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Bennett Chin

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-RAD General Operations

    Collapse Biography 
    Collapse education and training
    University of Texas Medical Br, Galveston, TexasMD05/1987Medicine
    Methodist Medical Center, Dallas, TexasABIM06/1990Internal Medicine
    Harvard Joint Program Nuclear Med, Boston, MA06/1991Nuclear Medicine
    Johns Hopkins University, Baltimore, MDABNM06/1992Nuclear Medicine

    Collapse Overview 
    Collapse overview
    As a clinician-scientist, my goal is to advance scientific discoveries into clinical practice. In molecular imaging and therapies (theranostics), a primary goal is to bring novel, highly effective targeted radionuclide imaging and therapies to diagnose and treat cancers based on individual tumor and patient specific characteristics.

    Collapse Research 
    Collapse research activities and funding
         (CHIN, BENNETT B)Dec 1, 2018
    Phase III Industry Sponsored Theranostic Clinical Trial
    VISION: An international, prospective, open label, multicenter, randomized Phase 3 study of 177Lu-PSMA-617 in the treatment of patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC)
    Role: Site Principal Investigator for University of Colorado
         (CHIN, BENNETT B)Dec 1, 2014 - Nov 30, 2017
    Phase IIb Industry Sponsored Theranostic Clinical Trial
    Phase IIb Study Evaluating Ultratrace Iobenguane I 131 (MIBG) in Patients With Malignant Pheochromocytoma/Paraganglioma
    Role: Site Principal Investigator
    S10RR031792     (CHIN, BENNETT B)Apr 1, 2011 - Mar 31, 2012
    NIH
    Small Animal PET/SPECT/CT Molecular Imaging
    Role: Principal Investigator
    5R44CA130394     (KRONAUGE, JAMES)Aug 12, 2009 - Jul 31, 2011
    NIH
    Nanodosing: A path to higher sensitivity and lower toxicity pharmaceuticals
    Role Description: Phase II Clinical trial of high specific activity meta-iodobenzylguanidine
    Role: Principal Investigator for Investigator Initiated IND, and Principal Investigator for this clinical
    BC073244     (CHIN, BENNETT B)Mar 3, 2008 - Jul 28, 2014
    Department of Defense, Breast Cancer Grant
    Radionuclide Imaging of Breast Cancer Stem Cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Yang X, Chin BB, Silosky M, Wehrend J, Litwiller DV, Ghosh D, Xing F. Learning Without Real Data Annotations to Detect Hepatic Lesions in PET Images. IEEE Trans Biomed Eng. 2024 Feb; 71(2):679-688. PMID: 37708016.
      View in: PubMed
    2. Xing F, Silosky M, Ghosh D, Chin BB. Location-Aware Encoding for Lesion Detection in 68Ga-DOTATATE Positron Emission Tomography Images. IEEE Trans Biomed Eng. 2024 Jan; 71(1):247-257. PMID: 37471190.
      View in: PubMed
    3. Silosky M, Xing F, Wehrend J, Litwiller DV, Metzler SD, Chin BB. Modeling contrast-to-noise ratio from list mode reconstructions of 68Ga DOTATATE PET/CT: predicting detectability of hepatic metastases in shorter acquisition PET reconstructions. Am J Nucl Med Mol Imaging. 2023; 13(1):33-42. PMID: 36923602.
      View in: PubMed
    4. Jimenez C, Chin BB, Noto RB, Dillon JS, Solnes L, Stambler N, DiPippo VA, Pryma DA. Biomarker response to high-specific-activity I-131 meta-iodobenzylguanidine in pheochromocytoma/paraganglioma. Endocr Relat Cancer. 2023 02 01; 30(2). PMID: 36472300.
      View in: PubMed
    5. Grey N, Silosky M, Lieu CH, Chin BB. Current status and future of targeted peptide receptor radionuclide positron emission tomography imaging and therapy of gastroenteropancreatic-neuroendocrine tumors. World J Gastroenterol. 2022 May 07; 28(17):1768-1780. PMID: 35633909.
