 Islet Amyloid Polypeptide
"Islet Amyloid Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid secretion, gastric emptying and postprandial GLUCAGON secretion. Islet amyloid polypeptide can fold into AMYLOID FIBRILS that have been found as a major constituent of pancreatic AMYLOID DEPOSITS.
| Descriptor ID |
D058228
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| MeSH Number(s) |
D06.472.699.587.334 D12.644.548.586.234 D12.776.049.407.500
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| Concept/Terms |
Islet Amyloid Polypeptide- Islet Amyloid Polypeptide
- Amyloid Polypeptide, Islet
- Polypeptide, Islet Amyloid
- Pancreatic Amylin
- Amylin, Pancreatic
- IAPP Protein
- Insulinoma Amyloid Polypeptide
- Amyloid Polypeptide, Insulinoma
- Polypeptide, Insulinoma Amyloid
- Amlintide
- Amylin
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Below are MeSH descriptors whose meaning is more general than "Islet Amyloid Polypeptide".
Below are MeSH descriptors whose meaning is more specific than "Islet Amyloid Polypeptide".
This graph shows the total number of publications written about "Islet Amyloid Polypeptide" by people in this website by year, and whether "Islet Amyloid Polypeptide" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2013 | 1 | 1 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2020 | 2 | 0 | 2 | | 2021 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Islet Amyloid Polypeptide" by people in Profiles.
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Li W, Li R, Wang Y, Zhang Y, Tomar MS, Dai S. Calcitonin gene-related peptide is a potential autoantigen for CD4 T cells in type 1 diabetes. Front Immunol. 2022; 13:951281.
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Bubak AN, Beseler C, Como CN, Coughlan CM, Johnson NR, Hassell JE, Burnet AM, Mescher T, Schmid DS, Coleman C, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Shilleh AH, Russ HA, Nagel MA. Amylin, A?42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells. J Infect Dis. 2021 04 08; 223(7):1284-1294.
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Bubak AN, Beseler C, Como CN, Tyring SK, Haley C, Mescher T, Hassell JE, Cohrs RJ, Potter H, Nagel MA. Acute zoster plasma contains elevated amyloid, correlating with A?42 and amylin levels, and is amyloidogenic. J Neurovirol. 2020 06; 26(3):422-428.
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Bubak AN, Como CN, Coughlan CM, Johnson NR, Hassell JE, Mescher T, Niemeyer CS, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Russ HA, Nagel MA. Varicella-Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-?, and an Amyloidogenic Extracellular Environment. J Infect Dis. 2020 03 16; 221(7):1088-1097.
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Baker RL, Jamison BL, Wiles TA, Lindsay RS, Barbour G, Bradley B, Delong T, Friedman RS, Nakayama M, Haskins K. CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse. Diabetes. 2018 09; 67(9):1836-1846.
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Abedini A, Derk J, Schmidt AM. The receptor for advanced glycation endproducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and exploiting common ground for novel amyloidosis therapies. Protein Sci. 2018 07; 27(7):1166-1180.
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Abedini A, Cao P, Plesner A, Zhang J, He M, Derk J, Patil SA, Rosario R, Lonier J, Song F, Koh H, Li H, Raleigh DP, Schmidt AM. RAGE binds preamyloid IAPP intermediates and mediates pancreatic ? cell proteotoxicity. J Clin Invest. 2018 02 01; 128(2):682-698.
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Wiles TA, Delong T, Baker RL, Bradley B, Barbour G, Powell RL, Reisdorph N, Haskins K. An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse. J Autoimmun. 2017 03; 78:11-18.
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Viret C, Mahiddine K, Baker RL, Haskins K, Guerder S. The T Cell Repertoire-Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens. J Immunol. 2015 Sep 01; 195(5):1964-73.
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Garg SK, Michels AW, Shah VN. Use of non-insulin therapies for type 1 diabetes. Diabetes Technol Ther. 2013 Nov; 15(11):901-8.
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