 Proglucagon
"Proglucagon" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The common precursor polypeptide of pancreatic GLUCAGON and intestinal GLUCAGON-LIKE PEPTIDES. Proglucagon is the 158-amino acid segment of preproglucagon without the N-terminal signal sequence. Proglucagon is expressed in the PANCREAS; INTESTINES; and the CENTRAL NERVOUS SYSTEM. Posttranslational processing of proglucagon is tissue-specific yielding numerous bioactive peptides.
| Descriptor ID |
D052336
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| MeSH Number(s) |
D06.472.317.469 D06.472.699.587.469 D12.644.548.586.469 D12.776.811.700
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Proglucagon".
Below are MeSH descriptors whose meaning is more specific than "Proglucagon".
This graph shows the total number of publications written about "Proglucagon" by people in this website by year, and whether "Proglucagon" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2017 | 2 | 0 | 2 | | 2019 | 0 | 2 | 2 | | 2020 | 1 | 1 | 2 | | 2021 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proglucagon" by people in Profiles.
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Arble DM, Hutch CR, Hafner H, Stelmak D, Leix K, Sorrell J, Pressler JW, Gregg B, Sandoval DA. The role of preproglucagon peptides in regulating ?-cell morphology and responses to streptozotocin-induced diabetes. Am J Physiol Endocrinol Metab. 2023 03 01; 324(3):E217-E225.
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Bethea M, Bozadjieva-Kramer N, Sandoval DA. Preproglucagon Products and Their Respective Roles Regulating Insulin Secretion. Endocrinology. 2021 10 01; 162(10).
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Sandoval D. Updating the Role of a-Cell Preproglucagon Products on GLP-1 Receptor-Mediated Insulin Secretion. Diabetes. 2020 11; 69(11):2238-2245.
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Panaro BL, Yusta B, Matthews D, Koehler JA, Song Y, Sandoval DA, Drucker DJ. Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion. Mol Metab. 2020 07; 37:100990.
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Song Y, Koehler JA, Baggio LL, Powers AC, Sandoval DA, Drucker DJ. Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice. Cell Metab. 2019 11 05; 30(5):976-986.e3.
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Hutch CR, Roelofs K, Haller A, Sorrell J, Leix K, D'Alessio DD, Augustin R, Seeley RJ, Klein T, Sandoval DA. The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice. Diabetologia. 2019 10; 62(10):1928-1937.
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Wismann P, Barkholt P, Secher T, Vrang N, Hansen HB, Jeppesen PB, Baggio LL, Koehler JA, Drucker DJ, Sandoval DA, Jelsing J. The endogenous preproglucagon system is not essential for gut growth homeostasis in mice. Mol Metab. 2017 07; 6(7):681-692.
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Chambers AP, Sorrell JE, Haller A, Roelofs K, Hutch CR, Kim KS, Gutierrez-Aguilar R, Li B, Drucker DJ, D'Alessio DA, Seeley RJ, Sandoval DA. The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice. Cell Metab. 2017 Apr 04; 25(4):927-934.e3.
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D'Alessio DA, Sandoval DA, Seeley RJ. New ways in which GLP-1 can regulate glucose homeostasis. J Clin Invest. 2005 Dec; 115(12):3406-8.
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