 Dioxygenases
"Dioxygenases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS.
| Descriptor ID |
D049308
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| MeSH Number(s) |
D08.811.682.690.416
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dioxygenases".
Below are MeSH descriptors whose meaning is more specific than "Dioxygenases".
This graph shows the total number of publications written about "Dioxygenases" by people in this website by year, and whether "Dioxygenases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 | | 2000 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2010 | 1 | 1 | 2 | | 2011 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2017 | 0 | 2 | 2 | | 2018 | 0 | 1 | 1 | | 2020 | 1 | 4 | 5 | | 2021 | 2 | 0 | 2 | | 2022 | 4 | 0 | 4 | | 2024 | 1 | 2 | 3 |
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Below are the most recent publications written about "Dioxygenases" by people in Profiles.
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Lee SCS, Pyo AHA, Mohammadi H, Zhang J, Dvorkin-Gheva A, Malbeteau L, Chung S, Khan S, Ciudad MT, Rondeau V, Cairns RA, Kislinger T, McGaha TL, Wouters BG, Reisz JA, Culp-Hill R, D'Alessandro A, Jones CL, Koritzinsky M. Cysteamine dioxygenase (ADO) governs cancer cell mitochondrial redox homeostasis through proline metabolism. Sci Adv. 2024 Oct 04; 10(40):eadq0355.
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Del Rio Flores A, Zhai R, Zhang W. Isonitrile biosynthesis by non-heme iron(II)-dependent oxidases/decarboxylases. Methods Enzymol. 2024; 704:143-172.
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Becht DC, Mohid SA, Lee JE, Zandian M, Benz C, Biswas S, Sinha VK, Ivarsson Y, Ge K, Zhang Y, Kutateladze TG. MLL4 binds TET3. Structure. 2024 06 06; 32(6):706-714.e3.
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Pietras EM, DeGregori J. Dangerous Liaisons between Tet2 Mutation, Inflammatory Monocytes, and Leukemogenesis. Cancer Discov. 2022 10 05; 12(10):2234-2236.
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Schleicher WE, Pietras EM. Reduced PU.1 Expression Collaborates with Tet2 Loss to Trigger Myeloid Leukemogenesis. Blood Cancer Discov. 2022 09 06; 3(5):378-381.
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Kincannon WM, Zahn M, Clare R, Lusty Beech J, Romberg A, Larson J, Bothner B, Beckham GT, McGeehan JE, DuBois JL. Biochemical and structural characterization of an aromatic ring-hydroxylating dioxygenase for terephthalic acid catabolism. Proc Natl Acad Sci U S A. 2022 03 29; 119(13):e2121426119.
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Armstrong N, Storey CM, Noll SE, Margulis K, Soe MH, Xu H, Yeh B, Fishbein L, Kebebew E, Howitt BE, Zare RN, Sage J, Annes JP. SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas. Cell Rep. 2022 03 01; 38(9):110453.
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Kuatsjah E, Chan ACK, Katahira R, Haugen SJ, Beckham GT, Murphy MEP, Eltis LD. Structural and functional analysis of lignostilbene dioxygenases from Sphingobium sp. SYK-6. J Biol Chem. 2021 Jan-Jun; 296:100758.
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Wu L, Lu P, Guo X, Song K, Lyu Y, Bothwell J, Wu J, Hawkins O, Clarke SL, Lucas EA, Smith BJ, Chowanadisai W, Hartson SD, Ritchey JW, Wang W, Medeiros DM, Li S, Lin D. ß-carotene oxygenase 2 deficiency-triggered mitochondrial oxidative stress promotes low-grade inflammation and metabolic dysfunction. Free Radic Biol Med. 2021 02 20; 164:271-284.
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Jonnalagadda R, Del Rio Flores A, Cai W, Mehmood R, Narayanamoorthy M, Ren C, Zaragoza JPT, Kulik HJ, Zhang W, Drennan CL. Biochemical and crystallographic investigations into isonitrile formation by a nonheme iron-dependent oxidase/decarboxylase. J Biol Chem. 2021 Jan-Jun; 296:100231.
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