 Nod1 Signaling Adaptor Protein
"Nod1 Signaling Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A NOD-signaling adaptor protein that contains a C-terminal leucine-rich domain which recognizes bacterial PEPTIDOGLYCAN. It signals via an N-terminal caspase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. It plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM.
| Descriptor ID |
D053474
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| MeSH Number(s) |
D12.644.360.024.131.249 D12.644.360.024.313.249 D12.644.360.075.358.249 D12.644.360.539.500.249 D12.776.157.057.006.249 D12.776.157.057.078.249 D12.776.476.024.139.249 D12.776.476.024.391.249 D12.776.476.075.358.249
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| Concept/Terms |
Nod1 Signaling Adaptor Protein- Nod1 Signaling Adaptor Protein
- Caspase Recruitment Domain Protein 4
- Nucleotide Oligomerization Domain 1 Protein
- CARD4 Protein
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Below are MeSH descriptors whose meaning is more general than "Nod1 Signaling Adaptor Protein".
Below are MeSH descriptors whose meaning is more specific than "Nod1 Signaling Adaptor Protein".
This graph shows the total number of publications written about "Nod1 Signaling Adaptor Protein" by people in this website by year, and whether "Nod1 Signaling Adaptor Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2013 | 2 | 0 | 2 | | 2014 | 0 | 1 | 1 | | 2016 | 2 | 0 | 2 | | 2017 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 2 | 0 | 2 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nod1 Signaling Adaptor Protein" by people in Profiles.
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Sweet LA, Kuss-Duerkop SK, Keestra-Gounder AM. IRE1a-Driven Inflammation Promotes Clearance of Citrobacter rodentium Infection. Infect Immun. 2022 01 25; 90(1):e0048121.
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Kuss-Duerkop SK, Keestra-Gounder AM. NOD1 and NOD2 Activation by Diverse Stimuli: a Possible Role for Sensing Pathogen-Induced Endoplasmic Reticulum Stress. Infect Immun. 2020 06 22; 88(7).
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Pham OH, Lee B, Labuda J, Keestra-Gounder AM, Byndloss MX, Tsolis RM, McSorley SJ. NOD1/NOD2 and RIP2 Regulate Endoplasmic Reticulum Stress-Induced Inflammation during Chlamydia Infection. mBio. 2020 06 02; 11(3).
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Mendez JM, Kolora LD, Lemon JS, Dupree SL, Keestra-Gounder AM. Activation of the Endoplasmic Reticulum Stress Response Impacts the NOD1 Signaling Pathway. Infect Immun. 2019 08; 87(8).
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Schmolka N, Papotto PH, Romero PV, Amado T, Enguita FJ, Amorim A, Rodrigues AF, Gordon KE, Coroadinha AS, Boldin M, Serre K, Buck AH, Gomes AQ, Silva-Santos B. MicroRNA-146a controls functional plasticity in ?d T cells by targeting NOD1. Sci Immunol. 2018 05 04; 3(23).
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Keestra-Gounder AM, Tsolis RM. NOD1 and NOD2: Beyond Peptidoglycan Sensing. Trends Immunol. 2017 10; 38(10):758-767.
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Byndloss MX, Keestra-Gounder AM, B?umler AJ, Tsolis RM. NOD1 and NOD2: New Functions Linking Endoplasmic Reticulum Stress and Inflammation. DNA Cell Biol. 2016 Jul; 35(7):311-3.
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Keestra-Gounder AM, Byndloss MX, Seyffert N, Young BM, Ch?vez-Arroyo A, Tsai AY, Cevallos SA, Winter MG, Pham OH, Tiffany CR, de Jong MF, Kerrinnes T, Ravindran R, Luciw PA, McSorley SJ, B?umler AJ, Tsolis RM. NOD1 and NOD2 signalling links ER stress with inflammation. Nature. 2016 Apr 21; 532(7599):394-7.
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Leissinger M, Kulkarni R, Zemans RL, Downey GP, Jeyaseelan S. Investigating the role of nucleotide-binding oligomerization domain-like receptors in bacterial lung infection. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1461-8.
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Keestra AM, B?umler AJ. Detection of enteric pathogens by the nodosome. Trends Immunol. 2014 Mar; 35(3):123-30.
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