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Darleen Ann Sandoval

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
    Collapse research activities and funding
    K26DK138368     (SANDOVAL, DARLEEN A.)Sep 1, 2023 - May 31, 2028
    NIH
    Training for minoritized individuals in gut-brain axis research
    Role: Principal Investigator
    R01DK121995     (PATTI, MARY E;SANDOVAL, DARLEEN A.)Jun 26, 2019 - May 31, 2024
    NIH
    Mechanisms of Post-Bariatric Hypoglycemia
    Role: Principal Investigator
    R01DK107282     (SANDOVAL, DARLEEN A.)Feb 1, 2017 - Jan 31, 2021
    NIH
    A novel paracrine role for GLP-1 in the islet
    Role: Principal Investigator
    R01DK082480     (SANDOVAL, DARLEEN A)Apr 15, 2010 - Feb 29, 2016
    NIH
    Role of Glucokinase in GLP-1 Regulation of Energy and Glucose Homeostasis
    Role: Principal Investigator
    K01DK075365     (SANDOVAL, DARLEEN A)Jul 1, 2006 - Jun 30, 2011
    NIH
    Novel Role for CNS GLP in Glucose Homeostasis
    Role: Principal Investigator
    F32DK065461     (SANDOVAL, DARLEEN A)Apr 1, 2004 - Jan 14, 2005
    NIH
    Exercise Associated Hypoglycemia in Diabetes Mellitus
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Qiu W, Hutch CR, Wang Y, Wloszek J, Rucker RA, Myers MG, Sandoval D. Multiple NTS neuron populations cumulatively suppress food intake. Elife. 2023 Dec 07; 12. PMID: 38059498.
      View in: PubMed
    2. Patel AR, Frikke-Schmidt H, Sabatini PV, Rupp AC, Sandoval DA, Myers MG, Seeley RJ. Neither GLP-1 receptors nor GFRAL neurons are required for aversive or anorectic response to DON (vomitoxin). Am J Physiol Regul Integr Comp Physiol. 2023 Mar 13. PMID: 36912475.
      View in: PubMed
    3. Arble DM, Hutch CR, Hafner H, Stelmak D, Leix K, Sorrell J, Pressler JW, Gregg B, Sandoval DA. The role of preproglucagon peptides in regulating ?-cell morphology and responses to streptozotocin-induced diabetes. Am J Physiol Endocrinol Metab. 2023 03 01; 324(3):E217-E225. PMID: 36652401.
      View in: PubMed
    4. Barnes JN, Burns JM, Bamman MM, Billinger SA, Bodine SC, Booth FW, Brassard P, Clemons TA, Fadel PJ, Geiger PC, Gujral S, Haus JM, Kanoski SE, Miller BF, Morris JK, O'Connell KMS, Poole DC, Sandoval DA, Smith JC, Swerdlow RH, Whitehead SN, Vidoni ED, van Praag H. Proceedings from the Albert Charitable Trust Inaugural Workshop on 'Understanding the Acute Effects of Exercise on the Brain'. Brain Plast. 2022; 8(2):153-168. PMID: 36721393.
      View in: PubMed
    5. Vollbrecht PJ, Nesbitt KM, Addis VM, Boulnemour KM, Micheli DA, Smith KB, Sandoval DA, Kennedy RT, Ferrario CR. Differential regulation of nucleus accumbens glutamate and GABA in obesity-prone and obesity-resistant rats. J Neurochem. 2023 02; 164(4):499-511. PMID: 36336816.
      View in: PubMed
    6. Sandoval DA, Patti ME. Glucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia. Nat Rev Endocrinol. 2023 03; 19(3):164-176. PMID: 36289368.
      View in: PubMed
    7. Shin JH, Bozadjieva-Kramer N, Shao Y, Lyons-Abbott S, Rupp AC, Sandoval DA, Seeley RJ. The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function. Cell Metab. 2022 11 01; 34(11):1765-1778.e6. PMID: 36240758.
      View in: PubMed
    8. Bethea M, Sandoval DA. Gut Factors Mediating the Physiological Impact of Bariatric Surgery. Curr Diab Rep. 2022 08; 22(8):371-383. PMID: 35723770.
      View in: PubMed
    9. Kim KS, Peck BC, Hung YH, Koch-Laskowski K, Wood L, Dedhia PH, Spence JR, Seeley RJ, Sethupathy P, Sandoval DA. Vertical sleeve gastrectomy induces enteroendocrine cell differentiation of intestinal stem cells through bile acid signaling. JCI Insight. 2022 06 08; 7(11). PMID: 35503251.
      View in: PubMed
    10. Kozuka C, Efthymiou V, Sales VM, Zhou L, Osataphan S, Yuchi Y, Chimene-Weiss J, Mulla C, Isganaitis E, Desmond J, Sanechika S, Kusuyama J, Goodyear L, Shi X, Gerszten RE, Aguayo-Mazzucato C, Carapeto P, Teixeira SD, Sandoval D, Alonso-Curbelo D, Wu L, Qi J, Patti ME. Bromodomain Inhibition Reveals FGF15/19 As a Target of Epigenetic Regulation and Metabolic Control. Diabetes. 2022 05 01; 71(5):1023-1033. PMID: 35100352.
