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Chandra L Tucker

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PHARM General Operations
Phone303/724-6337

    Collapse Research 
    Collapse research activities and funding
    R21MH134019     (KENNEDY, MATTHEW J)Aug 15, 2023 - Aug 14, 2025
    NIH
    Tools for manipulating protein condensates at the synapse
    Role: Co-Principal Investigator
    R21EY031269     (NORRIS, AARON J)Jun 1, 2020 - May 31, 2022
    NIH
    Light-Induced Targeted Recombination Strategies For Genetic Access to Recently Active Neurons
    Role: Co-Principal Investigator
    R35GM136367     (TUCKER, CHANDRA L)Apr 1, 2020 - Mar 31, 2025
    NIH
    Uncovering new approaches to manipulate and probe biochemical processes with spatial and temporal precision.
    Role: Principal Investigator
    UF1NS107710     (KENNEDY, MATTHEW J)Sep 30, 2018 - Sep 29, 2021
    NIH
    Validating and extending optical tools for extended neural silencing
    Role: Co-Principal Investigator
    R21GM126253     (TUCKER, CHANDRA L)Sep 16, 2017 - Jul 31, 2020
    NIH
    Optogenetic control of protein assembly
    Role: Principal Investigator
    R21EY026363     (KENNEDY, MATTHEW J)Sep 30, 2015 - Sep 29, 2018
    NIH
    Optical tools for extended neural silencing
    Role: Co-Principal Investigator
    R01GM100225     (TUCKER, CHANDRA L)Apr 1, 2012 - Jul 31, 2021
    NIH
    Control of Protein Activity Via Light Stimulated Dimerizers
    Role: Principal Investigator
    R01DK081584     (TUCKER, CHANDRA L)Sep 1, 2008 - Aug 31, 2013
    NIH
    Analysis of PH1-associated alanine:glyoxylate aminotranferase (AGT) using yeast
    Role: Principal Investigator
    R21DK075291     (TUCKER, CHANDRA L)Mar 1, 2008 - Feb 28, 2011
    NIH
    Identification of pharmacological chaperones for misfolded proteins
    Role: Principal Investigator
    F32GM020532     (TUCKER, CHANDRA L)Sep 1, 2000
    NIH
    ENGINEERING A YEAST SENSOR OF LIGAND-BINDING
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Hernandez-Candia CN, Brady BR, Harrison E, Tucker CL. A platform to induce and mature biomolecular condensates using chemicals and light. Nat Chem Biol. 2024 Apr; 20(4):452-462. PMID: 38191942.
      View in: PubMed
    2. Taslimi A, Fields KM, Dahl KD, Liu Q, Tucker CL. Spatiotemporal control of necroptotic cell death and plasma membrane recruitment using engineered MLKL domains. Cell Death Discov. 2022 Nov 29; 8(1):469. PMID: 36446770.
      View in: PubMed
    3. Cleveland JD, Taslimi A, Liu Q, Van Keuren AM, Churchill MEA, Tucker CL. Reprogramming the Cleavage Specificity of Botulinum Neurotoxin Serotype B1. ACS Synth Biol. 2022 10 21; 11(10):3318-3329. PMID: 36153971.
      View in: PubMed
    4. Hern?ndez-Candia CN, Pearce S, Tucker CL. A modular tool to query and inducibly disrupt biomolecular condensates. Nat Commun. 2021 03 22; 12(1):1809. PMID: 33753744.
      View in: PubMed
    5. Pearce S, Tucker CL. Dual Systems for Enhancing Control of Protein Activity through Induced Dimerization Approaches. Adv Biol (Weinh). 2021 05; 5(5):e2000234. PMID: 34028215.
      View in: PubMed
    6. Cleveland JD, Tucker CL. Photo-SNAP-tag, a Light-Regulated Chemical Labeling System. ACS Chem Biol. 2020 08 21; 15(8):2212-2220. PMID: 32623878.
      View in: PubMed
    7. Hern?ndez-Candia CN, Tucker CL. Optogenetic Control of Gene Expression Using Cryptochrome 2 and a Light-Activated Degron. Methods Mol Biol. 2020; 2173:151-158. PMID: 32651916.