      View in: PubMed
    6. Lin EP, Chin BB, Fishbein L, Moritani T, Montoya SP, Ellika S, Newlands S. Head and Neck Paragangliomas: An Update on the Molecular Classification, State-of-the-Art Imaging, and Management Recommendations. Radiol Imaging Cancer. 2022 05; 4(3):e210088. PMID: 35549357.
      View in: PubMed
    7. Silosky MS, Patten LW, Chin BB. Small target repeatability of 68Ga and 18F: effects of target concentration and imaging time on SUV measurements in clinically relevant phantoms. Am J Nucl Med Mol Imaging. 2021; 11(4):280-289. PMID: 34513281.
      View in: PubMed
    8. Silosky MS, Karki R, Morgan R, Anderson J, Chin BB. Physical characteristics of 68Ga DOTATATE PET/CT affecting small lesion detectability. Am J Nucl Med Mol Imaging. 2021; 11(1):27-39. PMID: 33688453.
      View in: PubMed
    9. Schmidt MQ, Trenbeath Z, Chin BB. Neuroendocrine prostate cancer or prostatitis? An unusual false positive on gallium-68 DOTA-Tyr3-octreotate positron emission tomography/computed tomography in a patient with known metastatic neuroendocrine tumor. World J Nucl Med. 2019 Jul-Sep; 18(3):304-306. PMID: 31516377.
      View in: PubMed
    10. Liu Y, Carpenter AB, Pirozzi CJ, Yuan H, Waitkus MS, Zhou Z, Hansen L, Seywald M, Odion R, Greer PK, Hawk T, Chin BB, Vaidyanathan G, Zalutsky MR, Yan H, Vo-Dinh T. Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe. Nanotechnology. 2019 Jul 05; 30(27):275101. PMID: 30856613.
      View in: PubMed
    11. Morgan R, Chin BB, Lanning R. Feasibility of rapid integrated radiation therapy planning with follow-up FDG PET/CT to improve overall treatment assessment in head and neck cancer. Am J Nucl Med Mol Imaging. 2019; 9(1):24-29. PMID: 30911435.
      View in: PubMed
    12. Pryma DA, Chin BB, Noto RB, Dillon JS, Perkins S, Solnes L, Kostakoglu L, Serafini AN, Pampaloni MH, Jensen J, Armor T, Lin T, White T, Stambler N, Apfel S, DiPippo VA, Mahmood S, Wong V, Jimenez C. Efficacy and Safety of High-Specific-Activity 131I-MIBG Therapy in Patients with Advanced Pheochromocytoma or Paraganglioma. J Nucl Med. 2019 05; 60(5):623-630. PMID: 30291194.
      View in: PubMed
    13. Cho MW, Chin BB. 18F-FDG PET/CT findings in hepatosplenic Gamma-Delta T-cell lymphoma: case reports and review of the literature. Am J Nucl Med Mol Imaging. 2018; 8(2):137-142. PMID: 29755847.
      View in: PubMed
    14. Chin BB, McDougald D, Weitzel DH, Hawk T, Reiman RE, Zalutsky MR, Vaidyanathan G. Synthesis and Preliminary Evaluation of 5-[18F]fluoroleucine. Curr Radiopharm. 2017; 10(1):41-50. PMID: 28034351.
      View in: PubMed
    15. Oldan JD, Chin BB. FDG PET/CT Imaging of Prostate Carcinosarcoma. Clin Nucl Med. 2016 Aug; 41(8):629-31. PMID: 27187727.
      View in: PubMed
    16. Oldan JD, Hawkins AS, Chin BB. (18)F Sodium Fluoride PET/CT in Patients with Prostate Cancer: Quantification of Normal Tissues, Benign Degenerative Lesions, and Malignant Lesions. World J Nucl Med. 2016 May-Aug; 15(2):102-8. PMID: 27134560.