      View in: PubMed
    11. Evers SS, Shao Y, Ramakrishnan SK, Shin JH, Bozadjieva-Kramer N, Irmler M, Stemmer K, Sandoval DA, Shah YM, Seeley RJ. Gut HIF2a signaling is increased after VSG, and gut activation of HIF2a decreases weight, improves glucose, and increases GLP-1 secretion. Cell Rep. 2022 01 18; 38(3):110270. PMID: 35045308.
      View in: PubMed
    12. Shao Y, Evers SS, Shin JH, Ramakrishnan SK, Bozadjieva-Kramer N, Yao Q, Shah YM, Sandoval DA, Seeley RJ. Vertical sleeve gastrectomy increases duodenal Lactobacillus spp. richness associated with the activation of intestinal HIF2a signaling and metabolic benefits. Mol Metab. 2022 03; 57:101432. PMID: 34998940.
      View in: PubMed
    13. Bethea M, Bozadjieva-Kramer N, Sandoval DA. Preproglucagon Products and Their Respective Roles Regulating Insulin Secretion. Endocrinology. 2021 10 01; 162(10). PMID: 34318874.
      View in: PubMed
    14. Bozadjieva-Kramer N, Shin JH, Shao Y, Gutierrez-Aguilar R, Li Z, Heppner KM, Chiang S, Vargo SG, Granger K, Sandoval DA, MacDougald OA, Seeley RJ. Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice. Nat Commun. 2021 08 06; 12(1):4768. PMID: 34362888.
      View in: PubMed
    15. Sandoval DA, Alonso LC, Gannon M, Sander M, Sussel L, Reusch JEB. Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent. Diabetes. 2021 08 01; 70(8):1634-1637. PMID: 35381060.
      View in: PubMed
    16. Sandoval DA, Alonso LC, Gannon M, Sander M, Sussel L, Reusch JEB. Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent. Diabetes Care. 2021 08; 44(8):1744-1747. PMID: 34131046.
      View in: PubMed
    17. Hutch CR, Stelmak D, Kanke M, Koch-Laskowski K, Cummings B, Griffin C, Leix K, Sethupathy P, Singer K, Sandoval DA. Diet-dependent sex differences in the response to vertical sleeve gastrectomy. Am J Physiol Endocrinol Metab. 2021 07 01; 321(1):E11-E23. PMID: 33998293.
      View in: PubMed
    18. de Lima JBM, Debarba LK, Rupp AC, Qi N, Ubah C, Khan M, Didyuk O, Ayyar I, Koch M, Sandoval DA, Sadagurski M. ARCGHR Neurons Regulate Muscle Glucose Uptake. Cells. 2021 05 03; 10(5). PMID: 34063647.
      View in: PubMed
    19. Sandoval D. Updating the Role of a-Cell Preproglucagon Products on GLP-1 Receptor-Mediated Insulin Secretion. Diabetes. 2020 11; 69(11):2238-2245. PMID: 33082272.
      View in: PubMed
    20. Bozadjieva Kramer N, Evers SS, Shin JH, Silverwood S, Wang Y, Burant CF, Sandoval DA, Seeley RJ. The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation. Cell Rep. 2020 10 13; 33(2):108239. PMID: 33053352.
      View in: PubMed
    21. Myronovych A, Bhattacharjee J, Salazar-Gonzalez RM, Tan B, Mowery S, Ferguson D, Ryan KK, Zhang W, Zhao X, Oehrle M, Setchell KD, Seeley RJ, Sandoval DA, Kohli R. Assessment of the role of FGF15 in mediating the metabolic outcomes of murine Vertical Sleeve Gastrectomy (VSG). Am J Physiol Gastrointest Liver Physiol. 2020 Sep 23. PMID: 32967428.
      View in: PubMed
    22. Singha A, Palavicini JP, Pan M, Farmer S, Sandoval D, Han X, Fujikawa T. Leptin Receptors in RIP-Cre25Mgn Neurons Mediate Anti-dyslipidemia Effects of Leptin in Insulin-Deficient Mice. Front Endocrinol (Lausanne). 2020; 11:588447. PMID: 33071988.
      View in: PubMed
    23. Flak JN, Goforth PB, Dell'Orco J, Sabatini PV, Li C, Bozadjieva N, Sorensen M, Valenta A, Rupp A, Affinati AH, Cras-M?neur C, Ansari A, Sacksner J, Kodur N, Sandoval DA, Kennedy RT, Olson DP, Myers MG. Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin. J Clin Invest. 2020 06 01; 130(6):2943-2952. PMID: 32134398.
      View in: PubMed
    24. Panaro BL, Yusta B, Matthews D, Koehler JA, Song Y, Sandoval DA, Drucker DJ. Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion. Mol Metab. 2020 07; 37:100990. PMID: 32278655.
      View in: PubMed
    25. Cheng W, Ndoka E, Hutch C, Roelofs K, MacKinnon A, Khoury B, Magrisso J, Kim KS, Rhodes CJ, Olson DP, Seeley RJ, Sandoval D, Myers MG. Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice. JCI Insight. 2020 04 09; 5(7). PMID: 32182221.
      View in: PubMed
    26. Davis EM, Sandoval DA. Glucagon-Like Peptide-1: Actions and Influence on Pancreatic Hormone Function. Compr Physiol. 2020 03 12; 10(2):577-595. PMID: 32163198.
