 Protein Engineering
"Protein Engineering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
| Descriptor ID |
D015202
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| MeSH Number(s) |
E05.393.420.601
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| Concept/Terms |
Protein Engineering- Protein Engineering
- Engineering, Protein
- Genetic Engineering, Protein
- Engineering, Protein Genetic
- Protein Genetic Engineering
- Proteins, Genetic Engineering
- Genetic Engineering of Proteins
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Below are MeSH descriptors whose meaning is more general than "Protein Engineering".
Below are MeSH descriptors whose meaning is more specific than "Protein Engineering".
This graph shows the total number of publications written about "Protein Engineering" by people in this website by year, and whether "Protein Engineering" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 3 | 3 | | 1996 | 0 | 2 | 2 | | 1997 | 0 | 2 | 2 | | 1998 | 1 | 1 | 2 | | 1999 | 0 | 3 | 3 | | 2000 | 1 | 1 | 2 | | 2001 | 0 | 2 | 2 | | 2002 | 1 | 1 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 3 | 0 | 3 | | 2005 | 2 | 1 | 3 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 3 | 3 | | 2008 | 4 | 2 | 6 | | 2009 | 2 | 2 | 4 | | 2010 | 0 | 3 | 3 | | 2011 | 2 | 3 | 5 | | 2013 | 2 | 1 | 3 | | 2014 | 2 | 2 | 4 | | 2015 | 2 | 2 | 4 | | 2016 | 4 | 2 | 6 | | 2017 | 2 | 2 | 4 | | 2018 | 4 | 2 | 6 | | 2019 | 5 | 1 | 6 | | 2020 | 1 | 1 | 2 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 2 | 3 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Engineering" by people in Profiles.
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Daffern N, Francino-Urdaniz IM, Baumer ZT, Whitehead TA. Standardizing cassette-based deep mutagenesis by Golden Gate assembly. Biotechnol Bioeng. 2024 01; 121(1):281-290.
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Leonard AC, Whitehead TA. Design and engineering of genetically encoded protein biosensors for small molecules. Curr Opin Biotechnol. 2022 Dec; 78:102787.
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Raeeszadeh-Sarmazdeh M, Coban M, Mahajan S, Hockla A, Sankaran B, Downey GP, Radisky DC, Radisky ES. Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10. J Biol Chem. 2022 03; 298(3):101654.
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Kirby MB, Whitehead TA. Facile Assembly of Combinatorial Mutagenesis Libraries Using Nicking Mutagenesis. Methods Mol Biol. 2022; 2461:85-109.
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Kirby MB, Medina-Cucurella AV, Baumer ZT, Whitehead TA. Optimization of multi-site nicking mutagenesis for generation of large, user-defined combinatorial libraries. Protein Eng Des Sel. 2021 02 15; 34.
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Plaks JG, Brewer JA, Jacobsen NK, McKenna M, Uzarski JR, Lawton TJ, Filocamo SF, Kaar JL. Rosetta-Enabled Structural Prediction of Permissive Loop Insertion Sites in Proteins. Biochemistry. 2020 10 20; 59(41):3993-4002.
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Knott BC, Erickson E, Allen MD, Gado JE, Graham R, Kearns FL, Pardo I, Topuzlu E, Anderson JJ, Austin HP, Dominick G, Johnson CW, Rorrer NA, Szostkiewicz CJ, Copi? V, Payne CM, Woodcock HL, Donohoe BS, Beckham GT, McGeehan JE. Characterization and engineering of a two-enzyme system for plastics depolymerization. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25476-25485.
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Oh EJ, Liu R, Liang L, Freed EF, Eckert CA, Gill RT. Multiplex Evolution of Antibody Fragments Utilizing a Yeast Surface Display Platform. ACS Synth Biol. 2020 08 21; 9(8):2197-2202.
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Medina-Cucurella AV, Steiner PJ, Faber MS, Beltr?n J, Borelli AN, Kirby MB, Cutler SR, Whitehead TA. User-defined single pot mutagenesis using unamplified oligo pools. Protein Eng Des Sel. 2019 09 10; 32(1):41-45.
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Machovina MM, Mallinson SJB, Knott BC, Meyers AW, Garcia-Borr?s M, Bu L, Gado JE, Oliver A, Schmidt GP, Hinchen DJ, Crowley MF, Johnson CW, Neidle EL, Payne CM, Houk KN, Beckham GT, McGeehan JE, DuBois JL. Enabling microbial syringol conversion through structure-guided protein engineering. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):13970-13976.
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