 Apoptotic Protease-Activating Factor 1
"Apoptotic Protease-Activating Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.
| Descriptor ID |
D053477
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| MeSH Number(s) |
D12.644.360.024.131.124 D12.644.360.075.358.124 D12.776.157.057.006.124 D12.776.476.024.139.124 D12.776.476.075.358.124
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| Concept/Terms |
Apoptotic Protease-Activating Factor 1- Apoptotic Protease-Activating Factor 1
- Apoptotic Protease Activating Factor 1
- Apaf-1 Protease-Activating Factor
- Apaf 1 Protease Activating Factor
- Protease-Activating Factor, Apaf-1
- Apoptotic Peptidase Activating Factor 1
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Below are MeSH descriptors whose meaning is more general than "Apoptotic Protease-Activating Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Apoptotic Protease-Activating Factor 1".
This graph shows the total number of publications written about "Apoptotic Protease-Activating Factor 1" by people in this website by year, and whether "Apoptotic Protease-Activating Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Apoptotic Protease-Activating Factor 1" by people in Profiles.
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Amin Z, Kanarek K, Krupitsky E, Walderhaug E, Ilom?ki R, Blumberg H, Price LH, Bhagwagar Z, Carpenter LL, Tyrka AR, Magnusson A, Landr? NI, Zvartau E, Gelernter J, Epperson CN, R?s?nen P, Siironen J, Lappalainen J. A sequencing-based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controls. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 05; 153B(1):332-5.
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Yang S, Liu J, Thor AD, Yang X. Caspase expression profile and functional activity in a panel of breast cancer cell lines. Oncol Rep. 2007 May; 17(5):1229-35.
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