      View in: PubMed
    17. Yerubandi V, Chin BB, Sosa JA, Hoang JK. Incidental Thyroid Nodules at Non-FDG PET Nuclear Medicine Imaging: Evaluation of Prevalence and Malignancy Rate. AJR Am J Roentgenol. 2016 Feb; 206(2):420-5. PMID: 26797373.
      View in: PubMed
    18. Hoang JK, Reiman RE, Nguyen GB, Januzis N, Chin BB, Lowry C, Yoshizumi TT. Lifetime Attributable Risk of Cancer From Radiation Exposure During Parathyroid Imaging: Comparison of 4D CT and Parathyroid Scintigraphy. AJR Am J Roentgenol. 2015 May; 204(5):W579-85. PMID: 25905965.
      View in: PubMed
    19. Zhang T, Dhawan MS, Healy P, George DJ, Harrison MR, Oldan J, Chin B, Armstrong AJ. Exploring the Clinical Benefit of Docetaxel or Enzalutamide After Disease Progression During Abiraterone Acetate and Prednisone Treatment in Men With Metastatic Castration-Resistant Prostate Cancer. Clin Genitourin Cancer. 2015 Aug; 13(4):392-399. PMID: 25708161.
      View in: PubMed
    20. Chin BB, Kronauge JF, Femia FJ, Chen J, Maresca KP, Hillier S, Petry NA, James OG, Oldan JD, Armor T, Stubbs JB, Stabin MG, Babich JW. Phase-1 clinical trial results of high-specific-activity carrier-free 123I-iobenguane. J Nucl Med. 2014 May; 55(5):765-71. PMID: 24627436.
      View in: PubMed
    21. Chin BB, Hjelemand A, Rich J, Song H, Lascola C, Storms R, McLendon R, Reiman R, Greer KL, Metzler SD, McDougald D, Dai D, Vaidyanathan G. Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression. Curr Radiopharm. 2012 Jan; 5(1):47-58. PMID: 21864242.
      View in: PubMed
    22. Vaidyanathan G, McDougald D, Grasfeder L, Zalutsky MR, Chin B. An alternative and expedient synthesis of radioiodinated 4-iodophenylalanine. Appl Radiat Isot. 2011 Oct; 69(10):1401-6. PMID: 21621415.
      View in: PubMed
    23. Vaidyanathan G, Song H, Affleck D, McDougald DL, Storms RW, Zalutsky MR, Chin BB. Targeting aldehyde dehydrogenase: a potential approach for cell labeling. Nucl Med Biol. 2009 Nov; 36(8):919-29. PMID: 19875048.
      View in: PubMed
    24. Metzler SD, Vemulapalli S, Jaszczak RJ, Akabani G, Chin BB. Feasibility of whole-body functional mouse imaging using helical pinhole SPECT. Mol Imaging Biol. 2010 Jan-Feb; 12(1):35-41. PMID: 19521736.
      View in: PubMed
    25. Chin BB, Green ED, Turkington TG, Hawk TC, Coleman RE. Increasing uptake time in FDG-PET: standardized uptake values in normal tissues at 1 versus 3 h. Mol Imaging Biol. 2009 Mar-Apr; 11(2):118-22. PMID: 19037614.
      View in: PubMed
    26. Chin BB, Metzler SD, Lemaire A, Curcio A, Vemulapalli S, Greer KL, Petry NA, Turkington TG, Coleman RE, Rockman H, Jaszczak RJ. Left ventricular functional assessment in mice: feasibility of high spatial and temporal resolution ECG-gated blood pool SPECT. Radiology. 2007 Nov; 245(2):440-8. PMID: 17940303.
      View in: PubMed
    27. Vemulapalli S, Metzler SD, Akabani G, Petry NA, Niehaus NJ, Liu X, Patil NH, Greer KL, Jaszczak RJ, Coleman RE, Dong C, Goldschmidt-Clermont PJ, Chin BB. Cell therapy in murine atherosclerosis: in vivo imaging with high-resolution helical SPECT. Radiology. 2007 Jan; 242(1):198-207. PMID: 17185668.