      View in: PubMed
    27. Hutch CR, Trakimas DR, Roelofs K, Pressler J, Sorrell J, Cota D, Obici S, Sandoval DA. Oea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy. Ann Surg. 2020 03; 271(3):509-518. PMID: 30702457.
      View in: PubMed
    28. Cheng W, Gonzalez I, Pan W, Tsang AH, Adams J, Ndoka E, Gordian D, Khoury B, Roelofs K, Evers SS, MacKinnon A, Wu S, Frikke-Schmidt H, Flak JN, Trevaskis JL, Rhodes CJ, Fukada SI, Seeley RJ, Sandoval DA, Olson DP, Blouet C, Myers MG. Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding. Cell Metab. 2020 02 04; 31(2):301-312.e5. PMID: 31955990.
      View in: PubMed
    29. Evers SS, Kim KS, Bozadjieva N, Lewis AG, Farris D, Sorensen MJ, Kim Y, Whitesall SE, Kennedy RT, Michele DE, Seeley RJ, Sandoval DA. Continuous glucose monitoring reveals glycemic variability and hypoglycemia after vertical sleeve gastrectomy in rats. Mol Metab. 2020 02; 32:148-159. PMID: 32029224.
      View in: PubMed
    30. Framnes-DeBoer SN, Bakke E, Yalamanchili S, Peterson H, Sandoval DA, Seeley RJ, Arble DM. Bromocriptine improves glucose tolerance independent of circadian timing, prolactin, or the melanocortin-4 receptor. Am J Physiol Endocrinol Metab. 2020 01 01; 318(1):E62-E71. PMID: 31794265.
      View in: PubMed
    31. Alvarez R, Sandoval DA, Seeley RJ. A rodent model of partial intestinal diversion: a novel metabolic operation. Surg Obes Relat Dis. 2020 Feb; 16(2):270-281. PMID: 31874737.
      View in: PubMed
    32. Kim KS, Hutch CR, Wood L, Magrisso IJ, Seeley RJ, Sandoval DA. Glycemic effect of pancreatic preproglucagon in mouse sleeve gastrectomy. JCI Insight. 2019 10 17; 4(20). PMID: 31619587.
      View in: PubMed
    33. M?ller TD, Finan B, Bloom SR, D'Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tsch?p MH. Glucagon-like peptide 1 (GLP-1). Mol Metab. 2019 12; 30:72-130. PMID: 31767182.
      View in: PubMed
    34. Song Y, Koehler JA, Baggio LL, Powers AC, Sandoval DA, Drucker DJ. Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice. Cell Metab. 2019 11 05; 30(5):976-986.e3. PMID: 31495689.
      View in: PubMed
    35. Hutch CR, Roelofs K, Haller A, Sorrell J, Leix K, D'Alessio DD, Augustin R, Seeley RJ, Klein T, Sandoval DA. The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice. Diabetologia. 2019 10; 62(10):1928-1937. PMID: 31414143.
      View in: PubMed
    36. Khera E, Zhang L, Roberts S, Nessler I, Sandoval D, Reiner T, Thurber GM. Blocking of Glucagonlike Peptide-1 Receptors in the Exocrine Pancreas Improves Specificity for ?-Cells in a Mouse Model of Type 1 Diabetes. J Nucl Med. 2019 11; 60(11):1635-1641. PMID: 31076502.
      View in: PubMed
    37. Li Z, Hardij J, Evers SS, Hutch CR, Choi SM, Shao Y, Learman BS, Lewis KT, Schill RL, Mori H, Bagchi DP, Romanelli SM, Kim KS, Bowers E, Griffin C, Seeley RJ, Singer K, Sandoval DA, Rosen CJ, MacDougald OA. G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche. J Clin Invest. 2019 05 06; 129(6):2404-2416. PMID: 31063988.
      View in: PubMed
    38. Sandoval DA. Mechanisms for the metabolic success of bariatric surgery. J Neuroendocrinol. 2019 05; 31(5):e12708. PMID: 30882956.
      View in: PubMed
    39. Griffin C, Hutch CR, Abrishami S, Stelmak D, Eter L, Li Z, Chang E, Agarwal D, Zamarron B, Varghese M, Subbaiah P, MacDougald OA, Sandoval DA, Singer K. Inflammatory responses to dietary and surgical weight loss in male and female mice. Biol Sex Differ. 2019 04 03; 10(1):16. PMID: 30944030.
      View in: PubMed
    40. Arble DM, Schwartz AR, Polotsky VY, Sandoval DA, Seeley RJ. Vertical sleeve gastrectomy improves ventilatory drive through a leptin-dependent mechanism. JCI Insight. 2019 Jan 10; 4(1). PMID: 30626748.
      View in: PubMed
    41. Kim T, Holleman CL, Nason S, Arble DM, Ottaway N, Chabenne J, Loyd C, Kim JA, Sandoval D, Drucker DJ, DiMarchi R, Perez-Tilve D, Habegger KM. Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents. Diabetes. 2018 11; 67(11):2157-2166. PMID: 30150304.
      View in: PubMed
    42. Adams JM, Pei H, Sandoval DA, Seeley RJ, Chang RB, Liberles SD, Olson DP. Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor-Expressing Glutamatergic Neurons. Diabetes. 2018 08; 67(8):1538-1548. PMID: 29776968.
