 Nuclear Receptor Subfamily 4, Group A, Member 1
"Nuclear Receptor Subfamily 4, Group A, Member 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An orphan nuclear receptor that is closely related to members of the thyroid-steroid receptor gene family. It was originally identified in NERVE CELLS and may play a role in mediation of NERVE GROWTH FACTOR-induced CELL DIFFERENTIATION. However, several other functions have been attributed to this protein including the positive and negative regulation of APOPTOSIS.
| Descriptor ID |
D057105
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| MeSH Number(s) |
D12.776.260.643.400 D12.776.826.209.400
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| Concept/Terms |
Nuclear Receptor Subfamily 4, Group A, Member 1- Nuclear Receptor Subfamily 4, Group A, Member 1
- Nerve Growth Factor-inducible B Protein
- Nerve Growth Factor inducible B Protein
- Orphan Nuclear Receptor HMR
- Orphan Nuclear Receptor NGFI-B
- Orphan Nuclear Receptor NGFI B
- Orphan Nuclear Receptor NR4A1
- Nuclear Receptor NR4A1
- TR3 Orphan Nuclear Receptor
- Nur77 Orphan Nuclear Receptor
- NGFI-B Orphan Nuclear Receptor
- NGFI B Orphan Nuclear Receptor
- Early Response Protein NAK1
- Orphan Nuclear Receptor TR3
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Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Subfamily 4, Group A, Member 1".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Subfamily 4, Group A, Member 1".
This graph shows the total number of publications written about "Nuclear Receptor Subfamily 4, Group A, Member 1" by people in this website by year, and whether "Nuclear Receptor Subfamily 4, Group A, Member 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nuclear Receptor Subfamily 4, Group A, Member 1" by people in Profiles.
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Cartwright IM, Dowdell AS, Lanis JM, Brink KR, Mu A, Kostelecky RE, Schaefer REM, Welch N, Onyiah JC, Hall CHT, Gerich ME, Tabor JJ, Colgan SP. Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation. Proc Natl Acad Sci U S A. 2021 05 18; 118(20).
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Popichak KA, Hammond SL, Moreno JA, Afzali MF, Backos DS, Slayden RD, Safe S, Tjalkens RB. Compensatory Expression of Nur77 and Nurr1 Regulates NF-?B-Dependent Inflammatory Signaling in Astrocytes. Mol Pharmacol. 2018 10; 94(4):1174-1186.
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Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, V?lkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Sch?fer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londo?o JEC, Meder B, Freichel M, Gr?ne HJ, Most P, M?ller OJ, Herzig S, Furlong EEM, Katus HA, Backs J. A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway. Nat Med. 2018 01; 24(1):62-72.
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Delgado E, Boisen MM, Laskey R, Chen R, Song C, Sallit J, Yochum ZA, Andersen CL, Sikora MJ, Wagner J, Safe S, Elishaev E, Lee A, Edwards RP, Haluska P, Tseng G, Schurdak M, Oesterreich S. High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecol Oncol. 2016 05; 141(2):348-356.
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Lee SO, Li X, Hedrick E, Jin UH, Tjalkens RB, Backos DS, Li L, Zhang Y, Wu Q, Safe S. Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells. Mol Endocrinol. 2014 Oct; 28(10):1729-39.
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Kirchenbaum GA, St Clair JB, Detanico T, Aviszus K, Wysocki LJ. Functionally responsive self-reactive B cells of low affinity express reduced levels of surface IgM. Eur J Immunol. 2014 Apr; 44(4):970-82.
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Mohan HM, Aherne CM, Rogers AC, Baird AW, Winter DC, Murphy EP. Molecular pathways: the role of NR4A orphan nuclear receptors in cancer. Clin Cancer Res. 2012 Jun 15; 18(12):3223-8.
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Pace TW, Gaylord RI, Jarvis E, Girotti M, Spencer RL. Differential glucocorticoid effects on stress-induced gene expression in the paraventricular nucleus of the hypothalamus and ACTH secretion in the rat. Stress. 2009 Sep; 12(5):400-11.
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Ahn SW, Nedumaran B, Xie Y, Kim DK, Kim YD, Choi HS. Bisphenol A bis(2,3-dihydroxypropyl) ether (BADGE.2H2O) induces orphan nuclear receptor Nur77 gene expression and increases steroidogenesis in mouse testicular Leydig cells. Mol Cells. 2008 Jul 31; 26(1):74-80.
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Girotti M, Weinberg MS, Spencer RL. Differential responses of hypothalamus-pituitary-adrenal axis immediate early genes to corticosterone and circadian drive. Endocrinology. 2007 May; 148(5):2542-52.
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