      View in: PubMed
    8. Meador K, Wysoczynski CL, Norris AJ, Aoto J, Bruchas MR, Tucker CL. Achieving tight control of a photoactivatable Cre recombinase gene switch: new design strategies and functional characterization in mammalian cells and rodent. Nucleic Acids Res. 2019 09 26; 47(17):e97. PMID: 31287871.
      View in: PubMed
    9. Hern?ndez-Candia CN, Wysoczynski CL, Tucker CL. Advances in optogenetic regulation of gene expression in mammalian cells using cryptochrome 2 (CRY2). Methods. 2019 07 15; 164-165:81-90. PMID: 30905749.
      View in: PubMed
    10. Spiltoir JI, Tucker CL. Photodimerization systems for regulating protein-protein interactions with light. Curr Opin Struct Biol. 2019 08; 57:1-8. PMID: 30818200.
      View in: PubMed
    11. Liu Q, Sinnen BL, Boxer EE, Schneider MW, Grybko MJ, Buchta WC, Gibson ES, Wysoczynski CL, Ford CP, Gottschalk A, Aoto J, Tucker CL, Kennedy MJ. A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron. 2019 03 06; 101(5):863-875.e6. PMID: 30704911.
      View in: PubMed
    12. Locke C, Machida K, Tucker CL, Wu Y, Yu J. Correction: Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase. Biol Open. 2018 04 23; 7(4). PMID: 29685998.
      View in: PubMed
    13. Cook SG, Bourke AM, O'Leary H, Zaegel V, Lasda E, Mize-Berge J, Quillinan N, Tucker CL, Coultrap SJ, Herson PS, Bayer KU. Analysis of the CaMKIIa and ? splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep. 2018 04 03; 8(1):5448. PMID: 29615706.
      View in: PubMed
    14. Locke C, Machida K, Wu Y, Yu J. Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase. Biol Open. 2017 12 15; 6(12):1820-1830. PMID: 29158322.
      View in: PubMed
    15. Pathak GP, Spiltoir JI, H?glund C, Polstein LR, Heine-Koskinen S, Gersbach CA, Rossi J, Tucker CL. Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2. Nucleic Acids Res. 2017 Nov 16; 45(20):e167. PMID: 28431041.
      View in: PubMed
    16. Liu Q, Tucker CL. Engineering genetically-encoded tools for optogenetic control of protein activity. Curr Opin Chem Biol. 2017 Oct; 40:17-23. PMID: 28527343.
      View in: PubMed
    17. Taslimi A, Zoltowski B, Miranda JG, Pathak GP, Hughes RM, Tucker CL. Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase. Nat Chem Biol. 2016 06; 12(6):425-30. PMID: 27065233.
      View in: PubMed
    18. Spiltoir JI, Strickland D, Glotzer M, Tucker CL. Optical Control of Peroxisomal Trafficking. ACS Synth Biol. 2016 07 15; 5(7):554-60. PMID: 26513473.
      View in: PubMed
    19. Schindler SE, McCall JG, Yan P, Hyrc KL, Li M, Tucker CL, Lee JM, Bruchas MR, Diamond MI. Photo-activatable Cre recombinase regulates gene expression in vivo. Sci Rep. 2015 Sep 09; 5:13627. PMID: 26350769.
      View in: PubMed
    20. Pathak GP, Strickland D, Vrana JD, Tucker CL. Benchmarking of optical dimerizer systems. ACS Synth Biol. 2014 Nov 21; 3(11):832-8. PMID: 25350266.
      View in: PubMed
    21. Taslimi A, Vrana JD, Chen D, Borinskaya S, Mayer BJ, Kennedy MJ, Tucker CL. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun. 2014 Sep 18; 5:4925. PMID: 25233328.
      View in: PubMed
    22. Tucker CL, Vrana JD, Kennedy MJ. Tools for controlling protein interactions using light. Curr Protoc Cell Biol. 2014 Sep 02; 64:17.16.1-20. PMID: 25181301.
      View in: PubMed
    23. Hanson MG, Fregoso VL, Vrana JD, Tucker CL, Niswander LA. Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders. Dev Biol. 2014 Nov 01; 395(1):84-95. PMID: 25176044.
      View in: PubMed
    24. Lage MD, Pittman AM, Roncador A, Cellini B, Tucker CL. Allele-specific characterization of alanine: glyoxylate aminotransferase variants associated with primary hyperoxaluria. PLoS One. 2014; 9(4):e94338. PMID: 24718375.