      View in: PubMed
    43. Wood L, Roelofs K, Koch LG, Britton SL, Sandoval DA. Vertical sleeve gastrectomy corrects metabolic perturbations in a low-exercise capacity rat model. Mol Metab. 2018 05; 11:189-196. PMID: 29519582.
      View in: PubMed
    44. Kim KS, Seeley RJ, Sandoval DA. Signalling from the periphery to the brain that regulates energy homeostasis. Nat Rev Neurosci. 2018 04; 19(4):185-196. PMID: 29467468.
      View in: PubMed
    45. Hutch CR, Sandoval D. The Role of GLP-1 in the Metabolic Success of Bariatric Surgery. Endocrinology. 2017 12 01; 158(12):4139-4151. PMID: 29040429.
      View in: PubMed
    46. Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, Garc?a-C?ceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabe de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, M?ller TD, DiMarchi RD, Finan B, Tsch?p MH. Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell Metab. 2017 Oct 03; 26(4):620-632.e6. PMID: 28943448.
      View in: PubMed
    47. Burmeister MA, Brown JD, Ayala JE, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE. The glucagon-like peptide-1 receptor in the ventromedial hypothalamus reduces short-term food intake in male mice by regulating nutrient sensor activity. Am J Physiol Endocrinol Metab. 2017 12 01; 313(6):E651-E662. PMID: 28811293.
      View in: PubMed
    48. Jessen L, Smith EP, Ulrich-Lai Y, Herman JP, Seeley RJ, Sandoval D, D'Alessio D. Central Nervous System GLP-1 Receptors Regulate Islet Hormone Secretion and Glucose Homeostasis in Male Rats. Endocrinology. 2017 07 01; 158(7):2124-2133. PMID: 28430981.
      View in: PubMed
    49. Kim KS, Sandoval DA. Endocrine Function after Bariatric Surgery. Compr Physiol. 2017 06 18; 7(3):783-798. PMID: 28640442.
      View in: PubMed
    50. Wismann P, Barkholt P, Secher T, Vrang N, Hansen HB, Jeppesen PB, Baggio LL, Koehler JA, Drucker DJ, Sandoval DA, Jelsing J. The endogenous preproglucagon system is not essential for gut growth homeostasis in mice. Mol Metab. 2017 07; 6(7):681-692. PMID: 28702324.
      View in: PubMed
    51. Chambers AP, Sorrell JE, Haller A, Roelofs K, Hutch CR, Kim KS, Gutierrez-Aguilar R, Li B, Drucker DJ, D'Alessio DA, Seeley RJ, Sandoval DA. The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice. Cell Metab. 2017 Apr 04; 25(4):927-934.e3. PMID: 28325479.
      View in: PubMed
    52. Cady G, Landeryou T, Garratt M, Kopchick JJ, Qi N, Garcia-Galiano D, Elias CF, Myers MG, Miller RA, Sandoval DA, Sadagurski M. Hypothalamic growth hormone receptor (GHR)?controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons. Mol Metab. 2017 05; 6(5):393-405. PMID: 28462074.
      View in: PubMed
    53. Frikke-Schmidt H, Zamarron BF, O'Rourke RW, Sandoval DA, Lumeng CN, Seeley RJ. Weight loss independent changes in adipose tissue macrophage and T cell populations after sleeve gastrectomy in mice. Mol Metab. 2017 04; 6(4):317-326. PMID: 28377871.
      View in: PubMed
    54. Sandoval DA, Seeley RJ. Physiology: Gut feeling for food choice. Nature. 2017 02 16; 542(7641):302-303. PMID: 28178229.
      View in: PubMed
    55. Grayson BE, Gutierrez-Aguilar R, Sorrell JE, Matter EK, Adams MR, Howles P, Karns R, Seeley RJ, Sandoval DA. Bariatric surgery emphasizes biological sex differences in rodent hepatic lipid handling. Biol Sex Differ. 2017; 8:4. PMID: 28149499.
      View in: PubMed
    56. Burmeister MA, Ayala JE, Smouse H, Landivar-Rocha A, Brown JD, Drucker DJ, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE. The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice. Diabetes. 2017 02; 66(2):372-384. PMID: 27908915.
      View in: PubMed
    57. Evers SS, Sandoval DA, Seeley RJ. The Physiology and Molecular Underpinnings of the Effects of Bariatric Surgery on Obesity and Diabetes. Annu Rev Physiol. 2017 02 10; 79:313-334. PMID: 27912678.
      View in: PubMed
    58. Hutch CR, Sandoval DA. Physiological and molecular responses to bariatric surgery: markers or mechanisms underlying T2DM resolution? Ann N Y Acad Sci. 2017 03; 1391(1):5-19. PMID: 27671525.
      View in: PubMed
    59. Kulkarni BV, LaSance K, Sorrell JE, Lemen L, Woods SC, Seeley RJ, Sandoval D. The role of proximal versus distal stomach resection in the weight loss seen after vertical sleeve gastrectomy. Am J Physiol Regul Integr Comp Physiol. 2016 11 01; 311(5):R979-R987. PMID: 27581811.