      View in: PubMed
    28. Chin BB, Chang PP. Gastrointestinal malignancies evaluated with (18)F-fluoro-2-deoxyglucose positron emission tomography. Best Pract Res Clin Gastroenterol. 2006 Feb; 20(1):3-21. PMID: 16473798.
      View in: PubMed
    29. Metzler SD, Jaszczak RJ, Patil NH, Vemulapalli S, Akabani G, Chin BB. Molecular imaging of small animals with a triple-head SPECT system using pinhole collimation. IEEE Trans Med Imaging. 2005 Jul; 24(7):853-62. PMID: 16011314.
      View in: PubMed
    30. Jacene HA, Patel PP, Chin BB. 2-Deoxy-2-[18F] fluoro-D-glucose uptake in intercostal respiratory muscles on positron emission tomography/computed tomography: smokers versus nonsmokers. Mol Imaging Biol. 2004 Nov-Dec; 6(6):405-10. PMID: 15564151.
      View in: PubMed
    31. Lee JM, Zemans RL, Hejazi M, Chin BB, Ladenson PW, Caturegli P. Modulation of thyroidal radioiodine uptake by theophylline. Exp Mol Pathol. 2004 Oct; 77(2):116-20. PMID: 15351234.
      View in: PubMed
    32. Nakamoto Y, Chin BB, Cohade C, Osman M, Tatsumi M, Wahl RL. PET/CT: artifacts caused by bowel motion. Nucl Med Commun. 2004 Mar; 25(3):221-5. PMID: 15094438.
      View in: PubMed
    33. Chin BB, Patel P, Cohade C, Ewertz M, Wahl R, Ladenson P. Recombinant human thyrotropin stimulation of fluoro-D-glucose positron emission tomography uptake in well-differentiated thyroid carcinoma. J Clin Endocrinol Metab. 2004 Jan; 89(1):91-5. PMID: 14715833.
      View in: PubMed
    34. Chin BB, Patel P, Hammoud D. Combined positron emission tomography - computed tomography improves specificity for thyroid carcinoma by identifying vocal cord activity after laryngeal nerve paralysis. Thyroid. 2003 Dec; 13(12):1183-4. PMID: 14751041.
      View in: PubMed
    35. Chin BB, Nakamoto Y, Bulte JW, Pittenger MF, Wahl R, Kraitchman DL. 111In oxine labelled mesenchymal stem cell SPECT after intravenous administration in myocardial infarction. Nucl Med Commun. 2003 Nov; 24(11):1149-54. PMID: 14569169.
      View in: PubMed
    36. Iyengar S, Chin B, Margolick JB, Sabundayo BP, Schwartz DH. Anatomical loci of HIV-associated immune activation and association with viraemia. Lancet. 2003 Sep 20; 362(9388):945-50. PMID: 14511927.
      View in: PubMed
    37. Nakamoto Y, Chin BB, Kraitchman DL, Lawler LP, Marshall LT, Wahl RL. Effects of nonionic intravenous contrast agents at PET/CT imaging: phantom and canine studies. Radiology. 2003 Jun; 227(3):817-24. PMID: 12773683.
      View in: PubMed
    38. Chin BB, Wahl RL. 18F-Fluoro-2-deoxyglucose positron emission tomography in the evaluation of gastrointestinal malignancies. Gut. 2003 Jun; 52 Suppl 4:iv23-9. PMID: 12746265.
      View in: PubMed
    39. Chin BB, Nakamoto Y, Kraitchman DL, Marshall L, Wahl R. PET-CT evaluation of 2-deoxy-2-[18F]fluoro-D-glucose myocardial uptake: effect of respiratory motion. Mol Imaging Biol. 2003 Mar-Apr; 5(2):57-64. PMID: 14499145.
