 Glucagon-Secreting Cells
"Glucagon-Secreting Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A type of pancreatic cell representing about 5-20% of the islet cells. Alpha cells secrete GLUCAGON.
| Descriptor ID |
D050416
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| MeSH Number(s) |
A03.734.414.065 A06.390.087 A06.407.414.043 A11.382.625.064 A11.436.294.064
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| Concept/Terms |
Glucagon-Secreting Cells- Glucagon-Secreting Cells
- Cell, Glucagon-Secreting
- Cells, Glucagon-Secreting
- Glucagon Secreting Cells
- Glucagon-Secreting Cell
- Pancreatic A Cells
- Pancreatic A Cell
- alpha Cells, Pancreatic
- Pancreatic alpha Cell
- alpha Cell, Pancreatic
- Pancreatic alpha Cells
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Below are MeSH descriptors whose meaning is more general than "Glucagon-Secreting Cells".
Below are MeSH descriptors whose meaning is more specific than "Glucagon-Secreting Cells".
This graph shows the total number of publications written about "Glucagon-Secreting Cells" by people in this website by year, and whether "Glucagon-Secreting Cells" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 2 | 0 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 1 | 2 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2020 | 4 | 0 | 4 | | 2021 | 1 | 0 | 1 | | 2023 | 2 | 0 | 2 | | 2024 | 1 | 0 | 1 | | 2025 | 1 | 0 | 1 | | 2026 | 1 | 2 | 3 |
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Below are the most recent publications written about "Glucagon-Secreting Cells" by people in Profiles.
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Hansen MS, Hill CJ, Sussel L, Wells KL. Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets. Diabetes. 2026 Apr 01; 75(4):606-616.
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Zhu W, Pan L, Cui X, Russo AC, Ray R, Pederson B, Wei X, Lin LL, Torres M, Hafner H, Gregg B, Shrestha N, Liu C, Naji A, Arvan P, Sandoval DA, Lindberg I, Qi L, Reinert RB. SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet a cells. Nat Commun. 2026 Feb 25; 17(1).
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Kahn SE, Tripputi M, Lachin JM, Balasubramanyam A, Banerji MA, Barzilay J, Cohen RM, Garvey WT, Gramzinski MR, Rasouli N, Rhee M, Seegmiller JC, Singh V, Sivitz WI, Steffes MW, Utzschneider K, DeFronzo RA. Differential Longitudinal Effects of Glucose-Lowering Medications on Glucagon and C-peptide Responses in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). Diabetes Care. 2026 Feb 01; 49(2):325-334.
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Brooks EP, Casey MR, Wells KL, Liu TY, Van Orman M, Sussel L. NKX2.2 and KLF4 cooperate to regulate a-cell identity. Genes Dev. 2025 02 03; 39(3-4):242-260.
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Cilvik SN, Boehmer B, Wesolowski SR, Brown LD, Rozance PJ. Chronic late gestation fetal hyperglucagonaemia results in lower insulin secretion, pancreatic mass, islet area and beta- and a-cell proliferation. J Physiol. 2024 11; 602(22):6329-6345.
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Brooks EP, Sussel L. Not the second fiddle: a cell development, identity, and function in health and diabetes. J Endocrinol. 2023 08 01; 258(2).
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Arble DM, Hutch CR, Hafner H, Stelmak D, Leix K, Sorrell J, Pressler JW, Gregg B, Sandoval DA. The role of preproglucagon peptides in regulating ß-cell morphology and responses to streptozotocin-induced diabetes. Am J Physiol Endocrinol Metab. 2023 03 01; 324(3):E217-E225.
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Bethea M, Bozadjieva-Kramer N, Sandoval DA. Preproglucagon Products and Their Respective Roles Regulating Insulin Secretion. Endocrinology. 2021 10 01; 162(10).
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Sandoval D. Updating the Role of a-Cell Preproglucagon Products on GLP-1 Receptor-Mediated Insulin Secretion. Diabetes. 2020 11; 69(11):2238-2245.
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Ghazvini Zadeh EH, Huang Z, Xia J, Li D, Davidson HW, Li WH. ZIGIR, a Granule-Specific Zn2+ Indicator, Reveals Human Islet a Cell Heterogeneity. Cell Rep. 2020 07 14; 32(2):107904.
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