 Nod2 Signaling Adaptor Protein
"Nod2 Signaling Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.
| Descriptor ID |
D053473
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| MeSH Number(s) |
D12.644.360.024.131.500 D12.644.360.024.313.500 D12.644.360.075.358.500 D12.644.360.539.500.500 D12.776.157.057.006.500 D12.776.157.057.078.500 D12.776.476.024.139.500 D12.776.476.024.391.500 D12.776.476.075.358.500
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| Concept/Terms |
Nod2 Signaling Adaptor Protein- Nod2 Signaling Adaptor Protein
- CARD15 Protein
- Nucleotide Oligomerization Domain 2 Protein
- Caspase Recruitment Domain Protein 15
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Below are MeSH descriptors whose meaning is more general than "Nod2 Signaling Adaptor Protein".
Below are MeSH descriptors whose meaning is more specific than "Nod2 Signaling Adaptor Protein".
This graph shows the total number of publications written about "Nod2 Signaling Adaptor Protein" by people in this website by year, and whether "Nod2 Signaling Adaptor Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 2 | 0 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 1 | 2 | | 2013 | 1 | 2 | 3 | | 2014 | 0 | 1 | 1 | | 2016 | 2 | 0 | 2 | | 2017 | 1 | 1 | 2 | | 2019 | 0 | 1 | 1 | | 2020 | 2 | 0 | 2 | | 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Nod2 Signaling Adaptor Protein" by people in Profiles.
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Sweet LA, Kuss-Duerkop SK, Keestra-Gounder AM. IRE1a-Driven Inflammation Promotes Clearance of Citrobacter rodentium Infection. Infect Immun. 2022 01 25; 90(1):e0048121.
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Villarreal R, Manzer HS, Keestra-Gounder AM, Doran KS. Vimentin Regulates Chemokine Expression and NOD2 Activation in Brain Endothelium during Group B Streptococcal Infection. Infect Immun. 2021 11 16; 89(12):e0034021.
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Kuss-Duerkop SK, Keestra-Gounder AM. NOD1 and NOD2 Activation by Diverse Stimuli: a Possible Role for Sensing Pathogen-Induced Endoplasmic Reticulum Stress. Infect Immun. 2020 06 22; 88(7).
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Pham OH, Lee B, Labuda J, Keestra-Gounder AM, Byndloss MX, Tsolis RM, McSorley SJ. NOD1/NOD2 and RIP2 Regulate Endoplasmic Reticulum Stress-Induced Inflammation during Chlamydia Infection. mBio. 2020 06 02; 11(3).
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Li E, Zhang Y, Tian X, Wang X, Gathungu G, Wolber A, Shiekh SS, Sartor RB, Davidson NO, Ciorba MA, Zhu W, Nelson LM, Robertson CE, Frank DN. Influence of Crohn's disease related polymorphisms in innate immune function on ileal microbiome. PLoS One. 2019; 14(2):e0213108.
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Keestra-Gounder AM, Tsolis RM. NOD1 and NOD2: Beyond Peptidoglycan Sensing. Trends Immunol. 2017 10; 38(10):758-767.
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Ahmad M, Hermanson ME, Enzenauer R, Palestine A, Lin C, Meeks N, McCourt E. Lipogranulomatous subconjunctival nodules: a novel presentation in Blau syndrome. J AAPOS. 2017 Jun; 21(3):249-251.
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Byndloss MX, Keestra-Gounder AM, B?umler AJ, Tsolis RM. NOD1 and NOD2: New Functions Linking Endoplasmic Reticulum Stress and Inflammation. DNA Cell Biol. 2016 Jul; 35(7):311-3.
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Keestra-Gounder AM, Byndloss MX, Seyffert N, Young BM, Ch?vez-Arroyo A, Tsai AY, Cevallos SA, Winter MG, Pham OH, Tiffany CR, de Jong MF, Kerrinnes T, Ravindran R, Luciw PA, McSorley SJ, B?umler AJ, Tsolis RM. NOD1 and NOD2 signalling links ER stress with inflammation. Nature. 2016 Apr 21; 532(7599):394-7.
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Leissinger M, Kulkarni R, Zemans RL, Downey GP, Jeyaseelan S. Investigating the role of nucleotide-binding oligomerization domain-like receptors in bacterial lung infection. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1461-8.
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