      View in: PubMed
    60. Loyd C, Magrisso IJ, Haas M, Balusu S, Krishna R, Itoh N, Sandoval DA, Perez-Tilve D, Obici S, Habegger KM. Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding. J Appl Physiol (1985). 2016 09 01; 121(3):687-98. PMID: 27445299.
      View in: PubMed
    61. Seeley RJ, Sandoval DA. Targeting the brain as a cure for type 2 diabetes. Nat Med. 2016 07 07; 22(7):709-11. PMID: 27387884.
      View in: PubMed
    62. Frikke-Schmidt H, O'Rourke RW, Lumeng CN, Sandoval DA, Seeley RJ. Does bariatric surgery improve adipose tissue function? Obes Rev. 2016 09; 17(9):795-809. PMID: 27272117.
      View in: PubMed
    63. Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA. Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Diabetes. 2016 09; 65(9):2732-41. PMID: 27217488.
      View in: PubMed
    64. Arble DM, Pressler JW, Sorrell J, Wevrick R, Sandoval DA. Sleeve gastrectomy leads to weight loss in the Magel2 knockout mouse. Surg Obes Relat Dis. 2016 Dec; 12(10):1795-1802. PMID: 27396546.
      View in: PubMed
    65. Sandoval D. Roux-en-Y Gastric Bypass and Vertical Sleeve Gastrectomy: Divergent Pathways to Improved Glucose Homeostasis. Gastroenterology. 2016 Feb; 150(2):309-12. PMID: 26710990.
      View in: PubMed
    66. Obici S, Magrisso IJ, Ghazarian AS, Shirazian A, Miller JR, Loyd CM, Begg DP, Krawczewski Carhuatanta KA, Haas MK, Davis JF, Woods SC, Sandoval DA, Seeley RJ, Goodyear LJ, Pothos EN, Mul JD. Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation. Mol Metab. 2015 Oct; 4(10):692-705. PMID: 26500841.
      View in: PubMed
    67. Kohli R, Myronovych A, Tan BK, Salazar-Gonzalez RM, Miles L, Zhang W, Oehrle M, Sandoval DA, Ryan KK, Seeley RJ, Setchell KD. Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH? Dig Dis. 2015; 33(3):440-6. PMID: 26045281.
      View in: PubMed
    68. Arble DM, Sandoval DA, Turek FW, Woods SC, Seeley RJ. Metabolic effects of bariatric surgery in mouse models of circadian disruption. Int J Obes (Lond). 2015 Aug; 39(8):1310-8. PMID: 25869599.
      View in: PubMed
    69. Sandoval DA, D'Alessio DA. Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease. Physiol Rev. 2015 Apr; 95(2):513-48. PMID: 25834231.
      View in: PubMed
    70. Arble DM, Holland J, Ottaway N, Sorrell J, Pressler JW, Morano R, Woods SC, Seeley RJ, Herman JP, Sandoval DA, Perez-Tilve D. The melanocortin-4 receptor integrates circadian light cues and metabolism. Endocrinology. 2015 May; 156(5):1685-91. PMID: 25730108.
      View in: PubMed
    71. Sandoval D, Sisley SR. Brain GLP-1 and insulin sensitivity. Mol Cell Endocrinol. 2015 Dec 15; 418 Pt 1:27-32. PMID: 25724479.
      View in: PubMed
    72. Seeley RJ, Chambers AP, Sandoval DA. The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes. Cell Metab. 2015 Mar 03; 21(3):369-78. PMID: 25662404.
      View in: PubMed
    73. Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, M?ller TD, Perez-Tilve D, DiMarchi RD, Tsch?p MH. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nat Med. 2015 Jan; 21(1):27-36. PMID: 25485909.
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    74. Arble DM, Sandoval DA, Seeley RJ. Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery. Diabetologia. 2015 Feb; 58(2):211-20. PMID: 25374275.
      View in: PubMed
    75. Mul JD, Begg DP, Haller AM, Pressler JW, Sorrell J, Woods SC, Farese RV, Seeley RJ, Sandoval DA. MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse. Am J Physiol Endocrinol Metab. 2014 Dec 01; 307(11):E1065-72. PMID: 25315695.
      View in: PubMed
    76. Pressler JW, Haller A, Sorrell J, Wang F, Seeley RJ, Tso P, Sandoval DA. Vertical sleeve gastrectomy restores glucose homeostasis in apolipoprotein A-IV KO mice. Diabetes. 2015 Feb; 64(2):498-507. PMID: 25157093.
      View in: PubMed
    77. Sisley S, Smith K, Sandoval DA, Seeley RJ. Differences in acute anorectic effects of long-acting GLP-1 receptor agonists in rats. Peptides. 2014 Aug; 58:1-6. PMID: 24879927.
      View in: PubMed
    78. Smith EP, An Z, Wagner C, Lewis AG, Cohen EB, Li B, Mahbod P, Sandoval D, Perez-Tilve D, Tamarina N, Philipson LH, Stoffers DA, Seeley RJ, D'Alessio DA. The role of ? cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs. Cell Metab. 2014 Jun 03; 19(6):1050-7. PMID: 24836562.
      View in: PubMed
    79. Sisley S, Gutierrez-Aguilar R, Scott M, D'Alessio DA, Sandoval DA, Seeley RJ. Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. J Clin Invest. 2014 Jun; 124(6):2456-63. PMID: 24762441.
