 Leukoencephalopathy, Progressive Multifocal
"Leukoencephalopathy, Progressive Multifocal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
| Descriptor ID |
D007968
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| MeSH Number(s) |
C02.182.525.500 C02.256.721.500 C02.290.575 C02.839.550 C10.228.140.430.520.750.500 C10.228.140.695.750 C10.228.228.245.340.500 C10.228.228.399.750.500 C10.314.450
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| Concept/Terms |
Leukoencephalopathy, Progressive Multifocal- Leukoencephalopathy, Progressive Multifocal
- Leukoencephalopathies, Progressive Multifocal
- Multifocal Leukoencephalopathies, Progressive
- Multifocal Leukoencephalopathy, Progressive
- Progressive Multifocal Leukoencephalopathies
- Progressive Multifocal Leukoencephalopathy
- JC Polyomavirus Encephalopathy
- Encephalopathies, JC Polyomavirus
- Encephalopathy, JC Polyomavirus
- Encephalitis, JC Polyomavirus
- JC Polyomavirus Encephalitis
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Below are MeSH descriptors whose meaning is more general than "Leukoencephalopathy, Progressive Multifocal".
- Diseases [C]
- Virus Diseases [C02]
- Central Nervous System Viral Diseases [C02.182]
- Encephalitis, Viral [C02.182.525]
- Leukoencephalopathy, Progressive Multifocal [C02.182.525.500]
- DNA Virus Infections [C02.256]
- Polyomavirus Infections [C02.256.721]
- Leukoencephalopathy, Progressive Multifocal [C02.256.721.500]
- Encephalitis, Viral [C02.290]
- Leukoencephalopathy, Progressive Multifocal [C02.290.575]
- Slow Virus Diseases [C02.839]
- Leukoencephalopathy, Progressive Multifocal [C02.839.550]
- Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
- Brain Diseases [C10.228.140]
- Encephalitis [C10.228.140.430]
- Infectious Encephalitis [C10.228.140.430.520]
- Encephalitis, Viral [C10.228.140.430.520.750]
- Leukoencephalopathy, Progressive Multifocal [C10.228.140.430.520.750.500]
- Leukoencephalopathies [C10.228.140.695]
- Leukoencephalopathy, Progressive Multifocal [C10.228.140.695.750]
- Central Nervous System Infections [C10.228.228]
- Central Nervous System Viral Diseases [C10.228.228.245]
- Encephalitis, Viral [C10.228.228.245.340]
- Leukoencephalopathy, Progressive Multifocal [C10.228.228.245.340.500]
- Infectious Encephalitis [C10.228.228.399]
- Encephalitis, Viral [C10.228.228.399.750]
- Leukoencephalopathy, Progressive Multifocal [C10.228.228.399.750.500]
- Demyelinating Diseases [C10.314]
- Leukoencephalopathy, Progressive Multifocal [C10.314.450]
Below are MeSH descriptors whose meaning is more specific than "Leukoencephalopathy, Progressive Multifocal".
This graph shows the total number of publications written about "Leukoencephalopathy, Progressive Multifocal" by people in this website by year, and whether "Leukoencephalopathy, Progressive Multifocal" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 2 | 0 | 2 | | 1999 | 3 | 0 | 3 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 2 | 1 | 3 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 4 | 0 | 4 | | 2010 | 3 | 0 | 3 | | 2011 | 4 | 0 | 4 | | 2012 | 1 | 0 | 1 | | 2013 | 2 | 0 | 2 | | 2015 | 2 | 0 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Leukoencephalopathy, Progressive Multifocal" by people in Profiles.
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Rempe T, Wang Q, Wu Q, Ballur Narayana Reddy V, Newcomer Z, Miravalle A, Mao-Draayer Y. Progressive multifocal leukoencephalopathy and granule cell neuronopathy with novel mutation flanking VP1 C-terminus in natalizumab-extended interval dosing. Neurol Neuroimmunol Neuroinflamm. 2020 05 04; 7(3).
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Clifford DB, Tyler KL. Dosing interval of natalizumab in MS: Do good things come to those who wait? Neurology. 2019 10 08; 93(15):655-656.
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Tyler KL, Vollmer TL. To PLEX or not to PLEX in natalizumab-associated PML. Neurology. 2017 03 21; 88(12):1108-1109.
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Zerbe CS, Marciano BE, Katial RK, Santos CB, Adamo N, Hsu AP, Hanks ME, Darnell DN, Quezado MM, Frein C, Barnhart LA, Anderson VL, Uzel G, Freeman AF, Lisco A, Nath A, Major EO, Sampaio EP, Holland SM. Progressive Multifocal Leukoencephalopathy in Primary Immune Deficiencies: Stat1 Gain of Function and Review of the Literature. Clin Infect Dis. 2016 Apr 15; 62(8):986-94.
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Patera AC, Butler SL, Cinque P, Clifford DB, Elston R, Garcea RL, Major EO, Pavlovic D, Peterson IS, Ryan AM, Tyler KL, Weber T. 2nd International Conference on Progressive Multifocal Leukoencephalopathy (PML) 2015: JCV virology, progressive multifocal leukoencephalopathy pathogenesis, diagnosis and risk stratification, and new approaches to prevention and treatment. J Neurovirol. 2015 Dec; 21(6):702-5.
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Scott FI, Osterman MT. Natalizumab for Crohn's Disease: Down but Not Out. Clin Gastroenterol Hepatol. 2015 Nov; 13(11):1926-8.
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Sospedra M, Schippling S, Yousef S, Jelcic I, Bofill-Mas S, Planas R, Stellmann JP, Demina V, Cinque P, Garcea R, Croughs T, Girones R, Martin R. Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1. Clin Infect Dis. 2014 Dec 01; 59(11):1588-92.
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Thaker AA, Schmitt SE, Pollard JR, Dubroff JG. Natalizumab-induced progressive multifocal leukoencephalopathy. Clin Nucl Med. 2014 Jul; 39(7):e365-6.
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Scott FI, Osterman MT, McConnell RA, Lorusso M, Aberra F, Kerner C, Lichtenstein GR, Lewis JD. Impact of JC virus antibody testing in patients with Crohn's disease with loss of response to infliximab: a Markov model. Inflamm Bowel Dis. 2013 Nov; 19(12):2625-33.
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Tyler KL. PML therapy: "It's D?j? vu all over again". J Neurovirol. 2013 Aug; 19(4):311-3.
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