      View in: PubMed
    40. Patel PV, Cohade C, Chin BB. PET-CT localizes previously undetectable metastatic lesions in recurrent fallopian tube carcinoma. Gynecol Oncol. 2002 Dec; 87(3):323-6. PMID: 12468334.
      View in: PubMed
    41. Chin BB, Patel PV, Nakamoto Y, Cohade C, Osman M, Marshall LT, Wahl RL. Quantitative evaluation of 2-deoxy-2-[18F] fluoro-D-glucose uptake in hepatic metastases with combined PET-CT: iterative reconstruction with CT attenuation correction versus filtered back projection with 68Germanium attenuation correction. Mol Imaging Biol. 2002 Nov; 4(6):399-409. PMID: 14537104.
      View in: PubMed
    42. Gerber BL, Bluemke DA, Chin BB, Boston RC, Heldman AW, Lima JA, Kraitchman DL. Single-vessel coronary artery stenosis: myocardial perfusion imaging with Gadomer-17 first-pass MR imaging in a swine model of comparison with gadopentetate dimeglumine. Radiology. 2002 Oct; 225(1):104-12. PMID: 12354992.
      View in: PubMed
    43. Chin BB, Lyengar S, Sabundayo BP, Schwartz D. Standardized Uptake Values in 2-Deoxy-2-[18F]Fluoro-D-Glucose with Positron Emission Tomography. Clinical Significance of Iterative Reconstruction and Segmented Attenuation Compared with Conventional Filtered Back Projection and Measured Attenuation Correction. Mol Imaging Biol. 2002 Jul; 4(4):294-300. PMID: 14537120.
      View in: PubMed
    44. Bluemke DA, Kraitchman DL, Heldman A, Chin BB, Steinert C. Optimal characterization of myocardial perfusion with AngioMARK. Acad Radiol. 2002 May; 9 Suppl 1:S78. PMID: 12019902.
      View in: PubMed
    45. Chin BB, Esposito G, Kraitchman DL. Myocardial contractile reserve and perfusion defect severity with rest and stress dobutamine (99m)Tc-sestamibi SPECT in canine stunning and subendocardial infarction. J Nucl Med. 2002 Apr; 43(4):540-50. PMID: 11937600.
      View in: PubMed
    46. Kraitchman DL, Chin BB, Heldman AW, Solaiyappan M, Bluemke DA. MRI detection of myocardial perfusion defects due to coronary artery stenosis with MS-325. J Magn Reson Imaging. 2002 Feb; 15(2):149-58. PMID: 11836770.
      View in: PubMed
    47. Kraitchman DL, Bluemke DA, Chin BB, Heldman AW, Heldman AW. A minimally invasive method for creating coronary stenosis in a swine model for MRI and SPECT imaging. Invest Radiol. 2000 Jul; 35(7):445-51. PMID: 10901107.
      View in: PubMed
    48. Port JD, Miseljic S, Lee RR, Ali SZ, Nicol TL, Royal W, Chin BB. Progressive multifocal leukoencephalopathy demonstrating contrast enhancement on MRI and uptake of thallium-201: a case report. Neuroradiology. 1999 Dec; 41(12):895-8. PMID: 10639663.
      View in: PubMed
    49. Welsh JS, Yanez MH, Chin BB, Howard SP. Indium-111 capromab pendetide (ProstaScint) images before and after salvage radiation therapy. Clin Nucl Med. 1999 Dec; 24(12):983. PMID: 10595485.
      View in: PubMed
    50. Lin K, Szabo Z, Chin BB, Civelek AC. The value of a baseline bone scan in patients with newly diagnosed prostate cancer. Clin Nucl Med. 1999 Aug; 24(8):579-82. PMID: 10439178.
      View in: PubMed
    51. Chin BB, Welsh JS, Kleinberg L, Ettinger D, White P. Nonsegmental ventilation-perfusion scintigraphy mismatch after radiation therapy. Clin Nucl Med. 1999 Jan; 24(1):54-6. PMID: 9890495.
