 Jumonji Domain-Containing Histone Demethylases
"Jumonji Domain-Containing Histone Demethylases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of histone demethylases that share a conserved Jumonji C domain. The enzymes function via an iron-dependent dioxygenase mechanism that couples the conversion of 2-oxoglutarate to succinate to the hydroxylation of N-methyl groups.
| Descriptor ID |
D056484
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| MeSH Number(s) |
D08.811.682.662.582.475.500 D08.811.682.690.416.388
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Jumonji Domain-Containing Histone Demethylases".
Below are MeSH descriptors whose meaning is more specific than "Jumonji Domain-Containing Histone Demethylases".
This graph shows the total number of publications written about "Jumonji Domain-Containing Histone Demethylases" by people in this website by year, and whether "Jumonji Domain-Containing Histone Demethylases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2007 | 0 | 2 | 2 | | 2010 | 2 | 0 | 2 | | 2011 | 1 | 1 | 2 | | 2013 | 3 | 0 | 3 | | 2014 | 1 | 1 | 2 | | 2015 | 3 | 1 | 4 | | 2016 | 0 | 2 | 2 | | 2017 | 5 | 0 | 5 | | 2018 | 1 | 0 | 1 | | 2019 | 2 | 2 | 4 | | 2020 | 3 | 1 | 4 | | 2021 | 1 | 1 | 2 | | 2024 | 1 | 2 | 3 | | 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Jumonji Domain-Containing Histone Demethylases" by people in Profiles.
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Rosas R, Baracaldo-Lancheros LF, Dykhuizen EC, Musselman CA. Structural landscape of H3K27me3 recognition by protein domains and their potential for inhibition. J Biol Chem. 2026 Apr; 302(4):111344.
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Hsieh J, Danis EP, Owens CR, Parrish JK, Nowling NL, Wolin AR, Purdy SC, Rosenbaum SR, Ivancevic AM, Chuong EB, Ford HL, Jedlicka P. Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive Rhabdomyosarcoma. Oncogene. 2025 01; 44(1):19-29.
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Glover L, Lilly AG, Justice AE, Howard AG, Staley BS, Wang Y, Kamens HM, Ferrier K, Bressler J, Loehr L, Raffield LM, Sims M, North KE, Fernández-Rhodes L. DNA methylation near MAD1L1, KDM2B, and SOCS3 mediates the effect of socioeconomic status on elevated body mass index in African American adults. Hum Mol Genet. 2024 10 07; 33(20):1748-1757.
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Affandi T, Haas A, Ohm AM, Wright GM, Black JC, Reyland ME. PKCd Regulates Chromatin Remodeling and DNA Repair through SIRT6. Mol Cancer Res. 2024 02 01; 22(2):181-196.
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Van Rechem C, Ji F, Chakraborty D, Black JC, Sadreyev RI, Whetstine JR. Collective regulation of chromatin modifications predicts replication timing during cell cycle. Cell Rep. 2021 10 05; 37(1):109799.
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Dahl NA, Donson AM, Sanford B, Wang D, Walker FM, Gilani A, Foreman NK, Tinkle CL, Baker SJ, Hoffman LM, Venkataraman S, Vibhakar R. NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas. J Neuropathol Exp Neurol. 2021 03 22; 80(4):345-353.
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Riching AS, Danis E, Zhao Y, Cao Y, Chi C, Bagchi RA, Klein BJ, Xu H, Kutateladze TG, McKinsey TA, Buttrick PM, Song K. Suppression of canonical TGF-ß signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis. J Mol Cell Cardiol. 2021 04; 153:44-59.
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Pribadi C, Camp E, Cakouros D, Anderson P, Glackin C, Gronthos S. Pharmacological targeting of KDM6A and KDM6B, as a novel therapeutic strategy for treating craniosynostosis in Saethre-Chotzen syndrome. Stem Cell Res Ther. 2020 12 09; 11(1):529.
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Van Rechem C, Ji F, Mishra S, Chakraborty D, Murphy SE, Dillingham ME, Sadreyev RI, Whetstine JR. The lysine demethylase KDM4A controls the cell-cycle expression of replicative canonical histone genes. Biochim Biophys Acta Gene Regul Mech. 2020 10; 1863(10):194624.
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Sobral LM, Hicks HM, Parrish JK, McCann TS, Hsieh J, Goodspeed A, Costello JC, Black JC, Jedlicka P. KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1-driven and independent disease-promoting gene expression in fusion-positive Rhabdomyosarcoma. Mol Oncol. 2020 10; 14(10):2471-2486.
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