 Protein Engineering
"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
| Descriptor ID |
D015202
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| MeSH Number(s) |
E05.393.420.601
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| Concept/Terms |
Protein Engineering- Protein Engineering
- Engineering, Protein
- Genetic Engineering, Protein
- Engineering, Protein Genetic
- Protein Genetic Engineering
- Proteins, Genetic Engineering
- Genetic Engineering of Proteins
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Below are MeSH descriptors whose meaning is more general than "Protein Engineering".
Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".
This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 | | 1997 | 0 | 2 | 2 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 1 | 0 | 1 | | 2004 | 3 | 0 | 3 | | 2005 | 1 | 1 | 2 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 3 | 3 | | 2008 | 4 | 2 | 6 | | 2009 | 2 | 1 | 3 | | 2010 | 0 | 2 | 2 | | 2011 | 2 | 3 | 5 | | 2013 | 0 | 2 | 2 | | 2014 | 1 | 3 | 4 | | 2015 | 2 | 1 | 3 | | 2016 | 7 | 3 | 10 | | 2017 | 3 | 3 | 6 | | 2018 | 4 | 3 | 7 | | 2019 | 5 | 2 | 7 | | 2020 | 2 | 1 | 3 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 2 | 3 | | 2023 | 1 | 1 | 2 | | 2024 | 2 | 4 | 6 | | 2025 | 0 | 1 | 1 | | 2026 | 5 | 3 | 8 |
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Below are the most recent publications written about "Protein Engineering" by people in Profiles.
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Trabosh N, Smith J, Hsu MY, Panja S, Nagaraj R, Olsson N, McAllister FE, Cravens A. Reversal of protein chemical aging by enzymatic deglycation. Nat Commun. 2026 07 14; 17(1).
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Bell EL, Rosetto G, McGeehan JE, Sobkowicz MJ, Beckham GT. Challenges and opportunities in the enzymatic recycling of nylons. Nat Chem Biol. 2026 Jul; 22(7):1027-1043.
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Davis Z, Tian H, Wheeldon IR, Cutler SR, Whitehead TA. Protein Engineering of a Genetically Encodable Biosensor for Wastewater Detection of Profen NSAIDs. Biotechnol Bioeng. 2026 Jul; 123(7):1916-1928.
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Dai Y, Brouillard J, Jaycox JR, Yeon SM, Huck JD, Yandamuri SS, Zhong Z, O'Connor KC, Burnina I, Henkel C, LeMay AK, Lilov A, McGurk E, Morrill M, Parker L, Sackett T, Sandberg C, Sivasubramanian A, Geoghegan JC, Ring AM. Off-target reactivity in clinical monoclonal antibodies. Structure. 2026 May 07; 34(5):747-757.e5.
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Baumer ZT, Whitehead TA. Computational redesign of a thermostable T7 RNA polymerase. Protein Eng Des Sel. 2026 Jan 09; 39.
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Rhodes ER, Scarabelli G, Jou J, Byerly J, Sprenger KG, Oloo EO. Prioritizing stability-enhancing mutations using the ESM protein language model in conjunction with physics-based MM/GBSA predictions. Protein Eng Des Sel. 2026 Jan 09; 39.
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Ai HW, Arnold FH, Barrick D, Bayley H, Brownless AR, Campbell RE, Castells-Graells R, Chaiyen P, Chica RA, Chisholm LO, Christ D, Chu GC, Chungyoun M, Eijsink VGH, Elowitz MB, Fansher DJ, Fasan R, Foley G, Frei MS, Gagsteiger A, Gao R, Gillam EMJ, Gray JJ, Guerra LF, Höcker B, Jin Z, Kamerlin SCL, Koga N, Kontermann RE, Kuhlman B, Langlois OA, Li D, Lins RD, Liu CC, Liu L, López Barreiro D, Lu P, Mehta S, Miyazaki I, Müller MM, Muyldermans S, Nemoto N, Nivala J, Nuñez JK, Ornelas IJ, Pelletier JN, Plückthun A, Porth OT, Prakinee K, Qing Y, Reisenbauer JC, Schmidt S, Seifert O, Shapiro MG, Sharma R, Singh N, Smith BJ, Spangler JB, Tatsumi-Koga R, Terai T, Terholsen H, Tolhurst M, Tripp KW, Trossmann VT, Tucker CL, Turak O, Van Deventer JA, Várnai A, Viana IFT, Weeks AM, Wittrup KD, Wong KL, Xi C, Yeates TO, Yeh AH, Zhang J, Zhang TS, Zhao H, Zheng F, Zhu J, Zinn S. Protein engineering: status report. Protein Eng Des Sel. 2026 Jan 09; 39.
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Galindo G, Maejima D, DeRoo J, Burlingham SR, Fixen G, Morisaki T, Febvre HP, Hasbrook R, Zhao N, Ghosh S, Mayton EH, Snow CD, Geiss BJ, Ohkawa Y, Sato Y, Kimura H, Stasevich TJ. AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications. Sci Adv. 2026 Jan 02; 12(1):eadx8352.
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Ho AWS, Fukuzawa T, Koga H, Ohmine K, Kawauchi H, Muraoka M, Ikuta Y, Gupta G, Okuda M, Onami I, Ayabe M, Takeiri A, Konishi H, Sugawara Y, Usami S, Ito E, Shibahara N, Ozeki K, Wada Y, Hirako A, Takahashi N, Sampei Z, Haraya K, Murao N, Fujii T, Torizawa T, Shimada H, Igawa T. Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement function. EBioMedicine. 2025 Dec; 122:106009.
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Wang S, Zhang P, Sun Y, Fang Y, Wang P, Shao M, Zhang N, Shi S, Chen X, Gao H, Cheng J, Gao B, Liu T, Qian Q, Song C. Engineering of BZ transposase and transposon donor vector for enhanced efficiency and safety in gene delivery applications. Nucleic Acids Res. 2025 Sep 23; 53(18).
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