      View in: PubMed
    52. Lin K, Nguyen BD, Ettinger DS, Chin BB. Somatostatin receptor scintigraphy and somatostatin therapy in the evaluation and treatment of malignant thymoma. Clin Nucl Med. 1999 Jan; 24(1):24-8. PMID: 9890489.
      View in: PubMed
    53. Beall DP, Martin D, Chin BB. Decreased bilateral frontal lobe perfusion in dementia of amyotrophic lateral sclerosis. Clin Nucl Med. 1998 Dec; 23(12):855-6. PMID: 9858308.
      View in: PubMed
    54. Nguyen BD, Chin BB, Beall DP. Gardner's syndrome with bone scintigraphic and CT demonstration. Clin Nucl Med. 1998 Apr; 23(4):234-5. PMID: 9554197.
      View in: PubMed
    55. Nguyen BD, Chin BB, Lugo-Olivieri CH. Tc-99m sestamibi scintigraphy of double parathyroid adenoma. Clin Nucl Med. 1997 Dec; 22(12):856. PMID: 9408653.
      View in: PubMed
    56. Chin BB, Nguyen BD. Retroperitoneal hemorrhage detected by RBC scintigraphy. Clin Nucl Med. 1997 Dec; 22(12):867-8. PMID: 9408661.
      View in: PubMed
    57. Nguyen BD, Chin BB, Beall DP. In-111 pentetreotide SPECT imaging of carcinoid tumor of the duodenum. Clin Nucl Med. 1997 Nov; 22(11):781-2. PMID: 9363392.
      View in: PubMed
    58. Chin BB, Civelek AC, Mudun A. Resting Tl-201 scintigraphy in the evaluation of myocardial sarcoidosis. Clin Nucl Med. 1997 Jul; 22(7):475-8. PMID: 9227871.
      View in: PubMed
    59. Chin BB, Bloomgarden DC, Xia W, Kim HJ, Fayad ZA, Ferrari VA, Berlin JA, Axel L, Alavi A. Right and left ventricular volume and ejection fraction by tomographic gated blood-pool scintigraphy. J Nucl Med. 1997 Jun; 38(6):942-8. PMID: 9189147.
      View in: PubMed
    60. Bloomgarden DC, Fayad ZA, Ferrari VA, Chin B, Sutton MG, Axel L. Global cardiac function using fast breath-hold MRI: validation of new acquisition and analysis techniques. Magn Reson Med. 1997 May; 37(5):683-92. PMID: 9126942.
      View in: PubMed
    61. Nguyen BD, Chin BB, Imperial AJ. Tc-99m sestamibi SPECT imaging of a retroesophageal parathyroid adenoma. Clin Nucl Med. 1996 Nov; 21(11):880. PMID: 8922853.
      View in: PubMed
    62. Chin BB, Moshin J, Bouchard M, Berlin JA, Araujo LI, Alavi A. Hemodynamic indices of myocardial dysfunction correlate with dipyridamole thallium-201 SPECT. J Nucl Med. 1996 May; 37(5):723-9. PMID: 8965134.
      View in: PubMed
    63. Chin BB, Kim HJ, Zukerberg B, Alavi A. Gated resting Tl-201 SPECT in the evaluation of myocardial viability. Clin Nucl Med. 1996 Apr; 21(4):275-9. PMID: 8925605.
      View in: PubMed
    64. Chin BB, Zukerberg BW, Buchpiguel C, Alavi A. Thallium-201 uptake in lung cancer. J Nucl Med. 1995 Aug; 36(8):1514-9. PMID: 7629600.
      View in: PubMed
    65. Civelek AC, Sitzmann JV, Chin BB, Venbrux A, Wagner HN, Grochow LB. Misperfusion of the liver during hepatic artery infusion chemotherapy: value of preoperative angiography and postoperative pump scintigraphy. AJR Am J Roentgenol. 1993 Apr; 160(4):865-70. PMID: 8456683.
      View in: PubMed
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