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    80. Ryan KK, Tremaroli V, Clemmensen C, Kovatcheva-Datchary P, Myronovych A, Karns R, Wilson-P?rez HE, Sandoval DA, Kohli R, B?ckhed F, Seeley RJ. FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature. 2014 May 08; 509(7499):183-8. PMID: 24670636.
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    81. Sandoval D. Old dog, new trick: a direct role for leptin in regulating microbiota composition. Endocrinology. 2014 Mar; 155(3):653-5. PMID: 24564414.
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    82. Chambers AP, Smith EP, Begg DP, Grayson BE, Sisley S, Greer T, Sorrell J, Lemmen L, LaSance K, Woods SC, Seeley RJ, D'Alessio DA, Sandoval DA. Regulation of gastric emptying rate and its role in nutrient-induced GLP-1 secretion in rats after vertical sleeve gastrectomy. Am J Physiol Endocrinol Metab. 2014 Feb 15; 306(4):E424-32. PMID: 24368666.
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    83. Heppner KM, Piechowski CL, M?ller A, Ottaway N, Sisley S, Smiley DL, Habegger KM, Pfluger PT, Dimarchi R, Biebermann H, Tsch?p MH, Sandoval DA, Perez-Tilve D. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes. 2014 Jan; 63(1):122-31. PMID: 24062249.
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    84. Bielohuby M, Sisley S, Sandoval D, Herbach N, Zengin A, Fischereder M, Menhofer D, Stoehr BJ, Stemmer K, Wanke R, Tsch?p MH, Seeley RJ, Bidlingmaier M. Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. Am J Physiol Endocrinol Metab. 2013 Nov 01; 305(9):E1059-70. PMID: 23982154.
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    85. Li B, Matter EK, Hoppert HT, Grayson BE, Seeley RJ, Sandoval DA. Identification of optimal reference genes for RT-qPCR in the rat hypothalamus and intestine for the study of obesity. Int J Obes (Lond). 2014 Feb; 38(2):192-7. PMID: 23736358.
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    86. Sandoval D, Dunki-Jacobs A, Sorrell J, Seeley RJ, D'Alessio DD. Impact of intestinal electrical stimulation on nutrient-induced GLP-1 secretion in vivo. Neurogastroenterol Motil. 2013 Aug; 25(8):700-5. PMID: 23663526.
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    87. Chambers AP, Sandoval DA, Seeley RJ. Integration of satiety signals by the central nervous system. Curr Biol. 2013 May 06; 23(9):R379-88. PMID: 23660361.
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    88. Mul JD, Begg DP, Barrera JG, Li B, Matter EK, D'Alessio DA, Woods SC, Seeley RJ, Sandoval DA. High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats. Am J Physiol Regul Integr Comp Physiol. 2013 Jul 01; 305(1):R68-77. PMID: 23616105.
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    89. Arble DM, Sandoval DA. CNS control of glucose metabolism: response to environmental challenges. Front Neurosci. 2013; 7:20. PMID: 23550218.
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    90. Wilson-P?rez HE, Chambers AP, Ryan KK, Li B, Sandoval DA, Stoffers D, Drucker DJ, P?rez-Tilve D, Seeley RJ. Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. Diabetes. 2013 Jul; 62(7):2380-5. PMID: 23434938.
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    91. Sandoval D, Barrera JG, Stefater MA, Sisley S, Woods SC, D'Alessio DD, Seeley RJ. The anorectic effect of GLP-1 in rats is nutrient dependent. PLoS One. 2012; 7(12):e51870. PMID: 23284795.
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    92. Grayson BE, Seeley RJ, Sandoval DA. Wired on sugar: the role of the CNS in the regulation of glucose homeostasis. Nat Rev Neurosci. 2013 Jan; 14(1):24-37. PMID: 23232606.
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    93. Chambers AP, Kirchner H, Wilson-Perez HE, Willency JA, Hale JE, Gaylinn BD, Thorner MO, Pfluger PT, Gutierrez JA, Tsch?p MH, Sandoval DA, Seeley RJ. The effects of vertical sleeve gastrectomy in rodents are ghrelin independent. Gastroenterology. 2013 Jan; 144(1):50-52.e5. PMID: 22995675.
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    94. Chambers AP, Wilson-Perez HE, McGrath S, Grayson BE, Ryan KK, D'Alessio DA, Woods SC, Sandoval DA, Seeley RJ. Effect of vertical sleeve gastrectomy on food selection and satiation in rats. Am J Physiol Endocrinol Metab. 2012 Oct 15; 303(8):E1076-84. PMID: 22932782.
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    95. Kim DH, Sartor MA, Bain JR, Sandoval D, Stevens RD, Medvedovic M, Newgard CB, Woods SC, Seeley RJ. Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium. Diabetes. 2012 Sep; 61(9):2299-310. PMID: 22733798.
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    96. Stefater MA, Wilson-P?rez HE, Chambers AP, Sandoval DA, Seeley RJ. All bariatric surgeries are not created equal: insights from mechanistic comparisons. Endocr Rev. 2012 Aug; 33(4):595-622. PMID: 22550271.
