 Glucagon-Secreting Cells
"Glucagon-Secreting Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A type of pancreatic cell representing about 5-20% of the islet cells. Alpha cells secrete GLUCAGON.
| Descriptor ID |
D050416
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| MeSH Number(s) |
A03.734.414.065 A06.390.087 A06.407.414.043 A11.382.625.064 A11.436.294.064
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| Concept/Terms |
Glucagon-Secreting Cells- Glucagon-Secreting Cells
- Cell, Glucagon-Secreting
- Cells, Glucagon-Secreting
- Glucagon Secreting Cells
- Glucagon-Secreting Cell
- Pancreatic A Cells
- Pancreatic A Cell
- alpha Cells, Pancreatic
- Pancreatic alpha Cell
- alpha Cell, Pancreatic
- Pancreatic alpha Cells
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Below are MeSH descriptors whose meaning is more general than "Glucagon-Secreting Cells".
Below are MeSH descriptors whose meaning is more specific than "Glucagon-Secreting Cells".
This graph shows the total number of publications written about "Glucagon-Secreting Cells" by people in this website by year, and whether "Glucagon-Secreting Cells" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 2 | 0 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 1 | 2 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 4 | 0 | 4 | | 2021 | 1 | 0 | 1 | | 2023 | 2 | 0 | 2 | | 2024 | 1 | 0 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Glucagon-Secreting Cells" by people in Profiles.
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Brooks EP, Casey MR, Wells KL, Liu TY, Van Orman M, Sussel L. NKX2.2 and KLF4 cooperate to regulate a-cell identity. Genes Dev. 2025 Feb 03; 39(3-4):242-260.
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Cilvik SN, Boehmer B, Wesolowski SR, Brown LD, Rozance PJ. Chronic late gestation fetal hyperglucagonaemia results in lower insulin secretion, pancreatic mass, islet area and beta- and a-cell proliferation. J Physiol. 2024 Nov; 602(22):6329-6345.
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Brooks EP, Sussel L. Not the second fiddle: a cell development, identity, and function in health and diabetes. J Endocrinol. 2023 08 01; 258(2).
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Arble DM, Hutch CR, Hafner H, Stelmak D, Leix K, Sorrell J, Pressler JW, Gregg B, Sandoval DA. The role of preproglucagon peptides in regulating ?-cell morphology and responses to streptozotocin-induced diabetes. Am J Physiol Endocrinol Metab. 2023 03 01; 324(3):E217-E225.
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Bethea M, Bozadjieva-Kramer N, Sandoval DA. Preproglucagon Products and Their Respective Roles Regulating Insulin Secretion. Endocrinology. 2021 10 01; 162(10).
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Sandoval D. Updating the Role of a-Cell Preproglucagon Products on GLP-1 Receptor-Mediated Insulin Secretion. Diabetes. 2020 11; 69(11):2238-2245.
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Ghazvini Zadeh EH, Huang Z, Xia J, Li D, Davidson HW, Li WH. ZIGIR, a Granule-Specific Zn2+ Indicator, Reveals Human Islet a Cell Heterogeneity. Cell Rep. 2020 07 14; 32(2):107904.
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Russell R, Carnese PP, Hennings TG, Walker EM, Russ HA, Liu JS, Giacometti S, Stein R, Hebrok M. Loss of the transcription factor MAFB limits ?-cell derivation from human PSCs. Nat Commun. 2020 06 02; 11(1):2742.
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Rickels MR, Evans-Molina C, Bahnson HT, Ylescupidez A, Nadeau KJ, Hao W, Clements MA, Sherr JL, Pratley RE, Hannon TS, Shah VN, Miller KM, Greenbaum CJ. High residual C-peptide likely contributes to glycemic control in type 1 diabetes. J Clin Invest. 2020 04 01; 130(4):1850-1862.
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Davis EM, Sandoval DA. Glucagon-Like Peptide-1: Actions and Influence on Pancreatic Hormone Function. Compr Physiol. 2020 03 12; 10(2):577-595.
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