 Subacute Sclerosing Panencephalitis
"Subacute Sclerosing Panencephalitis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
| Descriptor ID |
D013344
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| MeSH Number(s) |
C02.182.525.600 C02.290.700 C02.782.580.600.500.500.800 C02.839.862 C10.228.140.430.520.750.600 C10.228.228.245.340.600 C10.228.228.399.750.600
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| Concept/Terms |
Subacute Sclerosing Panencephalitis- Subacute Sclerosing Panencephalitis
- Sclerosing Panencephalitis, Subacute
- Panencephalitides, Subacute Sclerosing
- Sclerosing Panencephalitides, Subacute
- Subacute Sclerosing Panencephalitides
- Panencephalitis, Subacute Sclerosing
- Leukoencephalitis, Van Bogaert's
- Leukoencephalitis, Van Bogaert
- Leukoencephalitis, Van Bogaerts
- Inclusion Body Encephalitis, Measles
- Sclerosing Leukoencephalitis, Subacute
- Leukoencephalitides, Subacute Sclerosing
- Sclerosing Leukoencephalitides, Subacute
- Subacute Sclerosing Leukoencephalitides
- Subacute Sclerosing Leukoencephalitis
- Leukoencephalitis, Subacute Sclerosing
- Measles Inclusion Body Encephalitis
- Encephaltis, Inclusion Body, Measles
- SSPE
- Van Bogaert's Leukoencephalitis
- Van Bogaert Leukoencephalitis
- Van Bogaerts Leukoencephalitis
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Below are MeSH descriptors whose meaning is more general than "Subacute Sclerosing Panencephalitis".
Below are MeSH descriptors whose meaning is more specific than "Subacute Sclerosing Panencephalitis".
This graph shows the total number of publications written about "Subacute Sclerosing Panencephalitis" by people in this website by year, and whether "Subacute Sclerosing Panencephalitis" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2005 | 1 | 0 | 1 | | 2006 | 2 | 0 | 2 |
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Below are the most recent publications written about "Subacute Sclerosing Panencephalitis" by people in Profiles.
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Owens GP, Shearer AJ, Yu X, Ritchie AM, Keays KM, Bennett JL, Gilden DH, Burgoon MP. Screening random peptide libraries with subacute sclerosing panencephalitis brain-derived recombinant antibodies identifies multiple epitopes in the C-terminal region of the measles virus nucleocapsid protein. J Virol. 2006 Dec; 80(24):12121-30.
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Burgoon MP, Caldas YA, Keays KM, Yu X, Gilden DH, Owens GP. Recombinant antibodies generated from both clonal and less abundant plasma cell immunoglobulin G sequences in subacute sclerosing panencephalitis brain are directed against measles virus. J Neurovirol. 2006 Oct; 12(5):398-402.
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Burgoon MP, Keays KM, Owens GP, Ritchie AM, Rai PR, Cool CD, Gilden DH. Laser-capture microdissection of plasma cells from subacute sclerosing panencephalitis brain reveals intrathecal disease-relevant antibodies. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7245-50.
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Burgoon MP, Hammack BN, Owens GP, Maybach AL, Eikelenboom MJ, Gilden DH. Oligoclonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (VZV) vasculopathy are directed against VZV. Ann Neurol. 2003 Oct; 54(4):459-63.
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Dlugos DJ, Brooks-Kayal AR. A 4-year-old with pica, progressive incoordination, and decreased responsiveness. Semin Pediatr Neurol. 1999 Sep; 6(3):164-7.
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Ogle JW, Toltzis P, Parker WD, Alvarez N, McIntosh K, Levin MJ, Lauer BA. Oral ribavirin therapy for subacute sclerosing panencephalitis. J Infect Dis. 1989 Apr; 159(4):748-50.
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Weiner HL, Schocket AL, Lehrich JR. Lymphocytotix antibodies in subacute sclerosing panencephalitis and amyotrophic lateral sclerosis. Lancet. 1977 May 07; 1(8019):1013-4.
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