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    97. Mul JD, Begg DP, Alsters SI, van Haaften G, Duran KJ, D'Alessio DA, le Roux CW, Woods SC, Sandoval DA, Blakemore AI, Cuppen E, van Haelst MM, Seeley RJ. Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats. Am J Physiol Endocrinol Metab. 2012 Jul 01; 303(1):E103-10. PMID: 22535749.
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    98. Wilson-P?rez HE, Chambers AP, Sandoval DA, Stefater MA, Woods SC, Benoit SC, Seeley RJ. The effect of vertical sleeve gastrectomy on food choice in rats. Int J Obes (Lond). 2013 Feb; 37(2):288-95. PMID: 22334194.
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    99. Sandoval DA, Ryan KK, de Kloet AD, Woods SC, Seeley RJ. Female rats are relatively more sensitive to reduced lipid versus reduced carbohydrate availability. Nutr Diabetes. 2012 Feb 13; 2:e27. PMID: 23169552.
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    100. Sisley S, Sandoval D. Hypothalamic control of energy and glucose metabolism. Rev Endocr Metab Disord. 2011 Sep; 12(3):219-33. PMID: 21695389.
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    101. Sandoval D. Bariatric surgeries: beyond restriction and malabsorption. Int J Obes (Lond). 2011 Sep; 35 Suppl 3:S45-9. PMID: 21912388.
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    102. Tong J, Sandoval DA. Is the GLP-1 system a viable therapeutic target for weight reduction? Rev Endocr Metab Disord. 2011 Sep; 12(3):187-95. PMID: 21336840.
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    103. Seeley RJ, Sandoval DA. Neuroscience: weight loss through smoking. Nature. 2011 Jul 13; 475(7355):176-7. PMID: 21753841.
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    104. Chambers AP, Jessen L, Ryan KK, Sisley S, Wilson-P?rez HE, Stefater MA, Gaitonde SG, Sorrell JE, Toure M, Berger J, D'Alessio DA, Woods SC, Seeley RJ, Sandoval DA. Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats. Gastroenterology. 2011 Sep; 141(3):950-8. PMID: 21699789.
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    105. Chambers AP, Stefater MA, Wilson-Perez HE, Jessen L, Sisley S, Ryan KK, Gaitonde S, Sorrell JE, Toure M, Berger J, D'Alessio DA, Sandoval DA, Seeley RJ, Woods SC. Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats. Physiol Behav. 2011 Nov 30; 105(1):120-3. PMID: 21683726.
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    106. Barrera JG, Sandoval DA, D'Alessio DA, Seeley RJ. GLP-1 and energy balance: an integrated model of short-term and long-term control. Nat Rev Endocrinol. 2011 Jun 07; 7(9):507-16. PMID: 21647189.
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    107. Stefater MA, Sandoval DA, Chambers AP, Wilson-P?rez HE, Hofmann SM, Jandacek R, Tso P, Woods SC, Seeley RJ. Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion. Gastroenterology. 2011 Sep; 141(3):939-949.e1-4. PMID: 21699773.
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    108. Sandoval DA, Seeley RJ. Medicine. The microbes made me eat it. Science. 2010 Apr 09; 328(5975):179-80. PMID: 20378804.
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    109. Stefater MA, P?rez-Tilve D, Chambers AP, Wilson-P?rez HE, Sandoval DA, Berger J, Toure M, Tsch?p M, Woods SC, Seeley RJ. Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. Gastroenterology. 2010 Jun; 138(7):2426-36, 2436.e1-3. PMID: 20226189.
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    110. Sandoval DA, Obici S, Seeley RJ. Targeting the CNS to treat type 2 diabetes. Nat Rev Drug Discov. 2009 May; 8(5):386-98. PMID: 19404312.
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    111. Cota D, Sandoval DA, Olivieri M, Prodi E, D'Alessio DA, Woods SC, Seeley RJ, Obici S. Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. Obesity (Silver Spring). 2009 Aug; 17(8):1641-5. PMID: 19325539.
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    112. Kim DH, Sandoval D, Reed JA, Matter EK, Tolod EG, Woods SC, Seeley RJ. The role of GM-CSF in adipose tissue inflammation. Am J Physiol Endocrinol Metab. 2008 Nov; 295(5):E1038-46. PMID: 18765677.
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    113. Sandoval D. CNS GLP-1 regulation of peripheral glucose homeostasis. Physiol Behav. 2008 Aug 06; 94(5):670-4. PMID: 18508100.
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    114. Sandoval DA, Bagnol D, Woods SC, D'Alessio DA, Seeley RJ. Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. Diabetes. 2008 Aug; 57(8):2046-54. PMID: 18487451.
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    115. Gustavson SM, Sandoval DA, Ertl AC, Bao S, Raj SR, Davis SN. Stimulation of both type I and type II corticosteroid receptors blunts counterregulatory responses to subsequent hypoglycemia in healthy man. Am J Physiol Endocrinol Metab. 2008 Mar; 294(3):E506-12. PMID: 18182467.
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    116. Sandoval D, Cota D, Seeley RJ. The integrative role of CNS fuel-sensing mechanisms in energy balance and glucose regulation. Annu Rev Physiol. 2008; 70:513-35. PMID: 17988209.
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    117. Sandoval DA, Gong B, Davis SN. Forebrain and hindbrain effects of ethanol on counterregulatory responses to hypoglycemia in conscious rats. Metabolism. 2007 Dec; 56(12):1623-8. PMID: 17998012.