      View in: PubMed
    25. Pathak GP, Vrana JD, Tucker CL. Optogenetic control of cell function using engineered photoreceptors. Biol Cell. 2013 Feb; 105(2):59-72. PMID: 23157573.
      View in: PubMed
    26. Pittman AM, Lage MD, Poltoratsky V, Vrana JD, Paiardini A, Roncador A, Cellini B, Hughes RM, Tucker CL. Rapid profiling of disease alleles using a tunable reporter of protein misfolding. Genetics. 2012 Nov; 192(3):831-42. PMID: 22923379.
      View in: PubMed
    27. Hughes RM, Bolger S, Tapadia H, Tucker CL. Light-mediated control of DNA transcription in yeast. Methods. 2012 Dec; 58(4):385-91. PMID: 22922268.
      View in: PubMed
    28. Hughes RM, Vrana JD, Song J, Tucker CL. Light-dependent, dark-promoted interaction between Arabidopsis cryptochrome 1 and phytochrome B proteins. J Biol Chem. 2012 Jun 22; 287(26):22165-72. PMID: 22577138.
      View in: PubMed
    29. Pajerowska-Mukhtar KM, Wang W, Tada Y, Oka N, Tucker CL, Fonseca JP, Dong X. The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition. Curr Biol. 2012 Jan 24; 22(2):103-12. PMID: 22244999.
      View in: PubMed
    30. Tucker CL. Manipulating cellular processes using optical control of protein-protein interactions. Prog Brain Res. 2012; 196:95-117. PMID: 22341323.
      View in: PubMed
    31. Kennedy MJ, Hughes RM, Peteya LA, Schwartz JW, Ehlers MD, Tucker CL. Rapid blue-light-mediated induction of protein interactions in living cells. Nat Methods. 2010 Dec; 7(12):973-5. PMID: 21037589.
      View in: PubMed
    32. West GM, Tucker CL, Xu T, Park SK, Han X, Yates JR, Fitzgerald MC. Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements. Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9078-82. PMID: 20439767.
      View in: PubMed
    33. Hopper ED, Pittman AM, Tucker CL, Campa MJ, Patz EF, Fitzgerald MC. Hydrogen/deuterium exchange- and protease digestion-based screening assay for protein-ligand binding detection. Anal Chem. 2009 Aug 15; 81(16):6860-7. PMID: 20337380.
      View in: PubMed
    34. Tucker CL, Peteya LA, Pittman AM, Zhong J. A genetic test for yeast two-hybrid bait competency using RanBPM. Genetics. 2009 Aug; 182(4):1377-9. PMID: 19487565.
      View in: PubMed
    35. Hopper ED, Pittman AM, Fitzgerald MC, Tucker CL. In vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase. J Biol Chem. 2008 Nov 07; 283(45):30493-502. PMID: 18782763.
      View in: PubMed
    36. Tucker CL, Ramamurthy V, Pina AL, Loyer M, Dharmaraj S, Li Y, Maumenee IH, Hurley JB, Koenekoop RK. Functional analyses of mutant recessive GUCY2D alleles identified in Leber congenital amaurosis patients: protein domain comparisons and dominant negative effects. Mol Vis. 2004 Apr 20; 10:297-303. PMID: 15123990.
      View in: PubMed
    37. Tucker CL, Fields S. Quantitative genome-wide analysis of yeast deletion strain sensitivities to oxidative and chemical stress. Comp Funct Genomics. 2004; 5(3):216-24. PMID: 18629161.
      View in: PubMed
    38. Tucker CL, Fields S. Lethal combinations. Nat Genet. 2003 Nov; 35(3):204-5. PMID: 14593402.
      View in: PubMed
    39. Brockerhoff SE, Rieke F, Matthews HR, Taylor MR, Kennedy B, Ankoudinova I, Niemi GA, Tucker CL, Xiao M, Cilluffo MC, Fain GL, Hurley JB. Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. J Neurosci. 2003 Jan 15; 23(2):470-80. PMID: 12533607.
      View in: PubMed
    40. Tucker CL. High-throughput cell-based assays in yeast. Drug Discov Today. 2002 Sep 15; 7(18 Suppl):S125-30. PMID: 12546878.
      View in: PubMed
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