor for Wastewater Detection of Profen NSAIDs. Biotechnol Bioeng. 2026 Jul; 123(7):1916-1928.
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Dai Y, Brouillard J, Jaycox JR, Yeon SM, Huck JD, Yandamuri SS, Zhong Z, O'Connor KC, Burnina I, Henkel C, LeMay AK, Lilov A, McGurk E, Morrill M, Parker L, Sackett T, Sandberg C, Sivasubramanian A, Geoghegan JC, Ring AM. Off-target reactivity in clinical monoclonal antibodies. Structure. 2026 May 07; 34(5):747-757.e5.
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Baumer ZT, Whitehead TA. Computational redesign of a thermostable T7 RNA polymerase. Protein Eng Des Sel. 2026 Jan 09; 39.
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Galindo G, Maejima D, DeRoo J, Burlingham SR, Fixen G, Morisaki T, Febvre HP, Hasbrook R, Zhao N, Ghosh S, Mayton EH, Snow CD, Geiss BJ, Ohkawa Y, Sato Y, Kimura H, Stasevich TJ. AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications. Sci Adv. 2026 Jan 02; 12(1):eadx8352.
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Ho AWS, Fukuzawa T, Koga H, Ohmine K, Kawauchi H, Muraoka M, Ikuta Y, Gupta G, Okuda M, Onami I, Ayabe M, Takeiri A, Konishi H, Sugawara Y, Usami S, Ito E, Shibahara N, Ozeki K, Wada Y, Hirako A, Takahashi N, Sampei Z, Haraya K, Murao N, Fujii T, Torizawa T, Shimada H, Igawa T. Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement function. EBioMedicine. 2025 Dec; 122:106009.
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Baumer ZT, Newton MS, Löfstrand L, Carpio Paucar GN, Farny NG, Whitehead TA. Engineered Stop and Go T7 RNA Polymerases. ACS Synth Biol. 2024 12 20; 13(12):4165-4174.
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Leonard AC, Friedman AJ, Chayer R, Petersen BM, Woojuh J, Xing Z, Cutler SR, Kaar JL, Shirts MR, Whitehead TA. Rationalizing Diverse Binding Mechanisms to the Same Protein Fold: Insights for Ligand Recognition and Biosensor Design. ACS Chem Biol. 2024 08 16; 19(8):1757-1772.
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Norton-Baker B, Denton MCR, Murphy NP, Fram B, Lim S, Erickson E, Gauthier NP, Beckham GT. Enabling high-throughput enzyme discovery and engineering with a low-cost, robot-assisted pipeline. Sci Rep. 2024 06 24; 14(1):14449.
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Petersen BM, Kirby MB, Chrispens KM, Irvin OM, Strawn IK, Haas CM, Walker AM, Baumer ZT, Ulmer SA, Ayala E, Rhodes ER, Guthmiller JJ, Steiner PJ, Whitehead TA. An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries. Nat Commun. 2024 May 10; 15(1):3974.
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