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    118. Sandoval DA, Gong B, Davis SN. Antecedent short-term central nervous system administration of estrogen and progesterone alters counterregulatory responses to hypoglycemia in conscious male rats. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1511-6. PMID: 17940215.
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    119. Sandoval DA, Davis SN. Metabolic consequences of exercise-associated autonomic failure. Exerc Sport Sci Rev. 2006 Apr; 34(2):72-6. PMID: 16672804.
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    120. Sandoval DA, Guy DL, Richardson MA, Ertl AC, Davis SN. Acute, same-day effects of antecedent exercise on counterregulatory responses to subsequent hypoglycemia in type 1 diabetes mellitus. Am J Physiol Endocrinol Metab. 2006 Jun; 290(6):E1331-8. PMID: 16449302.
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    121. D'Alessio DA, Sandoval DA, Seeley RJ. New ways in which GLP-1 can regulate glucose homeostasis. J Clin Invest. 2005 Dec; 115(12):3406-8. PMID: 16322789.
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    122. Aftab Guy D, Sandoval D, Richardson MA, Tate D, Davis SN. Effects of glycemic control on target organ responses to epinephrine in type 1 diabetes. Am J Physiol Endocrinol Metab. 2005 Aug; 289(2):E258-65. PMID: 15784645.
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    123. Guy DA, Sandoval D, Richardson MA, Tate D, Flakoll PJ, Davis SN. Differing physiological effects of epinephrine in type 1 diabetes and nondiabetic humans. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E178-86. PMID: 15585598.
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    124. Sandoval DA, Ping L, Neill RA, Gong B, Walsh K, Davis SN. Brain region-dependent effects of dexamethasone on counterregulatory responses to hypoglycemia in conscious rats. Am J Physiol Regul Integr Comp Physiol. 2005 Feb; 288(2):R413-9. PMID: 15486094.
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    125. Sandoval DA, Guy DL, Richardson MA, Ertl AC, Davis SN. Effects of low and moderate antecedent exercise on counterregulatory responses to subsequent hypoglycemia in type 1 diabetes. Diabetes. 2004 Jul; 53(7):1798-806. PMID: 15220204.
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    126. Sandoval DA, Ping L, Neill RA, Morrey S, Davis SN. The effects of dehydroepiandrosterone sulfate on counterregulatory responses during repeated hypoglycemia in conscious normal rats. Diabetes. 2004 Mar; 53(3):679-86. PMID: 14988252.
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    127. Sandoval DA, Galassetti P, Tate D, Neill A, Davis SN. Leptin responses to antecedent exercise and hypoglycemia in healthy and type 1 diabetes mellitus men and women. J Diabetes Complications. 2003 Nov-Dec; 17(6):301-6. PMID: 14583173.
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    128. Sandoval DA, Ping L, Neill AR, Morrey S, Davis SN. Cortisol acts through central mechanisms to blunt counterregulatory responses to hypoglycemia in conscious rats. Diabetes. 2003 Sep; 52(9):2198-204. PMID: 12941757.
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    129. Sandoval DA, Ertl AC, Richardson MA, Tate DB, Davis SN. Estrogen blunts neuroendocrine and metabolic responses to hypoglycemia. Diabetes. 2003 Jul; 52(7):1749-55. PMID: 12829642.
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    130. Sandoval DA, Davis SN. Leptin: metabolic control and regulation. J Diabetes Complications. 2003 Mar-Apr; 17(2):108-13. PMID: 12614978.
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    131. Sandoval DA, Matt KS. Effects of the oral contraceptive pill cycle on physiological responses to hypoxic exercise. High Alt Med Biol. 2003; 4(1):61-72. PMID: 12713713.
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    132. Sandoval DA, Matt KS. Gender differences in the endocrine and metabolic responses to hypoxic exercise. J Appl Physiol (1985). 2002 Feb; 92(2):504-12. PMID: 11796657.
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    133. Roach RC, Maes D, Sandoval D, Robergs RA, Icenogle M, Hinghofer-Szalkay H, Lium D, Loeppky JA. Exercise exacerbates acute mountain sickness at simulated high altitude. J Appl Physiol (1985). 2000 Feb; 88(2):581-5. PMID: 10658026.
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    134. Gukovskaya AS, Gukovsky I, Zaninovic V, Song M, Sandoval D, Gukovsky S, Pandol SJ. Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis. J Clin Invest. 1997 Oct 01; 100(7):1853-62. PMID: 9312187.
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    135. Li X, Sandoval D, Freeberg L, Carter RH. Role of CD19 tyrosine 391 in synergistic activation of B lymphocytes by coligation of CD19 and membrane Ig. J Immunol. 1997 Jun 15; 158(12):5649-57. PMID: 9190913.
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    136. Sandoval D, Gukovskaya A, Reavey P, Gukovsky S, Sisk A, Braquet P, Pandol SJ, Poucell-Hatton S. The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. Gastroenterology. 1996 Oct; 111(4):1081-91. PMID: 8831604.
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    137. Gukovskaya AS, Perkins P, Zaninovic V, Sandoval D, Rutherford R, Fitzsimmons T, Pandol SJ, Poucell-Hatton S. Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat. Gastroenterology. 1996 Mar; 110(3):875-84. PMID: 8608898.
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